Tumour angiogenesis as a prognostic marker in infiltrating lobular carcinoma of the breast.

2.50
Hdl Handle:
http://hdl.handle.net/10541/95174
Title:
Tumour angiogenesis as a prognostic marker in infiltrating lobular carcinoma of the breast.
Authors:
Morphopoulos, G; Pearson, M; Ryder, W David J; Howell, Anthony ( 0000-0002-3879-5991 ) ; Harris, Martin
Abstract:
The importance of angiogenesis, assessed by tumour microvessel density, as a marker of survival was examined in 160 patients with infiltrating lobular carcinoma of the breast (ILC). The median follow-up was 5.1 years. Of these patients, 46 were node-negative, 59 were node-positive, and in 55 the pathological lymph node status was not known. Tumour sections were immunohistochemically stained with Factor VIII-related antibody. Microvessels were identified using previously recommended methodology and counted in three separate fields, selected from areas of highest vascularity, at x 200 magnification (field area = 0.785 mm2). Only the highest count was considered in the analysis. No association was found between microvessel density and age, menopausal status, tumour size, histological subtype, peritumoural vessel invasion, and lymph node involvement at presentation. There was no association between microvessel density and overall survival or relapse-free survival. These results suggest that microvessel density assessment, using currently recommended methods, is unlikely to be of prognostic value in ILC.
Affiliation:
Department of Histopathology, Christie Hospital, Manchester, U.K.
Citation:
Tumour angiogenesis as a prognostic marker in infiltrating lobular carcinoma of the breast. 1996, 180 (1):44-9 J. Pathol.
Journal:
Journal of Pathology
Issue Date:
Sep-1996
URI:
http://hdl.handle.net/10541/95174
DOI:
10.1002/(SICI)1096-9896(199609)180:1<44::AID-PATH648>3.0.CO;2-C
PubMed ID:
8943814
Type:
Article
Language:
en
ISSN:
0022-3417
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorMorphopoulos, Gen
dc.contributor.authorPearson, Men
dc.contributor.authorRyder, W David Jen
dc.contributor.authorHowell, Anthonyen
dc.contributor.authorHarris, Martinen
dc.date.accessioned2010-03-29T13:51:21Z-
dc.date.available2010-03-29T13:51:21Z-
dc.date.issued1996-09-
dc.identifier.citationTumour angiogenesis as a prognostic marker in infiltrating lobular carcinoma of the breast. 1996, 180 (1):44-9 J. Pathol.en
dc.identifier.issn0022-3417-
dc.identifier.pmid8943814-
dc.identifier.doi10.1002/(SICI)1096-9896(199609)180:1<44::AID-PATH648>3.0.CO;2-C-
dc.identifier.urihttp://hdl.handle.net/10541/95174-
dc.description.abstractThe importance of angiogenesis, assessed by tumour microvessel density, as a marker of survival was examined in 160 patients with infiltrating lobular carcinoma of the breast (ILC). The median follow-up was 5.1 years. Of these patients, 46 were node-negative, 59 were node-positive, and in 55 the pathological lymph node status was not known. Tumour sections were immunohistochemically stained with Factor VIII-related antibody. Microvessels were identified using previously recommended methodology and counted in three separate fields, selected from areas of highest vascularity, at x 200 magnification (field area = 0.785 mm2). Only the highest count was considered in the analysis. No association was found between microvessel density and age, menopausal status, tumour size, histological subtype, peritumoural vessel invasion, and lymph node involvement at presentation. There was no association between microvessel density and overall survival or relapse-free survival. These results suggest that microvessel density assessment, using currently recommended methods, is unlikely to be of prognostic value in ILC.en
dc.language.isoenen
dc.subjectBreast Canceren
dc.subjectCancer Invasivenessen
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshAged, 80 and over-
dc.subject.meshBreast Neoplasms-
dc.subject.meshCarcinoma, Lobular-
dc.subject.meshDisease-Free Survival-
dc.subject.meshFemale-
dc.subject.meshFollow-Up Studies-
dc.subject.meshHumans-
dc.subject.meshLymphatic Metastasis-
dc.subject.meshMiddle Aged-
dc.subject.meshNeoplasm Invasiveness-
dc.subject.meshNeovascularization, Pathologic-
dc.subject.meshPrognosis-
dc.subject.meshSurvival Rate-
dc.titleTumour angiogenesis as a prognostic marker in infiltrating lobular carcinoma of the breast.en
dc.typeArticleen
dc.contributor.departmentDepartment of Histopathology, Christie Hospital, Manchester, U.K.en
dc.identifier.journalJournal of Pathologyen

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