Exposure to extremely low frequency magnetic fields has no effect on growth rate or clonogenic potential of multipotential haemopoietic progenitor cells.

2.50
Hdl Handle:
http://hdl.handle.net/10541/95809
Title:
Exposure to extremely low frequency magnetic fields has no effect on growth rate or clonogenic potential of multipotential haemopoietic progenitor cells.
Authors:
Reipert, Brigit M; Allan, Donald; Dexter, T Michael
Abstract:
Recent reports indicate an increased risk of acute myeloid leukaemia in children exposed to extremely low frequency magnetic fields (ELFMFs) emitted by high voltage power lines, suggesting that ELFMFs may act as weak tumour promoters. We have investigated possible interactions of weak ELFMFs with primitive haemopoietic cells in vitro using the multipotential progenitor cell line FDCP-mix(A4). We have determined the proliferative activity and clonogenic potential of cells under both optimal and sub-optimal growth conditions and exposed to either ambient laboratory ELFMFs or three other ELFMF regimes representative of those produced by high voltage power lines: nulled fields, Ca2+-ion cyclotron resonance conditions at 50 Hz, and vertical 50 Hz fields of 6 muT(RMS). Using exposures of 1, 4, 7 and 21 days, we found no significant alteration of growth rate, cell-cycle state or clonogenic efficiency indicating that neither the proliferation nor self-renewal of multipotential FDCP-mix(A4) cells was perturbed.
Affiliation:
Cancer Research Campaign Department of Physics & Instrumentation, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, UK.
Citation:
Exposure to extremely low frequency magnetic fields has no effect on growth rate or clonogenic potential of multipotential haemopoietic progenitor cells. 1996, 13 (3-4):205-17 Growth Factors
Journal:
Growth Factors
Issue Date:
1996
URI:
http://hdl.handle.net/10541/95809
DOI:
10.3109/08977199609003222
PubMed ID:
8919028
Type:
Article
Language:
en
ISSN:
0897-7194
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorReipert, Brigit Men
dc.contributor.authorAllan, Donalden
dc.contributor.authorDexter, T Michaelen
dc.date.accessioned2010-04-07T08:50:21Z-
dc.date.available2010-04-07T08:50:21Z-
dc.date.issued1996-
dc.identifier.citationExposure to extremely low frequency magnetic fields has no effect on growth rate or clonogenic potential of multipotential haemopoietic progenitor cells. 1996, 13 (3-4):205-17 Growth Factorsen
dc.identifier.issn0897-7194-
dc.identifier.pmid8919028-
dc.identifier.doi10.3109/08977199609003222-
dc.identifier.urihttp://hdl.handle.net/10541/95809-
dc.description.abstractRecent reports indicate an increased risk of acute myeloid leukaemia in children exposed to extremely low frequency magnetic fields (ELFMFs) emitted by high voltage power lines, suggesting that ELFMFs may act as weak tumour promoters. We have investigated possible interactions of weak ELFMFs with primitive haemopoietic cells in vitro using the multipotential progenitor cell line FDCP-mix(A4). We have determined the proliferative activity and clonogenic potential of cells under both optimal and sub-optimal growth conditions and exposed to either ambient laboratory ELFMFs or three other ELFMF regimes representative of those produced by high voltage power lines: nulled fields, Ca2+-ion cyclotron resonance conditions at 50 Hz, and vertical 50 Hz fields of 6 muT(RMS). Using exposures of 1, 4, 7 and 21 days, we found no significant alteration of growth rate, cell-cycle state or clonogenic efficiency indicating that neither the proliferation nor self-renewal of multipotential FDCP-mix(A4) cells was perturbed.en
dc.language.isoenen
dc.subjectHaematopoietic Stem Cellsen
dc.subjectMyeloid Leukaemiaen
dc.subject.meshAcute Disease-
dc.subject.meshAnimals-
dc.subject.meshCell Division-
dc.subject.meshCell Line-
dc.subject.meshClone Cells-
dc.subject.meshFlow Cytometry-
dc.subject.meshHematopoietic Stem Cells-
dc.subject.meshLeukemia, Myeloid-
dc.subject.meshMagnetics-
dc.subject.meshMethionine-
dc.subject.meshMice-
dc.subject.meshRNA-
dc.subject.meshUridine-
dc.titleExposure to extremely low frequency magnetic fields has no effect on growth rate or clonogenic potential of multipotential haemopoietic progenitor cells.en
dc.typeArticleen
dc.contributor.departmentCancer Research Campaign Department of Physics & Instrumentation, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, UK.en
dc.identifier.journalGrowth Factorsen

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