Cell kinetics in rat small intestine after exposure to 3 Gy of gamma-rays at different times of the day.

2.50
Hdl Handle:
http://hdl.handle.net/10541/95511
Title:
Cell kinetics in rat small intestine after exposure to 3 Gy of gamma-rays at different times of the day.
Authors:
Becciolini, A; Balzi, M; Fabbrica, D; Potten, Christopher S
Abstract:
Qualitative and quantitative morphological changes in rat jejunum were studied after a whole-body exposure to 3 Gy of gamma rays. Four groups of animals were irradiated at different times of the day, namely midnight, 06.00, 12.00 and 18.00 hours. The number of epithelial cells, labelling and mitotic indices were evaluated in crypt sections and the spatial distribution of S-phase cells was determined. At 12 h after irradiation a marked reduction was observed in all parameters, but the proliferative activity was restored quickly and at 36 h after irradiation the values were significantly higher than the controls. The frequency distribution of labelled cells at different positions in the crypt was reduced at 12 h but a clear expansion of S phase cells to positions near to the crypt villus junction was observed during the recovery phase. The animals irradiated at different times of the day showed a similar general post-irradiation response in the number of cells along the side of the crypt, labelling and mitotic indices and in the distribution of S phase cells along the crypts. It is worth noting that the animals exposed at midnight had a distribution of S phase cells similar to controls at 72 h post-irradiation, i.e. earlier than the other groups.
Affiliation:
Department of Clinical Physiopathology, University of Florence, Italy.
Citation:
Cell kinetics in rat small intestine after exposure to 3 Gy of gamma-rays at different times of the day. 1996, 70 (3):281-8 Int. J. Radiat. Biol.
Journal:
International Journal of Radiation Biology
Issue Date:
Sep-1996
URI:
http://hdl.handle.net/10541/95511
DOI:
10.1080/095530096145012
PubMed ID:
8800199
Type:
Article
Language:
en
ISSN:
0955-3002
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorBecciolini, Aen
dc.contributor.authorBalzi, Men
dc.contributor.authorFabbrica, Den
dc.contributor.authorPotten, Christopher Sen
dc.date.accessioned2010-04-01T15:32:58Z-
dc.date.available2010-04-01T15:32:58Z-
dc.date.issued1996-09-
dc.identifier.citationCell kinetics in rat small intestine after exposure to 3 Gy of gamma-rays at different times of the day. 1996, 70 (3):281-8 Int. J. Radiat. Biol.en
dc.identifier.issn0955-3002-
dc.identifier.pmid8800199-
dc.identifier.doi10.1080/095530096145012-
dc.identifier.urihttp://hdl.handle.net/10541/95511-
dc.description.abstractQualitative and quantitative morphological changes in rat jejunum were studied after a whole-body exposure to 3 Gy of gamma rays. Four groups of animals were irradiated at different times of the day, namely midnight, 06.00, 12.00 and 18.00 hours. The number of epithelial cells, labelling and mitotic indices were evaluated in crypt sections and the spatial distribution of S-phase cells was determined. At 12 h after irradiation a marked reduction was observed in all parameters, but the proliferative activity was restored quickly and at 36 h after irradiation the values were significantly higher than the controls. The frequency distribution of labelled cells at different positions in the crypt was reduced at 12 h but a clear expansion of S phase cells to positions near to the crypt villus junction was observed during the recovery phase. The animals irradiated at different times of the day showed a similar general post-irradiation response in the number of cells along the side of the crypt, labelling and mitotic indices and in the distribution of S phase cells along the crypts. It is worth noting that the animals exposed at midnight had a distribution of S phase cells similar to controls at 72 h post-irradiation, i.e. earlier than the other groups.en
dc.language.isoenen
dc.subject.meshAnimals-
dc.subject.meshCell Division-
dc.subject.meshEpithelium-
dc.subject.meshFemale-
dc.subject.meshGamma Rays-
dc.subject.meshIntestine, Small-
dc.subject.meshRats-
dc.subject.meshRats, Wistar-
dc.subject.meshTime Factors-
dc.titleCell kinetics in rat small intestine after exposure to 3 Gy of gamma-rays at different times of the day.en
dc.typeArticleen
dc.contributor.departmentDepartment of Clinical Physiopathology, University of Florence, Italy.en
dc.identifier.journalInternational Journal of Radiation Biologyen
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