In vitro effects of recombinant human megakaryocyte growth and development factor on primary human tumour colony growth.

2.50
Hdl Handle:
http://hdl.handle.net/10541/94924
Title:
In vitro effects of recombinant human megakaryocyte growth and development factor on primary human tumour colony growth.
Authors:
Lang, Shona H; West, Catharine M L; Jones, L; Brooks, B; Kasper, C; De Wynter, Erika A; Testa, Nydia G
Abstract:
A study was made of the in vitro effects of recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) on breast, prostate, cervix and colon cancers. Tumour growth was assessed using a soft agar clonogenic assay. Stimulation of megakaryocyte numbers was seen in liquid culture following 10 ng/ml PEG-rHuMGDF. The same concentration led to no significant difference in colony-forming efficiencies for 22 of 25 tumour samples. A significant reduction in colony-forming efficiencies was seen for the remaining 3 specimens. These results suggest that PEG-rHuMGDF will not stimulate tumour growth in vivo.
Affiliation:
CRC Department of Experimental Haematology, Christie Hospital, Manchester, UK.
Citation:
In vitro effects of recombinant human megakaryocyte growth and development factor on primary human tumour colony growth., 54 (2):141-5 Oncology
Journal:
Oncology
Issue Date:
1997
URI:
http://hdl.handle.net/10541/94924
PubMed ID:
9075786
Type:
Article
Language:
en
ISSN:
0030-2414
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorLang, Shona Hen
dc.contributor.authorWest, Catharine M Len
dc.contributor.authorJones, Len
dc.contributor.authorBrooks, Ben
dc.contributor.authorKasper, Cen
dc.contributor.authorDe Wynter, Erika Aen
dc.contributor.authorTesta, Nydia Gen
dc.date.accessioned2010-03-24T15:40:32Z-
dc.date.available2010-03-24T15:40:32Z-
dc.date.issued1997-
dc.identifier.citationIn vitro effects of recombinant human megakaryocyte growth and development factor on primary human tumour colony growth., 54 (2):141-5 Oncologyen
dc.identifier.issn0030-2414-
dc.identifier.pmid9075786-
dc.identifier.urihttp://hdl.handle.net/10541/94924-
dc.description.abstractA study was made of the in vitro effects of recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) on breast, prostate, cervix and colon cancers. Tumour growth was assessed using a soft agar clonogenic assay. Stimulation of megakaryocyte numbers was seen in liquid culture following 10 ng/ml PEG-rHuMGDF. The same concentration led to no significant difference in colony-forming efficiencies for 22 of 25 tumour samples. A significant reduction in colony-forming efficiencies was seen for the remaining 3 specimens. These results suggest that PEG-rHuMGDF will not stimulate tumour growth in vivo.en
dc.language.isoenen
dc.subjectBreast Canceren
dc.subjectColonic Canceren
dc.subjectCanceren
dc.subjectProstatic Canceren
dc.subjectCultured Tumour Cellsen
dc.subjectUterine Cervical Canceren
dc.subject.meshBreast Neoplasms-
dc.subject.meshCell Division-
dc.subject.meshClone Cells-
dc.subject.meshColonic Neoplasms-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshMale-
dc.subject.meshMegakaryocytes-
dc.subject.meshNeoplasms-
dc.subject.meshPolyethylene Glycols-
dc.subject.meshProstatic Neoplasms-
dc.subject.meshRecombinant Proteins-
dc.subject.meshThrombopoietin-
dc.subject.meshTumor Cells, Cultured-
dc.subject.meshUterine Cervical Neoplasms-
dc.titleIn vitro effects of recombinant human megakaryocyte growth and development factor on primary human tumour colony growth.en
dc.typeArticleen
dc.contributor.departmentCRC Department of Experimental Haematology, Christie Hospital, Manchester, UK.en
dc.identifier.journalOncologyen
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