Comparative genomic hybridisation of ductal carcinoma in situ of the breast: identification of regions of DNA amplification and deletion in common with invasive breast carcinoma.

2.50
Hdl Handle:
http://hdl.handle.net/10541/94907
Title:
Comparative genomic hybridisation of ductal carcinoma in situ of the breast: identification of regions of DNA amplification and deletion in common with invasive breast carcinoma.
Authors:
James, Louise A; Mitchell, Erika L D; Menasce, Lia P; Varley, Jennifer
Abstract:
Comparative genomic hybridisation has been used to map copy number changes in nine cases of ductal carcinoma in situ of the breast obtained from wax-embedded archive material. A wide variety of abnormalities were detected including gain of regions of 1q, 17q, 19q, 20p and 20q and loss on 13q, 14q, 17p, 16q and 22q. Amplification of areas on 10p, 8q and 20q were also observed. Chromosomal alterations were more frequent in higher grade DCIS and closely resemble those previously detected in invasive breast cancer using the same technique. These data provide strong molecular support for the view that DCIS is a precursor lesion of invasive breast carcinoma.
Affiliation:
CRC Department of Cancer Genetics, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester.
Citation:
Comparative genomic hybridisation of ductal carcinoma in situ of the breast: identification of regions of DNA amplification and deletion in common with invasive breast carcinoma. 1997, 14 (9):1059-65 Oncogene
Journal:
Oncogene
Issue Date:
6-Mar-1997
URI:
http://hdl.handle.net/10541/94907
DOI:
10.1038/sj.onc.1200923
PubMed ID:
9070654
Type:
Article
Language:
en
ISSN:
0950-9232
Appears in Collections:
All Christie Publications ; All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorJames, Louise Aen
dc.contributor.authorMitchell, Erika L Den
dc.contributor.authorMenasce, Lia Pen
dc.contributor.authorVarley, Jenniferen
dc.date.accessioned2010-03-24T15:29:09Z-
dc.date.available2010-03-24T15:29:09Z-
dc.date.issued1997-03-06-
dc.identifier.citationComparative genomic hybridisation of ductal carcinoma in situ of the breast: identification of regions of DNA amplification and deletion in common with invasive breast carcinoma. 1997, 14 (9):1059-65 Oncogeneen
dc.identifier.issn0950-9232-
dc.identifier.pmid9070654-
dc.identifier.doi10.1038/sj.onc.1200923-
dc.identifier.urihttp://hdl.handle.net/10541/94907-
dc.description.abstractComparative genomic hybridisation has been used to map copy number changes in nine cases of ductal carcinoma in situ of the breast obtained from wax-embedded archive material. A wide variety of abnormalities were detected including gain of regions of 1q, 17q, 19q, 20p and 20q and loss on 13q, 14q, 17p, 16q and 22q. Amplification of areas on 10p, 8q and 20q were also observed. Chromosomal alterations were more frequent in higher grade DCIS and closely resemble those previously detected in invasive breast cancer using the same technique. These data provide strong molecular support for the view that DCIS is a precursor lesion of invasive breast carcinoma.en
dc.language.isoenen
dc.subjectBreast Canceren
dc.subject.meshAged-
dc.subject.meshBreast Neoplasms-
dc.subject.meshCarcinoma in Situ-
dc.subject.meshCarcinoma, Ductal, Breast-
dc.subject.meshFemale-
dc.subject.meshGene Amplification-
dc.subject.meshGene Deletion-
dc.subject.meshHumans-
dc.subject.meshMiddle Aged-
dc.subject.meshNucleic Acid Hybridization-
dc.subject.meshRetrospective Studies-
dc.titleComparative genomic hybridisation of ductal carcinoma in situ of the breast: identification of regions of DNA amplification and deletion in common with invasive breast carcinoma.en
dc.typeArticleen
dc.contributor.departmentCRC Department of Cancer Genetics, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester.en
dc.identifier.journalOncogeneen

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