Mutation of the TP53 gene and allelic imbalance at chromosome 17p13 in ductal carcinoma in situ.

2.50
Hdl Handle:
http://hdl.handle.net/10541/95827
Title:
Mutation of the TP53 gene and allelic imbalance at chromosome 17p13 in ductal carcinoma in situ.
Authors:
Munn, K E; Walker, R A; Menasce, Lia P; Varley, Jennifer
Abstract:
A panel of 36 cases of preinvasive breast lesions, including 35 cases of ductal carcinoma in situ (DCIS), has been examined for mutation of TP53, allelic imbalance (AI) on 17p13, and expression of TP53, in a number of cases, has been studied using immunohistochemistry. Areas of DCIS, with or without adjacent invasive or benign cells, have been separately microdissected from paraffin-embedded sections and analysed by PCR for genetic changes to chromosome 17p13. TP53 mutations and AI on 17p have been identified in cases of 'pure' DCIS as well as those with associated invasive carcinoma and, furthermore, have been identified in well-differentiated lesions as well as poorly differentiated ones.
Affiliation:
CRC Department of Cancer Genetics, Paterson Institute for Cancer Research, Christie Hospital, Manchester, UK.
Citation:
Mutation of the TP53 gene and allelic imbalance at chromosome 17p13 in ductal carcinoma in situ. 1996, 74 (10):1578-85 Br. J. Cancer
Journal:
British Journal of Cancer
Issue Date:
Nov-1996
URI:
http://hdl.handle.net/10541/95827
PubMed ID:
8932338
Type:
Article
Language:
en
ISSN:
0007-0920
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorMunn, K Een
dc.contributor.authorWalker, R Aen
dc.contributor.authorMenasce, Lia Pen
dc.contributor.authorVarley, Jenniferen
dc.date.accessioned2010-04-07T10:43:23Z-
dc.date.available2010-04-07T10:43:23Z-
dc.date.issued1996-11-
dc.identifier.citationMutation of the TP53 gene and allelic imbalance at chromosome 17p13 in ductal carcinoma in situ. 1996, 74 (10):1578-85 Br. J. Canceren
dc.identifier.issn0007-0920-
dc.identifier.pmid8932338-
dc.identifier.urihttp://hdl.handle.net/10541/95827-
dc.description.abstractA panel of 36 cases of preinvasive breast lesions, including 35 cases of ductal carcinoma in situ (DCIS), has been examined for mutation of TP53, allelic imbalance (AI) on 17p13, and expression of TP53, in a number of cases, has been studied using immunohistochemistry. Areas of DCIS, with or without adjacent invasive or benign cells, have been separately microdissected from paraffin-embedded sections and analysed by PCR for genetic changes to chromosome 17p13. TP53 mutations and AI on 17p have been identified in cases of 'pure' DCIS as well as those with associated invasive carcinoma and, furthermore, have been identified in well-differentiated lesions as well as poorly differentiated ones.en
dc.language.isoenen
dc.subjectBreast Canceren
dc.subjectCancer Stagingen
dc.subject.meshAlleles-
dc.subject.meshBreast Neoplasms-
dc.subject.meshCarcinoma in Situ-
dc.subject.meshCarcinoma, Ductal, Breast-
dc.subject.meshChromosomes, Human, Pair 17-
dc.subject.meshDisease Progression-
dc.subject.meshFemale-
dc.subject.meshGene Expression-
dc.subject.meshGenes, p53-
dc.subject.meshHumans-
dc.subject.meshImmunohistochemistry-
dc.subject.meshMutation-
dc.subject.meshNeoplasm Staging-
dc.titleMutation of the TP53 gene and allelic imbalance at chromosome 17p13 in ductal carcinoma in situ.en
dc.typeArticleen
dc.contributor.departmentCRC Department of Cancer Genetics, Paterson Institute for Cancer Research, Christie Hospital, Manchester, UK.en
dc.identifier.journalBritish Journal of Canceren

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