2.50
Hdl Handle:
http://hdl.handle.net/10541/95494
Title:
The intestinal epithelial stem cell: the mucosal governor.
Authors:
Potten, Christopher S; Booth, Catherine; Pritchard, D M
Abstract:
All epithelial cells in the small and large intestine are thought to originate from stem cells located towards the base of the crypts of Lieberkühn. To-date, there are no specific intestinal stem cell markers, hence stem cell properties can only be inferred. A range of experimental techniques have been employed including cell position mapping, radiation regeneration (clonogenic) assays, chimeric and transgenic mice. This review discusses the implications of experiments performed using these techniques in order to deduce the number, location and functional properties of stem cells. Stem cell homeostasis is maintained by cell proliferation and death 'through apoptosis'. The various growth and matrix factors and genes which may control these processes, and be important for stem cell function, are discussed along with their carcinogenic and clinical implications.
Affiliation:
CRC Department of Epithelial Biology, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Withington, Manchester, UK. epbcsp@picr.man.ac.uk
Citation:
The intestinal epithelial stem cell: the mucosal governor. 1997, 78 (4):219-43 Int J Exp Pathol
Journal:
International Journal of Experimental Pathology
Issue Date:
Aug-1997
URI:
http://hdl.handle.net/10541/95494
DOI:
10.1046/j.1365-2613.1997.280362.x
PubMed ID:
9505935
Type:
Article
Language:
en
ISSN:
0959-9673
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorPotten, Christopher Sen
dc.contributor.authorBooth, Catherineen
dc.contributor.authorPritchard, D Men
dc.date.accessioned2010-04-01T13:43:42Z-
dc.date.available2010-04-01T13:43:42Z-
dc.date.issued1997-08-
dc.identifier.citationThe intestinal epithelial stem cell: the mucosal governor. 1997, 78 (4):219-43 Int J Exp Patholen
dc.identifier.issn0959-9673-
dc.identifier.pmid9505935-
dc.identifier.doi10.1046/j.1365-2613.1997.280362.x-
dc.identifier.urihttp://hdl.handle.net/10541/95494-
dc.description.abstractAll epithelial cells in the small and large intestine are thought to originate from stem cells located towards the base of the crypts of Lieberkühn. To-date, there are no specific intestinal stem cell markers, hence stem cell properties can only be inferred. A range of experimental techniques have been employed including cell position mapping, radiation regeneration (clonogenic) assays, chimeric and transgenic mice. This review discusses the implications of experiments performed using these techniques in order to deduce the number, location and functional properties of stem cells. Stem cell homeostasis is maintained by cell proliferation and death 'through apoptosis'. The various growth and matrix factors and genes which may control these processes, and be important for stem cell function, are discussed along with their carcinogenic and clinical implications.en
dc.language.isoenen
dc.subject.meshAnimals-
dc.subject.meshApoptosis-
dc.subject.meshCell Count-
dc.subject.meshCell Differentiation-
dc.subject.meshCell Division-
dc.subject.meshEpithelial Cells-
dc.subject.meshHumans-
dc.subject.meshIntestinal Mucosa-
dc.subject.meshMice-
dc.subject.meshStem Cells-
dc.titleThe intestinal epithelial stem cell: the mucosal governor.en
dc.typeArticleen
dc.contributor.departmentCRC Department of Epithelial Biology, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Withington, Manchester, UK. epbcsp@picr.man.ac.uken
dc.identifier.journalInternational Journal of Experimental Pathologyen

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