Continuous infusion of macrophage inflammatory protein MIP-1alpha enhances leucocyte recovery and haemopoietic progenitor cell mobilization after cyclophosphamide.

2.50
Hdl Handle:
http://hdl.handle.net/10541/94910
Title:
Continuous infusion of macrophage inflammatory protein MIP-1alpha enhances leucocyte recovery and haemopoietic progenitor cell mobilization after cyclophosphamide.
Authors:
Marshall, E; Woolford, Lorna B; Woolford, Lorna B; Woolford, Lorna B; Woolford, Lorna B; Woolford, Lorna B; Woolford, Lorna B; Woolford, Lorna B; Woolford, Lorna B; Woolford, Lorna B; Woolford, Lorna B; Woolford, Lorna B; Woolford, Lorna B; Woolford, Lorna B; Woolford, Lorna B; Woolford, Lorna B; Woolford, Lorna B; Woolford, Lorna B; Woolford, Lorna B; Woolford, Lorna B; Woolford, Lorna B; Lord, Brian I
Abstract:
Macrophage inflammatory protein 1alpha (MIP-1alpha) inhibits haemopoietic stem cell proliferation. This property has been exploited in a murine chemotherapy model and has been shown to ameliorate cytotoxic-induced myelosuppression after S-phase-specific cytotoxic therapy. We have now shown that BB-10010, a stable mutant of MIP-1alpha, (a) is more effective when administered as a continuous infusion than when bolus injected and (b), when administered via a 7-day infusion during and after cyclophosphamide treatment, results in an earlier recovery of leucocyte numbers. This effect was accompanied by progenitor cell mobilization into the peripheral blood and included primitive cells with marrow-repopulating ability (MRA). Maximal mobilization and recovery of leucocytes occurred when MIP-1alpha was combined with granulocyte colony-stimulating factor (G-CSF) therapy. The findings suggest that MIP1-alpha used alone or in combination with G-CSF may allow delivery of a greater chemotherapy dose intensity as a consequence of both accelerated leucocyte recovery and maintenance of high-quality mobilized progenitor cells for harvesting and peripheral blood stem cell transplantation.
Affiliation:
CRC Department of Medical Oncology, Christie Hospital, Manchester, UK.
Citation:
Continuous infusion of macrophage inflammatory protein MIP-1alpha enhances leucocyte recovery and haemopoietic progenitor cell mobilization after cyclophosphamide. 1997, 75 (12):1715-20 Br. J. Cancer
Journal:
British Journal of Cancer
Issue Date:
1997
URI:
http://hdl.handle.net/10541/94910
PubMed ID:
9192972
Type:
Article
Language:
en
ISSN:
0007-0920
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorMarshall, Een
dc.contributor.authorWoolford, Lorna Ben
dc.contributor.authorWoolford, Lorna Ben
dc.contributor.authorWoolford, Lorna Ben
dc.contributor.authorWoolford, Lorna Ben
dc.contributor.authorWoolford, Lorna Ben
dc.contributor.authorWoolford, Lorna Ben
dc.contributor.authorWoolford, Lorna Ben
dc.contributor.authorWoolford, Lorna Ben
dc.contributor.authorWoolford, Lorna Ben
dc.contributor.authorWoolford, Lorna Ben
dc.contributor.authorWoolford, Lorna Ben
dc.contributor.authorWoolford, Lorna Ben
dc.contributor.authorWoolford, Lorna Ben
dc.contributor.authorWoolford, Lorna Ben
dc.contributor.authorWoolford, Lorna Ben
dc.contributor.authorWoolford, Lorna Ben
dc.contributor.authorWoolford, Lorna Ben
dc.contributor.authorWoolford, Lorna Ben
dc.contributor.authorWoolford, Lorna Ben
dc.contributor.authorWoolford, Lorna Ben
dc.contributor.authorLord, Brian Ien
dc.date.accessioned2010-03-24T15:42:31Z-
dc.date.available2010-03-24T15:42:31Z-
dc.date.issued1997-
dc.identifier.citationContinuous infusion of macrophage inflammatory protein MIP-1alpha enhances leucocyte recovery and haemopoietic progenitor cell mobilization after cyclophosphamide. 1997, 75 (12):1715-20 Br. J. Canceren
dc.identifier.issn0007-0920-
dc.identifier.pmid9192972-
dc.identifier.urihttp://hdl.handle.net/10541/94910-
dc.description.abstractMacrophage inflammatory protein 1alpha (MIP-1alpha) inhibits haemopoietic stem cell proliferation. This property has been exploited in a murine chemotherapy model and has been shown to ameliorate cytotoxic-induced myelosuppression after S-phase-specific cytotoxic therapy. We have now shown that BB-10010, a stable mutant of MIP-1alpha, (a) is more effective when administered as a continuous infusion than when bolus injected and (b), when administered via a 7-day infusion during and after cyclophosphamide treatment, results in an earlier recovery of leucocyte numbers. This effect was accompanied by progenitor cell mobilization into the peripheral blood and included primitive cells with marrow-repopulating ability (MRA). Maximal mobilization and recovery of leucocytes occurred when MIP-1alpha was combined with granulocyte colony-stimulating factor (G-CSF) therapy. The findings suggest that MIP1-alpha used alone or in combination with G-CSF may allow delivery of a greater chemotherapy dose intensity as a consequence of both accelerated leucocyte recovery and maintenance of high-quality mobilized progenitor cells for harvesting and peripheral blood stem cell transplantation.en
dc.language.isoenen
dc.subjectHaematopoietic Stem Cell Transplantationen
dc.subjectHaematopoietic Stem Cellsen
dc.subject.meshAnimals-
dc.subject.meshAntineoplastic Agents, Alkylating-
dc.subject.meshBone Marrow-
dc.subject.meshChemokine CCL3-
dc.subject.meshChemokine CCL4-
dc.subject.meshColony-Forming Units Assay-
dc.subject.meshCyclophosphamide-
dc.subject.meshData Interpretation, Statistical-
dc.subject.meshDrug Therapy, Combination-
dc.subject.meshFemale-
dc.subject.meshGranulocyte Colony Stimulating Factor, Recombinant-
dc.subject.meshHematopoietic Stem Cell Transplantation-
dc.subject.meshHematopoietic Stem Cells-
dc.subject.meshInfusions, Parenteral-
dc.subject.meshLeukocyte Count-
dc.subject.meshLeukocytes-
dc.subject.meshMacrophage Inflammatory Proteins-
dc.subject.meshMale-
dc.subject.meshMice-
dc.subject.meshMice, Inbred C57BL-
dc.subject.meshMice, Inbred DBA-
dc.subject.meshRadiation Dosage-
dc.subject.meshTime Factors-
dc.titleContinuous infusion of macrophage inflammatory protein MIP-1alpha enhances leucocyte recovery and haemopoietic progenitor cell mobilization after cyclophosphamide.en
dc.typeArticleen
dc.contributor.departmentCRC Department of Medical Oncology, Christie Hospital, Manchester, UK.en
dc.identifier.journalBritish Journal of Canceren
All Items in Christie are protected by copyright, with all rights reserved, unless otherwise indicated.