Nitrosated glycine derivatives as a potential source of O6-methylguanine in DNA.

2.50
Hdl Handle:
http://hdl.handle.net/10541/95196
Title:
Nitrosated glycine derivatives as a potential source of O6-methylguanine in DNA.
Authors:
Shuker, D E; Margison, Geoffrey P
Abstract:
The nitrosated bile acid conjugate N-nitrosoglycocholic acid reacts with DNA to give, rise to several adducts including O6-carboxymethylguanine and, unexpectedly, O6-methylguanine (O6-MG). O6-MG is well established as a toxic and promutagenic lesion and is a substrate for the DNA repair protein O6-alkylguanine-DNA-alkyltransferase. In contrast, O6-carboxymethylguanine is not repaired by this protein. Similar results have been obtained for other nitrosated glycine derivatives, which suggests that O6-MG, which has been observed in DNA from human gastrointestinal tissues, may be derived from intragastric nitrosation of glycine or related compounds.
Affiliation:
MRC Toxicology Unit, Hodgkin Building, University of Leicester, United Kingdom.
Citation:
Nitrosated glycine derivatives as a potential source of O6-methylguanine in DNA. 1997, 57 (3):366-9 Cancer Res.
Journal:
Cancer Research
Issue Date:
1-Feb-1997
URI:
http://hdl.handle.net/10541/95196
PubMed ID:
9012456
Type:
Article
Language:
en
ISSN:
0008-5472
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorShuker, D Een
dc.contributor.authorMargison, Geoffrey Pen
dc.date.accessioned2010-03-29T15:09:58Z-
dc.date.available2010-03-29T15:09:58Z-
dc.date.issued1997-02-01-
dc.identifier.citationNitrosated glycine derivatives as a potential source of O6-methylguanine in DNA. 1997, 57 (3):366-9 Cancer Res.en
dc.identifier.issn0008-5472-
dc.identifier.pmid9012456-
dc.identifier.urihttp://hdl.handle.net/10541/95196-
dc.description.abstractThe nitrosated bile acid conjugate N-nitrosoglycocholic acid reacts with DNA to give, rise to several adducts including O6-carboxymethylguanine and, unexpectedly, O6-methylguanine (O6-MG). O6-MG is well established as a toxic and promutagenic lesion and is a substrate for the DNA repair protein O6-alkylguanine-DNA-alkyltransferase. In contrast, O6-carboxymethylguanine is not repaired by this protein. Similar results have been obtained for other nitrosated glycine derivatives, which suggests that O6-MG, which has been observed in DNA from human gastrointestinal tissues, may be derived from intragastric nitrosation of glycine or related compounds.en
dc.language.isoenen
dc.subject.meshDNA-
dc.subject.meshGlycine-
dc.subject.meshGuanine-
dc.subject.meshHumans-
dc.subject.meshNitrosamines-
dc.titleNitrosated glycine derivatives as a potential source of O6-methylguanine in DNA.en
dc.typeArticleen
dc.contributor.departmentMRC Toxicology Unit, Hodgkin Building, University of Leicester, United Kingdom.en
dc.identifier.journalCancer Researchen
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