2.50
Hdl Handle:
http://hdl.handle.net/10541/94927
Title:
Structure-activity relationship of heparan sulphate.
Authors:
Gallagher, John T
Abstract:
HS influences fundamental cellular properties and biochemical processes at the cell surface. In addition to the issues already discussed, it has a profound effect on cell adhesion and migration through its interaction with many extracellular matrix proteins, most notably fibronectin and thrombospondin; it is closely linked to lipid metabolism through its capacity to bind low-density lipoprotein and lipoprotein lipase; and aberrations in HS structure and degradation are linked to human malignancy and Alzheimer's disease [26,27]. The subtle variations in HS structure enable it to distinguish between families of related proteins such as the FGFs, the chemokines [28] and the TGF beta s [29]. The multifunctional nature of HS is the result of its structural diversity and strategic positioning in the pericellular domain. The biosynthesis of HS, in common with other complex carbohydrates, is not directed by any known template yet the system is clearly subject to quite precise control so that in general, the HS family has a common domain organization that is finely tuned at the cellular level to produce HS species of variable length, fine structure and biological properties. A major challenge for future research will be to unravel the regulatory mechanisms that determine the molecular structure of HS. It remains unclear whether these mechanisms are entirely intrinsic in nature or subject to substantial modulation by the cellular microenvironment.
Affiliation:
Department of Medical Oncology, Paterson Institute for Cancer Research, Withington, Manchester, U.K.
Citation:
Structure-activity relationship of heparan sulphate. 1997, 25 (4):1206-9 Biochem. Soc. Trans.
Journal:
Biochemical Society Transactions
Issue Date:
Nov-1997
URI:
http://hdl.handle.net/10541/94927
PubMed ID:
9449976
Type:
Article
Language:
en
ISSN:
0300-5127
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorGallagher, John Ten
dc.date.accessioned2010-03-24T15:59:13Z-
dc.date.available2010-03-24T15:59:13Z-
dc.date.issued1997-11-
dc.identifier.citationStructure-activity relationship of heparan sulphate. 1997, 25 (4):1206-9 Biochem. Soc. Trans.en
dc.identifier.issn0300-5127-
dc.identifier.pmid9449976-
dc.identifier.urihttp://hdl.handle.net/10541/94927-
dc.description.abstractHS influences fundamental cellular properties and biochemical processes at the cell surface. In addition to the issues already discussed, it has a profound effect on cell adhesion and migration through its interaction with many extracellular matrix proteins, most notably fibronectin and thrombospondin; it is closely linked to lipid metabolism through its capacity to bind low-density lipoprotein and lipoprotein lipase; and aberrations in HS structure and degradation are linked to human malignancy and Alzheimer's disease [26,27]. The subtle variations in HS structure enable it to distinguish between families of related proteins such as the FGFs, the chemokines [28] and the TGF beta s [29]. The multifunctional nature of HS is the result of its structural diversity and strategic positioning in the pericellular domain. The biosynthesis of HS, in common with other complex carbohydrates, is not directed by any known template yet the system is clearly subject to quite precise control so that in general, the HS family has a common domain organization that is finely tuned at the cellular level to produce HS species of variable length, fine structure and biological properties. A major challenge for future research will be to unravel the regulatory mechanisms that determine the molecular structure of HS. It remains unclear whether these mechanisms are entirely intrinsic in nature or subject to substantial modulation by the cellular microenvironment.en
dc.language.isoenen
dc.subjectCanceren
dc.subject.meshAlzheimer Disease-
dc.subject.meshAnimals-
dc.subject.meshCarbohydrate Sequence-
dc.subject.meshChemokines-
dc.subject.meshHeparitin Sulfate-
dc.subject.meshHumans-
dc.subject.meshMolecular Sequence Data-
dc.subject.meshNeoplasms-
dc.subject.meshStructure-Activity Relationship-
dc.titleStructure-activity relationship of heparan sulphate.en
dc.typeArticleen
dc.contributor.departmentDepartment of Medical Oncology, Paterson Institute for Cancer Research, Withington, Manchester, U.K.en
dc.identifier.journalBiochemical Society Transactionsen
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