2.50
Hdl Handle:
http://hdl.handle.net/10541/95604
Title:
Transferrin-mediated uptake of plutonium by spermatogenic tubules.
Authors:
Hoyes, Katherine P; Bingham, D; Hendry, Jolyon H; Harrison, J D; Sharma, Harbans L; Morris, Ian D
Abstract:
Using isolated rat seminiferous tubules as an in vitro model, we have found that 238Pu can cross the blood-tubule barrier and accumulate within tubules in a time dependent manner. Furthermore, similar to 59Fe, tubule 238Pu uptake was inhibited by the addition of excess transferrin, suggesting that plutonium may utilize the physiological iron-transferrin pathway to cross the blood-tubule barrier. However unlike 59Fe, 238Pu was only transiently associated with the tubules, suggesting differences in the intracellular processing of these radionuclides. The assumptions made in the estimation of doses to the human testis from incorporated plutonium are considered.
Affiliation:
School of Biological Sciences, University of Manchester, UK.
Citation:
Transferrin-mediated uptake of plutonium by spermatogenic tubules. 1996, 70 (4):467-71 Int. J. Radiat. Biol.
Journal:
International Journal of Radiation Biology
Issue Date:
Oct-1996
URI:
http://hdl.handle.net/10541/95604
DOI:
10.1080/095530096144941
PubMed ID:
8862458
Type:
Article
Language:
en
ISSN:
0955-3002
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorHoyes, Katherine Pen
dc.contributor.authorBingham, Den
dc.contributor.authorHendry, Jolyon Hen
dc.contributor.authorHarrison, J Den
dc.contributor.authorSharma, Harbans Len
dc.contributor.authorMorris, Ian Den
dc.date.accessioned2010-04-06T09:28:07Z-
dc.date.available2010-04-06T09:28:07Z-
dc.date.issued1996-10-
dc.identifier.citationTransferrin-mediated uptake of plutonium by spermatogenic tubules. 1996, 70 (4):467-71 Int. J. Radiat. Biol.en
dc.identifier.issn0955-3002-
dc.identifier.pmid8862458-
dc.identifier.doi10.1080/095530096144941-
dc.identifier.urihttp://hdl.handle.net/10541/95604-
dc.description.abstractUsing isolated rat seminiferous tubules as an in vitro model, we have found that 238Pu can cross the blood-tubule barrier and accumulate within tubules in a time dependent manner. Furthermore, similar to 59Fe, tubule 238Pu uptake was inhibited by the addition of excess transferrin, suggesting that plutonium may utilize the physiological iron-transferrin pathway to cross the blood-tubule barrier. However unlike 59Fe, 238Pu was only transiently associated with the tubules, suggesting differences in the intracellular processing of these radionuclides. The assumptions made in the estimation of doses to the human testis from incorporated plutonium are considered.en
dc.language.isoenen
dc.subject.meshAnimals-
dc.subject.meshEndocytosis-
dc.subject.meshEpithelium-
dc.subject.meshGap Junctions-
dc.subject.meshHumans-
dc.subject.meshIodine Radioisotopes-
dc.subject.meshMale-
dc.subject.meshPlutonium-
dc.subject.meshRats-
dc.subject.meshRats, Sprague-Dawley-
dc.subject.meshSeminiferous Tubules-
dc.subject.meshTransferrin-
dc.titleTransferrin-mediated uptake of plutonium by spermatogenic tubules.en
dc.typeArticleen
dc.contributor.departmentSchool of Biological Sciences, University of Manchester, UK.en
dc.identifier.journalInternational Journal of Radiation Biologyen

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