Allelic imbalance in the region of the BRCA1 gene in ductal carcinoma in situ of the breast.

2.50
Hdl Handle:
http://hdl.handle.net/10541/95600
Title:
Allelic imbalance in the region of the BRCA1 gene in ductal carcinoma in situ of the breast.
Authors:
Munn, K E; Walker, R A; Menasce, Lia P; Varley, Jennifer
Abstract:
Thirty-four cases of ductal carcinoma in situ (DCIS) of the breast, with or without associated benign or invasive disease, were analysed for allelic imbalance (AI) in the region of the BRCA1 gene. AI on 17q12-23 in DCIS was demonstrated in 74% of cases, and in the majority of cases the region of AI included the BRCA1 gene. However, two cases showed AI distal to BRCA1, supporting the presence of a second tumour-suppressor gene on 17q.
Affiliation:
CRC Department of Cancer Genetics, Paterson Institute for Cancer Research, Christie Hospital, Manchester, UK.
Citation:
Allelic imbalance in the region of the BRCA1 gene in ductal carcinoma in situ of the breast. 1996, 73 (5):636-9 Br. J. Cancer
Journal:
British Journal of Cancer
Issue Date:
Mar-1996
URI:
http://hdl.handle.net/10541/95600
PubMed ID:
8605099
Type:
Article
Language:
en
ISSN:
0007-0920
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorMunn, K Een
dc.contributor.authorWalker, R Aen
dc.contributor.authorMenasce, Lia Pen
dc.contributor.authorVarley, Jenniferen
dc.date.accessioned2010-04-06T09:07:17Z-
dc.date.available2010-04-06T09:07:17Z-
dc.date.issued1996-03-
dc.identifier.citationAllelic imbalance in the region of the BRCA1 gene in ductal carcinoma in situ of the breast. 1996, 73 (5):636-9 Br. J. Canceren
dc.identifier.issn0007-0920-
dc.identifier.pmid8605099-
dc.identifier.urihttp://hdl.handle.net/10541/95600-
dc.description.abstractThirty-four cases of ductal carcinoma in situ (DCIS) of the breast, with or without associated benign or invasive disease, were analysed for allelic imbalance (AI) in the region of the BRCA1 gene. AI on 17q12-23 in DCIS was demonstrated in 74% of cases, and in the majority of cases the region of AI included the BRCA1 gene. However, two cases showed AI distal to BRCA1, supporting the presence of a second tumour-suppressor gene on 17q.en
dc.language.isoenen
dc.subjectBreast Canceren
dc.subjectCancer Proteinsen
dc.subject.meshAlleles-
dc.subject.meshBRCA1 Protein-
dc.subject.meshBreast Neoplasms-
dc.subject.meshCarcinoma in Situ-
dc.subject.meshCarcinoma, Ductal, Breast-
dc.subject.meshChromosomes, Human, Pair 17-
dc.subject.meshFemale-
dc.subject.meshGenes, erbB-2-
dc.subject.meshHumans-
dc.subject.meshNeoplasm Proteins-
dc.subject.meshTranscription Factors-
dc.titleAllelic imbalance in the region of the BRCA1 gene in ductal carcinoma in situ of the breast.en
dc.typeArticleen
dc.contributor.departmentCRC Department of Cancer Genetics, Paterson Institute for Cancer Research, Christie Hospital, Manchester, UK.en
dc.identifier.journalBritish Journal of Canceren

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