Expression of the vascular endothelial growth factor receptor, KDR, in human placenta.

2.50
Hdl Handle:
http://hdl.handle.net/10541/95820
Title:
Expression of the vascular endothelial growth factor receptor, KDR, in human placenta.
Authors:
Vuckovic, M; Ponting, J; Terman, B I; Niketic, V; Seif, M W; Kumar, Shant
Abstract:
Vascular endothelial growth factor (VEGF) is a heparin-binding growth factor known to act directly on vascular endothelial cells by promoting cell proliferation and permeability. To date, 3 structurally related cell surface receptors for VEGF, Flt-1, Flt-4 and KDR, have been identified and shown to be human type III receptor tyrosine kinases. The establishment of a vascular network is crucial to the development of the placenta and occurs through both angiogenesis and vasculogenesis. The signals controlling these processes are unclear. Immunohistochemical and in situ hybridisation techniques have localised VEGF in the trophoblast layers and VEGF binding to placental vascular endothelial cells and haemangioblasts has been shown, suggesting a role for VEGF and its receptors in development of the vascular network. In this study we have used specific antibodies to localise KDR and endothelial cells in 1st and 3rd trimester human placenta. The staining showed a colocalisation of KDR with endothelial cells and haemangioblasts. No staining of trophoblast cells was observed, but strong staining of the endothelial cells was seen in the villous stroma adjacent to areas of trophoblast proliferation.
Affiliation:
Institute of Endocrinology, Immunology and Nutrition, Faculty of Science, University of Belgrade, Yugoslavia.
Citation:
Expression of the vascular endothelial growth factor receptor, KDR, in human placenta. 1996, 188 ( Pt 2):361-6 J. Anat.
Journal:
Journal of Anatomy
Issue Date:
Apr-1996
URI:
http://hdl.handle.net/10541/95820
PubMed ID:
8621335
Type:
Article
Language:
en
ISSN:
0021-8782
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorVuckovic, Men
dc.contributor.authorPonting, Jen
dc.contributor.authorTerman, B Ien
dc.contributor.authorNiketic, Ven
dc.contributor.authorSeif, M Wen
dc.contributor.authorKumar, Shanten
dc.date.accessioned2010-04-07T08:51:16Z-
dc.date.available2010-04-07T08:51:16Z-
dc.date.issued1996-04-
dc.identifier.citationExpression of the vascular endothelial growth factor receptor, KDR, in human placenta. 1996, 188 ( Pt 2):361-6 J. Anat.en
dc.identifier.issn0021-8782-
dc.identifier.pmid8621335-
dc.identifier.urihttp://hdl.handle.net/10541/95820-
dc.description.abstractVascular endothelial growth factor (VEGF) is a heparin-binding growth factor known to act directly on vascular endothelial cells by promoting cell proliferation and permeability. To date, 3 structurally related cell surface receptors for VEGF, Flt-1, Flt-4 and KDR, have been identified and shown to be human type III receptor tyrosine kinases. The establishment of a vascular network is crucial to the development of the placenta and occurs through both angiogenesis and vasculogenesis. The signals controlling these processes are unclear. Immunohistochemical and in situ hybridisation techniques have localised VEGF in the trophoblast layers and VEGF binding to placental vascular endothelial cells and haemangioblasts has been shown, suggesting a role for VEGF and its receptors in development of the vascular network. In this study we have used specific antibodies to localise KDR and endothelial cells in 1st and 3rd trimester human placenta. The staining showed a colocalisation of KDR with endothelial cells and haemangioblasts. No staining of trophoblast cells was observed, but strong staining of the endothelial cells was seen in the villous stroma adjacent to areas of trophoblast proliferation.en
dc.language.isoenen
dc.subject.meshAntigens, CD31-
dc.subject.meshAntigens, Differentiation, Myelomonocytic-
dc.subject.meshCell Adhesion Molecules-
dc.subject.meshEndothelium, Vascular-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshImmunohistochemistry-
dc.subject.meshPlacenta-
dc.subject.meshPregnancy-
dc.subject.meshPregnancy Trimester, First-
dc.subject.meshPregnancy Trimester, Third-
dc.subject.meshReceptor Protein-Tyrosine Kinases-
dc.subject.meshReceptors, Growth Factor-
dc.subject.meshReceptors, Mitogen-
dc.subject.meshReceptors, Vascular Endothelial Growth Factor-
dc.titleExpression of the vascular endothelial growth factor receptor, KDR, in human placenta.en
dc.typeArticleen
dc.contributor.departmentInstitute of Endocrinology, Immunology and Nutrition, Faculty of Science, University of Belgrade, Yugoslavia.en
dc.identifier.journalJournal of Anatomyen
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