Analysis of chromosome 6 deletions in lymphoid malignancies provides evidence for a region of minimal deletion within a 2-megabase segment of 6q21.

2.50
Hdl Handle:
http://hdl.handle.net/10541/94775
Title:
Analysis of chromosome 6 deletions in lymphoid malignancies provides evidence for a region of minimal deletion within a 2-megabase segment of 6q21.
Authors:
Sherratt, T; Morelli, C; Boyle, John M; Harrison, Christine J
Abstract:
Fluorescence in situ hybridization has been used to define deletion breakpoints within chromosome bands 6q16-21 in cases of lymphoid malignancy. Previous evidence suggested that the region might contain a tumour-suppressor gene. Six yeast artificial chromosome probes, each selected using a single marker, were localized to 6q16-21 and the following order was confirmed; D6S330-D6S283-D6S301-D6S447-D6S246-FYN+ ++. Of 32 cases of lymphoid malignancy, 30 showed deletion of D6S246 and, in the two cases in which D6S246 was retained, the adjacent marker, D6S447, was deleted. These observations imply that a region of minimal deletion is located within a 2-megabase segment of 6q21, between D6S447 and D6S246, providing a candidate region for the location of a tumour-suppressor gene.
Affiliation:
Department of Cancer Genetics, Paterson Institute for Cancer Research, Manchester, UK.
Citation:
Analysis of chromosome 6 deletions in lymphoid malignancies provides evidence for a region of minimal deletion within a 2-megabase segment of 6q21. 1997, 5 (2):118-24 Chromosome Res.
Journal:
Chromosome Research
Issue Date:
Apr-1997
URI:
http://hdl.handle.net/10541/94775
DOI:
10.1023/A:1018418224660
PubMed ID:
9146915
Type:
Article
Language:
en
ISSN:
0967-3849
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorSherratt, Ten
dc.contributor.authorMorelli, Cen
dc.contributor.authorBoyle, John Men
dc.contributor.authorHarrison, Christine Jen
dc.date.accessioned2010-03-23T17:12:59Z-
dc.date.available2010-03-23T17:12:59Z-
dc.date.issued1997-04-
dc.identifier.citationAnalysis of chromosome 6 deletions in lymphoid malignancies provides evidence for a region of minimal deletion within a 2-megabase segment of 6q21. 1997, 5 (2):118-24 Chromosome Res.en
dc.identifier.issn0967-3849-
dc.identifier.pmid9146915-
dc.identifier.doi10.1023/A:1018418224660-
dc.identifier.urihttp://hdl.handle.net/10541/94775-
dc.description.abstractFluorescence in situ hybridization has been used to define deletion breakpoints within chromosome bands 6q16-21 in cases of lymphoid malignancy. Previous evidence suggested that the region might contain a tumour-suppressor gene. Six yeast artificial chromosome probes, each selected using a single marker, were localized to 6q16-21 and the following order was confirmed; D6S330-D6S283-D6S301-D6S447-D6S246-FYN+ ++. Of 32 cases of lymphoid malignancy, 30 showed deletion of D6S246 and, in the two cases in which D6S246 was retained, the adjacent marker, D6S447, was deleted. These observations imply that a region of minimal deletion is located within a 2-megabase segment of 6q21, between D6S447 and D6S246, providing a candidate region for the location of a tumour-suppressor gene.en
dc.language.isoenen
dc.subjectPrecursor Cell Lymphoblastic Leukaemia-Lymphomaen
dc.subjectTumour Suppressor Genesen
dc.subjectBiological Tumour Markersen
dc.subject.meshChromosome Deletion-
dc.subject.meshChromosome Mapping-
dc.subject.meshChromosomes, Artificial, Yeast-
dc.subject.meshChromosomes, Human, Pair 6-
dc.subject.meshDNA Probes-
dc.subject.meshGenes, Tumor Suppressor-
dc.subject.meshHumans-
dc.subject.meshIn Situ Hybridization, Fluorescence-
dc.subject.meshKaryotyping-
dc.subject.meshLymphoma, Non-Hodgkin-
dc.subject.meshPrecursor Cell Lymphoblastic Leukemia-Lymphoma-
dc.subject.meshSequence Tagged Sites-
dc.subject.meshTumor Markers, Biological-
dc.titleAnalysis of chromosome 6 deletions in lymphoid malignancies provides evidence for a region of minimal deletion within a 2-megabase segment of 6q21.en
dc.typeArticleen
dc.contributor.departmentDepartment of Cancer Genetics, Paterson Institute for Cancer Research, Manchester, UK.en
dc.identifier.journalChromosome Researchen

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