Adenomyoepithelioma of the skin: a case report with immunohistochemical and ultrastructural observations.

2.50
Hdl Handle:
http://hdl.handle.net/10541/94850
Title:
Adenomyoepithelioma of the skin: a case report with immunohistochemical and ultrastructural observations.
Authors:
Wallis, N T; Banerjee, Saumitra S; Eyden, Brian P; Armstrong, G
Abstract:
AIMS: The histological, immunohistochemical and electron microscopic features of a primary adenomyoepithelioma of skin, a rare sweat gland tumour, are reported. METHODS AND RESULTS: The tumour occurred on the back of a 92-year-old woman. It was composed of well-formed tubules lined by epithelial cells surrounded by clear or spindled myoepithelial cells. Immunohistochemically, the epithelial cells exhibited strong cytokeratin (CAM5.2) and weak carcinoembryonic antigen positivity. The myoepithelial cells showed diffuse positivity for smooth muscle actin and focal positivity for S100 protein. Ultrastructurally, the myoepithelial cells contained myofilaments with focal densities and hemidesmosomes. They were limited by well-formed basal lamina. The tumour was associated with a small eccrine spiradenoma. CONCLUSION: We predict that the tumour will behave in a benign fashion. There is no evidence of recurrence or metastasis 28 months later.
Affiliation:
Department of Histopathology, Christie Hospital NHS Trust, Manchester, UK.
Citation:
Adenomyoepithelioma of the skin: a case report with immunohistochemical and ultrastructural observations. 1997, 31 (4):374-7 Histopathology
Journal:
Histopathology
Issue Date:
Oct-1997
URI:
http://hdl.handle.net/10541/94850
DOI:
10.1046/j.1365-2559.1997.2700863.x
PubMed ID:
9363454
Type:
Article
Language:
en
ISSN:
0309-0167
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorWallis, N Ten
dc.contributor.authorBanerjee, Saumitra Sen
dc.contributor.authorEyden, Brian Pen
dc.contributor.authorArmstrong, Gen
dc.date.accessioned2010-03-24T14:06:31Z-
dc.date.available2010-03-24T14:06:31Z-
dc.date.issued1997-10-
dc.identifier.citationAdenomyoepithelioma of the skin: a case report with immunohistochemical and ultrastructural observations. 1997, 31 (4):374-7 Histopathologyen
dc.identifier.issn0309-0167-
dc.identifier.pmid9363454-
dc.identifier.doi10.1046/j.1365-2559.1997.2700863.x-
dc.identifier.urihttp://hdl.handle.net/10541/94850-
dc.description.abstractAIMS: The histological, immunohistochemical and electron microscopic features of a primary adenomyoepithelioma of skin, a rare sweat gland tumour, are reported. METHODS AND RESULTS: The tumour occurred on the back of a 92-year-old woman. It was composed of well-formed tubules lined by epithelial cells surrounded by clear or spindled myoepithelial cells. Immunohistochemically, the epithelial cells exhibited strong cytokeratin (CAM5.2) and weak carcinoembryonic antigen positivity. The myoepithelial cells showed diffuse positivity for smooth muscle actin and focal positivity for S100 protein. Ultrastructurally, the myoepithelial cells contained myofilaments with focal densities and hemidesmosomes. They were limited by well-formed basal lamina. The tumour was associated with a small eccrine spiradenoma. CONCLUSION: We predict that the tumour will behave in a benign fashion. There is no evidence of recurrence or metastasis 28 months later.en
dc.language.isoenen
dc.subjectSweat Gland Canceren
dc.subject.meshActins-
dc.subject.meshAdenomyoma-
dc.subject.meshAged-
dc.subject.meshAged, 80 and over-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshImmunohistochemistry-
dc.subject.meshMicroscopy, Electron-
dc.subject.meshMyoepithelioma-
dc.subject.meshSweat Gland Neoplasms-
dc.titleAdenomyoepithelioma of the skin: a case report with immunohistochemical and ultrastructural observations.en
dc.typeArticleen
dc.contributor.departmentDepartment of Histopathology, Christie Hospital NHS Trust, Manchester, UK.en
dc.identifier.journalHistopathologyen

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