Accumulation of p53 in relation to long-term prognosis in colorectal carcinoma.

2.50
Hdl Handle:
http://hdl.handle.net/10541/95473
Title:
Accumulation of p53 in relation to long-term prognosis in colorectal carcinoma.
Authors:
Starzynska, T; Bromley, Michael; Marlicz, K; Roberts, Stephen A; Ucinski, M; Stern, Peter L
Abstract:
OBJECTIVE: To evaluate the prognostic value of p53 in colorectal cancer. DESIGN: A retrospective study to investigate the correlation between p53 in tumour tissue and the course of patients' disease. PATIENTS: One hundred and two patients who underwent radical surgery for colorectal cancer and were followed up for a minimum of 5 years, or until death, were included in this study. METHODS: The p53 expression in tumour tissue was studied by immunohistochemistry using CM1 polyclonal rabbit antibody and formalin-fixed, paraffin-embedded material. RESULTS: p53 accumulation was detected in 46% (47/102) of the tumours. There was no significant difference in long-term survival between the patients with p53 positive and negative tumours (P=0.86). Five-year survival rates were 55% for p53 positive tumours compared with 56% for patients with p53 negative tumours. However, patients with p53 overexpressing tumours showed a higher local recurrence rate than those having carcinomas with undetectable levels of p53, 23% versus 9% respectively; the 2-year actuarial rates of 26% and 9% were statistically different (P=0.015). CONCLUSION: The results suggest that in colorectal carcinoma accumulation of p53 is not associated with a difference in long-term prognosis. However, this phenomenon might be useful in the identification of patients with a high risk of local recurrence.
Affiliation:
Department of Gastroenterology Medical Pomeranian Academy, Unii Lubelskiej, Poland.
Citation:
Accumulation of p53 in relation to long-term prognosis in colorectal carcinoma. 1997, 9 (2):183-6 Eur J Gastroenterol Hepatol
Journal:
European Journal of Gastroenterology & Hepatology
Issue Date:
Feb-1997
URI:
http://hdl.handle.net/10541/95473
PubMed ID:
9058631
Type:
Article
Language:
en
ISSN:
0954-691X
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorStarzynska, Ten
dc.contributor.authorBromley, Michaelen
dc.contributor.authorMarlicz, Ken
dc.contributor.authorRoberts, Stephen Aen
dc.contributor.authorUcinski, Men
dc.contributor.authorStern, Peter Len
dc.date.accessioned2010-04-01T13:27:44Z-
dc.date.available2010-04-01T13:27:44Z-
dc.date.issued1997-02-
dc.identifier.citationAccumulation of p53 in relation to long-term prognosis in colorectal carcinoma. 1997, 9 (2):183-6 Eur J Gastroenterol Hepatolen
dc.identifier.issn0954-691X-
dc.identifier.pmid9058631-
dc.identifier.urihttp://hdl.handle.net/10541/95473-
dc.description.abstractOBJECTIVE: To evaluate the prognostic value of p53 in colorectal cancer. DESIGN: A retrospective study to investigate the correlation between p53 in tumour tissue and the course of patients' disease. PATIENTS: One hundred and two patients who underwent radical surgery for colorectal cancer and were followed up for a minimum of 5 years, or until death, were included in this study. METHODS: The p53 expression in tumour tissue was studied by immunohistochemistry using CM1 polyclonal rabbit antibody and formalin-fixed, paraffin-embedded material. RESULTS: p53 accumulation was detected in 46% (47/102) of the tumours. There was no significant difference in long-term survival between the patients with p53 positive and negative tumours (P=0.86). Five-year survival rates were 55% for p53 positive tumours compared with 56% for patients with p53 negative tumours. However, patients with p53 overexpressing tumours showed a higher local recurrence rate than those having carcinomas with undetectable levels of p53, 23% versus 9% respectively; the 2-year actuarial rates of 26% and 9% were statistically different (P=0.015). CONCLUSION: The results suggest that in colorectal carcinoma accumulation of p53 is not associated with a difference in long-term prognosis. However, this phenomenon might be useful in the identification of patients with a high risk of local recurrence.en
dc.language.isoenen
dc.subjectColorectal Canceren
dc.subjectTumour Suppressor Protein p53en
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshBiological Markers-
dc.subject.meshColorectal Neoplasms-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshImmunohistochemistry-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshPrognosis-
dc.subject.meshRetrospective Studies-
dc.subject.meshSurvival Analysis-
dc.subject.meshTumor Suppressor Protein p53-
dc.titleAccumulation of p53 in relation to long-term prognosis in colorectal carcinoma.en
dc.typeArticleen
dc.contributor.departmentDepartment of Gastroenterology Medical Pomeranian Academy, Unii Lubelskiej, Poland.en
dc.identifier.journalEuropean Journal of Gastroenterology & Hepatologyen

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