Comparison of photodynamic therapy with cryotherapy in the treatment of Bowen's disease.

2.50
Hdl Handle:
http://hdl.handle.net/10541/95799
Title:
Comparison of photodynamic therapy with cryotherapy in the treatment of Bowen's disease.
Authors:
Morton, Colin A; Whitehurst, C; Moseley, H; McColl, J H; Moore, James V; Mackie, R M
Abstract:
The efficacy and suitability of photodynamic therapy (PDT) was compared with that of cryotherapy in the treatment of 40 lesions of Bowen's disease. Lesions were randomized to receive either cryotherapy with liquid nitrogen, or PDT using a portable desktop lamp incorporating a 300 W xenon short arc discharge source. A porphyrin precursor, 5-aminolaevulinic acid (5-ALA), was applied topically 4 h before irradiation in the PDT group. Each lesion received 125 J/cm2 at a fluence rate of 70 mW/cm2. All patients were reviewed at 2-monthly intervals and treatments repeated if required. Cryotherapy produced clearance in 10 of 20 lesions after one treatment, the remaining 10 lesions requiring two or three treatment applications. PDT resulted in clearance of 15 of 20 lesions after one treatment and of the remaining five lesions after a second treatment. The probability that a lesion cleared after one treatment was greater with PDT than cryotherapy (P < 0.01). Cryotherapy was associated with ulceration (five of 20), infection (two of 20) and recurrent disease (two of 20); no such complications occurred following PDT. PDT using a non-laser light source and topical 5-ALA appears to be at least as effective as cryotherapy in the treatment of Bowen's disease with fewer adverse effects.
Affiliation:
University Department of Dermatology, Western Infirmary, Glasgow, U.K.
Citation:
Comparison of photodynamic therapy with cryotherapy in the treatment of Bowen's disease. 1996, 135 (5):766-71 Br. J. Dermatol.
Journal:
The British Journal of Dermatology
Issue Date:
Nov-1996
URI:
http://hdl.handle.net/10541/95799
DOI:
10.1046/j.1365-2133.1996.d01-1076.x
PubMed ID:
8977678
Type:
Article
Language:
en
ISSN:
0007-0963
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorMorton, Colin Aen
dc.contributor.authorWhitehurst, Cen
dc.contributor.authorMoseley, Hen
dc.contributor.authorMcColl, J Hen
dc.contributor.authorMoore, James Ven
dc.contributor.authorMackie, R Men
dc.date.accessioned2010-04-07T08:20:56Z-
dc.date.available2010-04-07T08:20:56Z-
dc.date.issued1996-11-
dc.identifier.citationComparison of photodynamic therapy with cryotherapy in the treatment of Bowen's disease. 1996, 135 (5):766-71 Br. J. Dermatol.en
dc.identifier.issn0007-0963-
dc.identifier.pmid8977678-
dc.identifier.doi10.1046/j.1365-2133.1996.d01-1076.x-
dc.identifier.urihttp://hdl.handle.net/10541/95799-
dc.description.abstractThe efficacy and suitability of photodynamic therapy (PDT) was compared with that of cryotherapy in the treatment of 40 lesions of Bowen's disease. Lesions were randomized to receive either cryotherapy with liquid nitrogen, or PDT using a portable desktop lamp incorporating a 300 W xenon short arc discharge source. A porphyrin precursor, 5-aminolaevulinic acid (5-ALA), was applied topically 4 h before irradiation in the PDT group. Each lesion received 125 J/cm2 at a fluence rate of 70 mW/cm2. All patients were reviewed at 2-monthly intervals and treatments repeated if required. Cryotherapy produced clearance in 10 of 20 lesions after one treatment, the remaining 10 lesions requiring two or three treatment applications. PDT resulted in clearance of 15 of 20 lesions after one treatment and of the remaining five lesions after a second treatment. The probability that a lesion cleared after one treatment was greater with PDT than cryotherapy (P < 0.01). Cryotherapy was associated with ulceration (five of 20), infection (two of 20) and recurrent disease (two of 20); no such complications occurred following PDT. PDT using a non-laser light source and topical 5-ALA appears to be at least as effective as cryotherapy in the treatment of Bowen's disease with fewer adverse effects.en
dc.language.isoenen
dc.subjectCancer Recurrenceen
dc.subjectSkin Canceren
dc.subject.meshAged-
dc.subject.meshAged, 80 and over-
dc.subject.meshBowen's Disease-
dc.subject.meshCryotherapy-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshNeoplasm Recurrence, Local-
dc.subject.meshPain-
dc.subject.meshPhotochemotherapy-
dc.subject.meshSkin Neoplasms-
dc.subject.meshTreatment Outcome-
dc.titleComparison of photodynamic therapy with cryotherapy in the treatment of Bowen's disease.en
dc.typeArticleen
dc.contributor.departmentUniversity Department of Dermatology, Western Infirmary, Glasgow, U.K.en
dc.identifier.journalThe British Journal of Dermatologyen

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