Low dose hyper-radiosensitivity and increased radioresistance in mammalian cells.

2.50
Hdl Handle:
http://hdl.handle.net/10541/95497
Title:
Low dose hyper-radiosensitivity and increased radioresistance in mammalian cells.
Authors:
Marples, B; Lambin, P; Skov, K A; Joiner, M C
Abstract:
This manuscript reviews the low-dose survival work using the DMIPS cell analyser that has been carried out at the Gray Laboratory in the U.K. and the British Columbia Cancer Research Centre in Canada. It describes low dose hyper-radiosensitivity (HRS) detected after single doses of X-rays less than approximately 0.3 Gy and the subsequent increased radioresistant response (IRR) seen as the dose increases up to 1 Gy. Work is summarized from studies in V79 cells, normal human and human tumour cell lines and mutant cell lines deficient in DNA repair. The data are considered in light of the hypothesis that hyper-radiosensitivity and increased radioresistance reflect the existence of an inducible protective mechanism, possibly triggered by DNA damage.
Affiliation:
Department of Experimental Radiation Oncology, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, U.K.
Citation:
Low dose hyper-radiosensitivity and increased radioresistance in mammalian cells. 1997, 71 (6):721-35 Int. J. Radiat. Biol.
Journal:
International Journal of Radiation Biology
Issue Date:
Jun-1997
URI:
http://hdl.handle.net/10541/95497
PubMed ID:
9246186
Type:
Article
Language:
en
ISSN:
0955-3002
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorMarples, Ben
dc.contributor.authorLambin, Pen
dc.contributor.authorSkov, K Aen
dc.contributor.authorJoiner, M Cen
dc.date.accessioned2010-04-01T13:55:33Z-
dc.date.available2010-04-01T13:55:33Z-
dc.date.issued1997-06-
dc.identifier.citationLow dose hyper-radiosensitivity and increased radioresistance in mammalian cells. 1997, 71 (6):721-35 Int. J. Radiat. Biol.en
dc.identifier.issn0955-3002-
dc.identifier.pmid9246186-
dc.identifier.urihttp://hdl.handle.net/10541/95497-
dc.description.abstractThis manuscript reviews the low-dose survival work using the DMIPS cell analyser that has been carried out at the Gray Laboratory in the U.K. and the British Columbia Cancer Research Centre in Canada. It describes low dose hyper-radiosensitivity (HRS) detected after single doses of X-rays less than approximately 0.3 Gy and the subsequent increased radioresistant response (IRR) seen as the dose increases up to 1 Gy. Work is summarized from studies in V79 cells, normal human and human tumour cell lines and mutant cell lines deficient in DNA repair. The data are considered in light of the hypothesis that hyper-radiosensitivity and increased radioresistance reflect the existence of an inducible protective mechanism, possibly triggered by DNA damage.en
dc.language.isoenen
dc.subject.meshAnimals-
dc.subject.meshCell Survival-
dc.subject.meshCells, Cultured-
dc.subject.meshCricetinae-
dc.subject.meshDNA Damage-
dc.subject.meshDNA Repair-
dc.subject.meshDose-Response Relationship, Radiation-
dc.subject.meshHumans-
dc.subject.meshLymphocytes-
dc.subject.meshMice-
dc.subject.meshNeutrons-
dc.subject.meshX-Rays-
dc.titleLow dose hyper-radiosensitivity and increased radioresistance in mammalian cells.en
dc.typeArticleen
dc.contributor.departmentDepartment of Experimental Radiation Oncology, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, U.K.en
dc.identifier.journalInternational Journal of Radiation Biologyen
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