Myofibrosarcoma of the breast: review of the literature on myofibroblastic tumors and criteria for defining myofibroblastic differentiation.

2.50
Hdl Handle:
http://hdl.handle.net/10541/94795
Title:
Myofibrosarcoma of the breast: review of the literature on myofibroblastic tumors and criteria for defining myofibroblastic differentiation.
Authors:
Taccagni, G; Rovere, E; Masullo, M; Christensen, L; Eyden, Brian P
Abstract:
A case of myofibrosarcoma of the breast is described. A 55-year-old woman presented with a small mammary nodule. A large recurrent lesions appeared a month later, and the patient died 11 months following initial presentation from diffuse pleuropulmonary metastases. Histologically, the primary tumor consisted mainly of spindled cells, arranged in fascicles and surrounded by varying quantities of dense hyaline collagen. The recurrent lesion had a more pleomorphic organization. In both lesions, there was positive immunostaining for vimentin, smooth-muscle actin, and fibronectin, and negative results for desmin, laminin, and type IV collagen. Electron microscopy revealed abundant rough endoplasmic reticulum, myofilaments with focal densities, and the fibronexus junctions and fibronectin fibrils characteristic of myofibroblasts. Given these cellular features and behavior, the tumor was interpreted as a malignant neoplasm showing myofibroblastic differentiation, i.e., a myofibrosarcoma. This case enlarges the group of myofibrosarcoma of breast, also with the demonstration of fibronexus and fibronectin fibrils. The paper emphasizes the criteria required for myofibroblastic differentiation and reviews lesions of the breast reported in the literature as myofibroblastic.
Affiliation:
Department of Pathology, Scientific Institute H San Raffaele, Milano, Italy.
Citation:
Myofibrosarcoma of the breast: review of the literature on myofibroblastic tumors and criteria for defining myofibroblastic differentiation. 1997, 21 (4):489-96 Am. J. Surg. Pathol.
Journal:
The American Journal of Surgical Pathology
Issue Date:
Apr-1997
URI:
http://hdl.handle.net/10541/94795
PubMed ID:
9130998
Type:
Article
Language:
en
ISSN:
0147-5185
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorTaccagni, Gen
dc.contributor.authorRovere, Een
dc.contributor.authorMasullo, Men
dc.contributor.authorChristensen, Len
dc.contributor.authorEyden, Brian Pen
dc.date.accessioned2010-03-24T10:09:44Z-
dc.date.available2010-03-24T10:09:44Z-
dc.date.issued1997-04-
dc.identifier.citationMyofibrosarcoma of the breast: review of the literature on myofibroblastic tumors and criteria for defining myofibroblastic differentiation. 1997, 21 (4):489-96 Am. J. Surg. Pathol.en
dc.identifier.issn0147-5185-
dc.identifier.pmid9130998-
dc.identifier.urihttp://hdl.handle.net/10541/94795-
dc.description.abstractA case of myofibrosarcoma of the breast is described. A 55-year-old woman presented with a small mammary nodule. A large recurrent lesions appeared a month later, and the patient died 11 months following initial presentation from diffuse pleuropulmonary metastases. Histologically, the primary tumor consisted mainly of spindled cells, arranged in fascicles and surrounded by varying quantities of dense hyaline collagen. The recurrent lesion had a more pleomorphic organization. In both lesions, there was positive immunostaining for vimentin, smooth-muscle actin, and fibronectin, and negative results for desmin, laminin, and type IV collagen. Electron microscopy revealed abundant rough endoplasmic reticulum, myofilaments with focal densities, and the fibronexus junctions and fibronectin fibrils characteristic of myofibroblasts. Given these cellular features and behavior, the tumor was interpreted as a malignant neoplasm showing myofibroblastic differentiation, i.e., a myofibrosarcoma. This case enlarges the group of myofibrosarcoma of breast, also with the demonstration of fibronexus and fibronectin fibrils. The paper emphasizes the criteria required for myofibroblastic differentiation and reviews lesions of the breast reported in the literature as myofibroblastic.en
dc.language.isoenen
dc.subjectBreast Canceren
dc.subjectMuscle Tissue Canceren
dc.subject.meshBreast Neoplasms-
dc.subject.meshCell Differentiation-
dc.subject.meshFemale-
dc.subject.meshFibroblasts-
dc.subject.meshFibrosarcoma-
dc.subject.meshHumans-
dc.subject.meshImmunohistochemistry-
dc.subject.meshMiddle Aged-
dc.subject.meshNeoplasms, Muscle Tissue-
dc.titleMyofibrosarcoma of the breast: review of the literature on myofibroblastic tumors and criteria for defining myofibroblastic differentiation.en
dc.typeArticleen
dc.contributor.departmentDepartment of Pathology, Scientific Institute H San Raffaele, Milano, Italy.en
dc.identifier.journalThe American Journal of Surgical Pathologyen

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