Immunogenetic factors in HPV-associated cervical cancer: influence on disease progression.

2.50
Hdl Handle:
http://hdl.handle.net/10541/95625
Title:
Immunogenetic factors in HPV-associated cervical cancer: influence on disease progression.
Authors:
Duggan-Keen, Margaret F; Keating, P J; Stevens, F R Adam; Sinnott, P; Snijders, P J; Walboomers, J M; Davidson, Susan E; Hunter, Robin D; Dyer, P A; Stern, Peter L
Abstract:
No HLA allele or specificity was significantly different in frequency between a group of 150 cervical cancer patients from north-west England and controls (corrected P values). HLA-DRB1*1501/DQB1*0602 was non-significantly increased, particularly among patients with HPV16-positive tumours. HLA-B7-positive patients had a significantly poorer clinical outcome than HLA-B7-negative patients. A significant component of the genotypic effect is down-regulation of HLA-B7 expression by the tumour cells.
Affiliation:
CRC Department of Immunology, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, UK.
Citation:
Immunogenetic factors in HPV-associated cervical cancer: influence on disease progression. 1996, 23 (4):275-84 Eur. J. Immunogenet.
Journal:
European Journal of Immunogenetics
Issue Date:
Aug-1996
URI:
http://hdl.handle.net/10541/95625
PubMed ID:
8858284
Type:
Article
Language:
en
ISSN:
0960-7420
Appears in Collections:
All Christie Publications ; All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorDuggan-Keen, Margaret Fen
dc.contributor.authorKeating, P Jen
dc.contributor.authorStevens, F R Adamen
dc.contributor.authorSinnott, Pen
dc.contributor.authorSnijders, P Jen
dc.contributor.authorWalboomers, J Men
dc.contributor.authorDavidson, Susan Een
dc.contributor.authorHunter, Robin Den
dc.contributor.authorDyer, P Aen
dc.contributor.authorStern, Peter Len
dc.date.accessioned2010-04-06T10:00:25Z-
dc.date.available2010-04-06T10:00:25Z-
dc.date.issued1996-08-
dc.identifier.citationImmunogenetic factors in HPV-associated cervical cancer: influence on disease progression. 1996, 23 (4):275-84 Eur. J. Immunogenet.en
dc.identifier.issn0960-7420-
dc.identifier.pmid8858284-
dc.identifier.urihttp://hdl.handle.net/10541/95625-
dc.description.abstractNo HLA allele or specificity was significantly different in frequency between a group of 150 cervical cancer patients from north-west England and controls (corrected P values). HLA-DRB1*1501/DQB1*0602 was non-significantly increased, particularly among patients with HPV16-positive tumours. HLA-B7-positive patients had a significantly poorer clinical outcome than HLA-B7-negative patients. A significant component of the genotypic effect is down-regulation of HLA-B7 expression by the tumour cells.en
dc.language.isoenen
dc.subjectUterine Cervical Canceren
dc.subjectTumour Virus Infectionsen
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshAged, 80 and over-
dc.subject.meshDisease Progression-
dc.subject.meshFemale-
dc.subject.meshFollow-Up Studies-
dc.subject.meshHistocompatibility Testing-
dc.subject.meshHumans-
dc.subject.meshImmunogenetics-
dc.subject.meshMiddle Aged-
dc.subject.meshPapillomaviridae-
dc.subject.meshPapillomavirus Infections-
dc.subject.meshTumor Virus Infections-
dc.subject.meshUterine Cervical Neoplasms-
dc.titleImmunogenetic factors in HPV-associated cervical cancer: influence on disease progression.en
dc.typeArticleen
dc.contributor.departmentCRC Department of Immunology, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, UK.en
dc.identifier.journalEuropean Journal of Immunogeneticsen

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