The role of radiation-induced and spontaneous apoptosis in the homeostasis of the gastrointestinal epithelium: a brief review.

2.50
Hdl Handle:
http://hdl.handle.net/10541/95442
Title:
The role of radiation-induced and spontaneous apoptosis in the homeostasis of the gastrointestinal epithelium: a brief review.
Authors:
Potten, Christopher S; Booth, Catherine
Abstract:
Until fairly recently, investigations into the control of cell production (proliferation) have been the mainstay of studies into the maintenance of mucosal homeostasis and general integrity. However, in addition to proliferation, it is now increasingly evident that programmed cell death, specifically that form of programmed cell death known as apoptosis, is an equally, if not more important, mechanism of regulating mucosal cell number. This review will concentrate on the significance of damage (radiation) induced and spontaneous apoptosis in the maintenance of intestinal epithelial stem cell number and integrity, and its probable link to the level of cancer incidence in the small intestine and colon.
Affiliation:
CRC Department of Epithelial Biology, Paterson Institute for Cancer Research, Christie Hospital (NHS) Trust, Manchester, U.K. epbcsp@picr.cr.man.ac.uk
Citation:
The role of radiation-induced and spontaneous apoptosis in the homeostasis of the gastrointestinal epithelium: a brief review. 1997, 118 (3):473-8 Comp. Biochem. Physiol. B, Biochem. Mol. Biol.
Journal:
Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
Issue Date:
Nov-1997
URI:
http://hdl.handle.net/10541/95442
DOI:
10.1016/S0305-0491(97)00219-8
PubMed ID:
9467859
Type:
Article
Language:
en
ISSN:
1096-4959
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorPotten, Christopher Sen
dc.contributor.authorBooth, Catherineen
dc.date.accessioned2010-04-01T11:16:47Z-
dc.date.available2010-04-01T11:16:47Z-
dc.date.issued1997-11-
dc.identifier.citationThe role of radiation-induced and spontaneous apoptosis in the homeostasis of the gastrointestinal epithelium: a brief review. 1997, 118 (3):473-8 Comp. Biochem. Physiol. B, Biochem. Mol. Biol.en
dc.identifier.issn1096-4959-
dc.identifier.pmid9467859-
dc.identifier.doi10.1016/S0305-0491(97)00219-8-
dc.identifier.urihttp://hdl.handle.net/10541/95442-
dc.description.abstractUntil fairly recently, investigations into the control of cell production (proliferation) have been the mainstay of studies into the maintenance of mucosal homeostasis and general integrity. However, in addition to proliferation, it is now increasingly evident that programmed cell death, specifically that form of programmed cell death known as apoptosis, is an equally, if not more important, mechanism of regulating mucosal cell number. This review will concentrate on the significance of damage (radiation) induced and spontaneous apoptosis in the maintenance of intestinal epithelial stem cell number and integrity, and its probable link to the level of cancer incidence in the small intestine and colon.en
dc.language.isoenen
dc.subjectColonic Canceren
dc.subject.meshAnimals-
dc.subject.meshApoptosis-
dc.subject.meshColonic Neoplasms-
dc.subject.meshDigestive System Physiological Phenomena-
dc.subject.meshEpithelial Cells-
dc.titleThe role of radiation-induced and spontaneous apoptosis in the homeostasis of the gastrointestinal epithelium: a brief review.en
dc.typeArticleen
dc.contributor.departmentCRC Department of Epithelial Biology, Paterson Institute for Cancer Research, Christie Hospital (NHS) Trust, Manchester, U.K. epbcsp@picr.cr.man.ac.uken
dc.identifier.journalComparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biologyen
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