Low intercellular adhesion molecule 1 and high 5T4 expression on tumor cells correlate with reduced disease-free survival in colorectal carcinoma patients.

2.50
Hdl Handle:
http://hdl.handle.net/10541/95249
Title:
Low intercellular adhesion molecule 1 and high 5T4 expression on tumor cells correlate with reduced disease-free survival in colorectal carcinoma patients.
Authors:
Mulder, W M; Stern, Peter L; Stukart, M J; De Windt, E; Butzelaar, R M; Meijer, S; Adér, H J; Claessen, A M; Vermorken, J B; Meijer, C J; Wagstaff, John; Scheper, R J; Bloemena, E
Abstract:
The purpose of this study was to investigate the prognostic value of the expression of intercellular adhesion molecule 1 (ICAM-1), leukocyte function antigen 3 (LFA-3), human leukocyte differentiation antigen (HLA)-ABC, HLA-DR, and 5T4 with regard to disease-free survival in Dukes' B and C colorectal carcinoma patients. Forty-one patients (28 Dukes' B and 13 Dukes' C) were entered into this study. Immunocytochemistry was performed on cytospin preparations of enzymatically digested colorectal carcinoma cell suspensions. The frequency of metastases and the duration of disease-free survival were compared between the 25% lowest expressers and the 75% remaining patients for ICAM-1, LFA-3, HLA-ABC, and HLA-DR, and between the 25% highest expressers and the 75% remaining patients for 5T4. Low numbers of ICAM-1-expressing tumor cells were associated with a shorter disease-free survival (P < 0. 001), independent of Dukes' stage. High numbers of 5T4-expressing tumor cells were associated with shorter disease-free survival in Dukes' B patients (P = 0.04). Cox proportional hazard analysis indicated that low numbers of ICAM-1(+) and high numbers of 5T4(+) cells were independent prognostic factors with relative risks of 13. 0 (P = 0.0002) and 4.7 (P = 0.02), respectively. The combination of 5T4 and ICAM-1 marker information identified subgroups of patients with a good (high ICAM-1) or poor (low ICAM-1/high 5T4) prognosis. Neither a lack of HLA-ABC and LFA-3 expression nor the presence of HLA-DR on the tumor cells gave additional prognostic information. These findings demonstrate that low ICAM-1 and high 5T4 expression on tumor cells are prognostic markers, additional to Dukes' stage, for reduced disease-free survival in Dukes' B and C colorectal carcinoma patients.
Affiliation:
Departments of Pathology, Surgery, and Oncology, Free University Hospital, 1081 HV Amsterdam, The Netherlands.
Citation:
Low intercellular adhesion molecule 1 and high 5T4 expression on tumor cells correlate with reduced disease-free survival in colorectal carcinoma patients. 1997, 3 (11):1923-30 Clin. Cancer Res.
Journal:
Clinical Cancer Research
Issue Date:
Nov-1997
URI:
http://hdl.handle.net/10541/95249
PubMed ID:
9815581
Type:
Article
Language:
en
ISSN:
1078-0432
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorMulder, W Men
dc.contributor.authorStern, Peter Len
dc.contributor.authorStukart, M Jen
dc.contributor.authorDe Windt, Een
dc.contributor.authorButzelaar, R Men
dc.contributor.authorMeijer, Sen
dc.contributor.authorAdér, H Jen
dc.contributor.authorClaessen, A Men
dc.contributor.authorVermorken, J Ben
dc.contributor.authorMeijer, C Jen
dc.contributor.authorWagstaff, Johnen
dc.contributor.authorScheper, R Jen
dc.contributor.authorBloemena, Een
dc.date.accessioned2010-03-30T13:56:51Z-
dc.date.available2010-03-30T13:56:51Z-
dc.date.issued1997-11-
dc.identifier.citationLow intercellular adhesion molecule 1 and high 5T4 expression on tumor cells correlate with reduced disease-free survival in colorectal carcinoma patients. 1997, 3 (11):1923-30 Clin. Cancer Res.en
dc.identifier.issn1078-0432-
dc.identifier.pmid9815581-
dc.identifier.urihttp://hdl.handle.net/10541/95249-
dc.description.abstractThe purpose of this study was to investigate the prognostic value of the expression of intercellular adhesion molecule 1 (ICAM-1), leukocyte function antigen 3 (LFA-3), human leukocyte differentiation antigen (HLA)-ABC, HLA-DR, and 5T4 with regard to disease-free survival in Dukes' B and C colorectal carcinoma patients. Forty-one patients (28 Dukes' B and 13 Dukes' C) were entered into this study. Immunocytochemistry was performed on cytospin preparations of enzymatically digested colorectal carcinoma cell suspensions. The frequency of metastases and the duration of disease-free survival were compared between the 25% lowest expressers and the 75% remaining patients for ICAM-1, LFA-3, HLA-ABC, and HLA-DR, and between the 25% highest expressers and the 75% remaining patients for 5T4. Low numbers of ICAM-1-expressing tumor cells were associated with a shorter disease-free survival (P < 0. 001), independent of Dukes' stage. High numbers of 5T4-expressing tumor cells were associated with shorter disease-free survival in Dukes' B patients (P = 0.04). Cox proportional hazard analysis indicated that low numbers of ICAM-1(+) and high numbers of 5T4(+) cells were independent prognostic factors with relative risks of 13. 0 (P = 0.0002) and 4.7 (P = 0.02), respectively. The combination of 5T4 and ICAM-1 marker information identified subgroups of patients with a good (high ICAM-1) or poor (low ICAM-1/high 5T4) prognosis. Neither a lack of HLA-ABC and LFA-3 expression nor the presence of HLA-DR on the tumor cells gave additional prognostic information. These findings demonstrate that low ICAM-1 and high 5T4 expression on tumor cells are prognostic markers, additional to Dukes' stage, for reduced disease-free survival in Dukes' B and C colorectal carcinoma patients.en
dc.language.isoenen
dc.subjectCancer Antigensen
dc.subjectCancer Stagingen
dc.subjectColorectal Canceren
dc.subject.meshAged-
dc.subject.meshAntigens, CD58-
dc.subject.meshAntigens, Neoplasm-
dc.subject.meshBlood Transfusion-
dc.subject.meshColorectal Neoplasms-
dc.subject.meshDisease-Free Survival-
dc.subject.meshFemale-
dc.subject.meshFollow-Up Studies-
dc.subject.meshHLA-DR Antigens-
dc.subject.meshHistocompatibility Antigens Class I-
dc.subject.meshHumans-
dc.subject.meshIntercellular Adhesion Molecule-1-
dc.subject.meshMale-
dc.subject.meshMembrane Glycoproteins-
dc.subject.meshNeoplasm Staging-
dc.subject.meshProportional Hazards Models-
dc.subject.meshSurvival Rate-
dc.subject.meshTime Factors-
dc.titleLow intercellular adhesion molecule 1 and high 5T4 expression on tumor cells correlate with reduced disease-free survival in colorectal carcinoma patients.en
dc.typeArticleen
dc.contributor.departmentDepartments of Pathology, Surgery, and Oncology, Free University Hospital, 1081 HV Amsterdam, The Netherlands.en
dc.identifier.journalClinical Cancer Researchen

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