Fibroblasts from Li-Fraumeni patients are resistant to low dose-rate irradiation.

2.50
Hdl Handle:
http://hdl.handle.net/10541/95673
Title:
Fibroblasts from Li-Fraumeni patients are resistant to low dose-rate irradiation.
Authors:
Sproston, Anthony R; Boyle, John M; Heighway, Jim; Birch, Jillian M; Scott, David
Abstract:
A group of adult skin fibroblast cultures from four individuals representing Li-Fraumeni families with different mutations in the p53 gene were found to be resistant to low dose-rate (0.011 Gy per min) 60Co radiation when compared with a control group of four cultures from normal individuals. The Li-Fraumeni fibroblasts, which could not be distinguished from controls after high dose rate (1.07 Gy per min) irradiation, were shown to be heterozygous (+/mut) at the p53 locus at the time of irradiation.
Affiliation:
CRC Department of Experimental Radiation Oncology, Paterson Institute for Cancer Research, Manchester, UK.
Citation:
Fibroblasts from Li-Fraumeni patients are resistant to low dose-rate irradiation. 1996, 70 (2):145-50 Int. J. Radiat. Biol.
Journal:
International Journal of Radiation Biology
Issue Date:
Aug-1996
URI:
http://hdl.handle.net/10541/95673
DOI:
10.1080/095530096145139
PubMed ID:
8794843
Type:
Article
Language:
en
ISSN:
0955-3002
Appears in Collections:
All Christie Publications ; All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorSproston, Anthony Ren
dc.contributor.authorBoyle, John Men
dc.contributor.authorHeighway, Jimen
dc.contributor.authorBirch, Jillian Men
dc.contributor.authorScott, Daviden
dc.date.accessioned2010-04-06T10:53:14Z-
dc.date.available2010-04-06T10:53:14Z-
dc.date.issued1996-08-
dc.identifier.citationFibroblasts from Li-Fraumeni patients are resistant to low dose-rate irradiation. 1996, 70 (2):145-50 Int. J. Radiat. Biol.en
dc.identifier.issn0955-3002-
dc.identifier.pmid8794843-
dc.identifier.doi10.1080/095530096145139-
dc.identifier.urihttp://hdl.handle.net/10541/95673-
dc.description.abstractA group of adult skin fibroblast cultures from four individuals representing Li-Fraumeni families with different mutations in the p53 gene were found to be resistant to low dose-rate (0.011 Gy per min) 60Co radiation when compared with a control group of four cultures from normal individuals. The Li-Fraumeni fibroblasts, which could not be distinguished from controls after high dose rate (1.07 Gy per min) irradiation, were shown to be heterozygous (+/mut) at the p53 locus at the time of irradiation.en
dc.language.isoenen
dc.subject.meshAdolescent-
dc.subject.meshAdult-
dc.subject.meshCells, Cultured-
dc.subject.meshChild, Preschool-
dc.subject.meshFemale-
dc.subject.meshFibroblasts-
dc.subject.meshGenes, p53-
dc.subject.meshHumans-
dc.subject.meshLi-Fraumeni Syndrome-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshMutation-
dc.subject.meshRadiation Tolerance-
dc.titleFibroblasts from Li-Fraumeni patients are resistant to low dose-rate irradiation.en
dc.typeArticleen
dc.contributor.departmentCRC Department of Experimental Radiation Oncology, Paterson Institute for Cancer Research, Manchester, UK.en
dc.identifier.journalInternational Journal of Radiation Biologyen

Related articles on PubMed

All Items in Christie are protected by copyright, with all rights reserved, unless otherwise indicated.