Generation of a contig comprising YACs and BACs within chromosome region 1p13.1.

2.50
Hdl Handle:
http://hdl.handle.net/10541/95213
Title:
Generation of a contig comprising YACs and BACs within chromosome region 1p13.1.
Authors:
Brintnell, Bill; Hey, Yvonne; Jones, David; Hoggard, Nigel; James, Louise A; Varley, Jennifer
Abstract:
Chromosome region 1p13 is known to show loss of heterozygosity (LOH) in a number of human tumor types, including breast. We have generated a contig comprising YACs and BACs spanning part of 1p13.1 which includes the smallest region of overlapping loss identified in our earlier studies. The contig is anchored to the genetic map by a number of microsatellite markers, and by the use of CEPH YACs. We have excluded a number of candidate genes from this region, and we have oriented the contig with respect to the centromere and a number of other genes and markers on 1p13. This resource will be valuable in mapping the target for LOH in breast and other tumors, and may also be useful for the genetic analysis of other genes or diseases known to map to this region.
Affiliation:
CRC Department of Cancer Genetics, Paterson Institute for Cancer Research, Manchester, UK.
Citation:
Generation of a contig comprising YACs and BACs within chromosome region 1p13.1. 1997, 23 (2):153-7 Somat. Cell Mol. Genet.
Journal:
Somatic Cell and Molecular Genetics
Issue Date:
Mar-1997
URI:
http://hdl.handle.net/10541/95213
DOI:
10.1007/BF02679974
PubMed ID:
9330643
Type:
Article
Language:
en
ISSN:
0740-7750
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorBrintnell, Billen
dc.contributor.authorHey, Yvonneen
dc.contributor.authorJones, Daviden
dc.contributor.authorHoggard, Nigelen
dc.contributor.authorJames, Louise Aen
dc.contributor.authorVarley, Jenniferen
dc.date.accessioned2010-03-30T08:30:04Z-
dc.date.available2010-03-30T08:30:04Z-
dc.date.issued1997-03-
dc.identifier.citationGeneration of a contig comprising YACs and BACs within chromosome region 1p13.1. 1997, 23 (2):153-7 Somat. Cell Mol. Genet.en
dc.identifier.issn0740-7750-
dc.identifier.pmid9330643-
dc.identifier.doi10.1007/BF02679974-
dc.identifier.urihttp://hdl.handle.net/10541/95213-
dc.description.abstractChromosome region 1p13 is known to show loss of heterozygosity (LOH) in a number of human tumor types, including breast. We have generated a contig comprising YACs and BACs spanning part of 1p13.1 which includes the smallest region of overlapping loss identified in our earlier studies. The contig is anchored to the genetic map by a number of microsatellite markers, and by the use of CEPH YACs. We have excluded a number of candidate genes from this region, and we have oriented the contig with respect to the centromere and a number of other genes and markers on 1p13. This resource will be valuable in mapping the target for LOH in breast and other tumors, and may also be useful for the genetic analysis of other genes or diseases known to map to this region.en
dc.language.isoenen
dc.subject.meshChromosome Mapping-
dc.subject.meshChromosomes, Artificial, Yeast-
dc.subject.meshChromosomes, Bacterial-
dc.subject.meshChromosomes, Human, Pair 1-
dc.subject.meshHumans-
dc.subject.meshIn Situ Hybridization, Fluorescence-
dc.subject.meshLoss of Heterozygosity-
dc.subject.meshPolymerase Chain Reaction-
dc.subject.meshSequence Tagged Sites-
dc.titleGeneration of a contig comprising YACs and BACs within chromosome region 1p13.1.en
dc.typeArticleen
dc.contributor.departmentCRC Department of Cancer Genetics, Paterson Institute for Cancer Research, Manchester, UK.en
dc.identifier.journalSomatic Cell and Molecular Geneticsen

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