Apolipoprotein E genotypes and serum lipid levels in Alzheimer's disease and multi-infarct dementia.

2.50
Hdl Handle:
http://hdl.handle.net/10541/94734
Title:
Apolipoprotein E genotypes and serum lipid levels in Alzheimer's disease and multi-infarct dementia.
Authors:
Wieringa, Gilbert E; Burlinson, S; Rafferty, Joseph A; Gowland, E; Burns, A
Abstract:
OBJECTIVE: Assessment of apolipoprotein E genotype, serum cholesterol, triglycerides, high density lipoprotein-cholesterol and low density lipoprotein-cholesterol levels in different types of dementia. SUBJECTS: 102 consecutive referrals to an old age psychiatry service based at Manchester were classified according to clinical criteria based on ICD 10. RESULTS: Thirty-seven were considered to have Alzheimer's disease, 16 multi-infarct dementia and 33 to be free from dementia. Sixteen patients, in whom a definitive diagnosis could not be reached or sufficient information was not available, were excluded from the study. There was an increase in the prevalence of the Apo E4 allele in both Alzheimer's disease (chi 2 = 3.82, p < 0.05) and multi-infarct dementia (chi 2 = 1.93, p < 0. = 0.16) by Wald tests compared to individuals without dementia. The increased prevalence of the E4 Allele in multi-infarct dementia was not related to serum lipid levels. CONCLUSION: The hypothesis that the onset of multi-infarct dementia may be precipitated by E4's mediation of higher serum cholesterol levels is not supported by the present study.
Affiliation:
Department of Biochemistry, Christie Hospital NHS Trust, Manchester, UK.
Citation:
Apolipoprotein E genotypes and serum lipid levels in Alzheimer's disease and multi-infarct dementia. 1997, 12 (3):359-62 Int J Geriatr Psychiatry
Journal:
International Journal of Geriatric Psychiatry
Issue Date:
Mar-1997
URI:
http://hdl.handle.net/10541/94734
PubMed ID:
9152721
Type:
Article
Language:
en
ISSN:
0885-6230
Appears in Collections:
All Christie Publications ; All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorWieringa, Gilbert Een
dc.contributor.authorBurlinson, Sen
dc.contributor.authorRafferty, Joseph Aen
dc.contributor.authorGowland, Een
dc.contributor.authorBurns, Aen
dc.date.accessioned2010-03-23T16:22:16Z-
dc.date.available2010-03-23T16:22:16Z-
dc.date.issued1997-03-
dc.identifier.citationApolipoprotein E genotypes and serum lipid levels in Alzheimer's disease and multi-infarct dementia. 1997, 12 (3):359-62 Int J Geriatr Psychiatryen
dc.identifier.issn0885-6230-
dc.identifier.pmid9152721-
dc.identifier.urihttp://hdl.handle.net/10541/94734-
dc.description.abstractOBJECTIVE: Assessment of apolipoprotein E genotype, serum cholesterol, triglycerides, high density lipoprotein-cholesterol and low density lipoprotein-cholesterol levels in different types of dementia. SUBJECTS: 102 consecutive referrals to an old age psychiatry service based at Manchester were classified according to clinical criteria based on ICD 10. RESULTS: Thirty-seven were considered to have Alzheimer's disease, 16 multi-infarct dementia and 33 to be free from dementia. Sixteen patients, in whom a definitive diagnosis could not be reached or sufficient information was not available, were excluded from the study. There was an increase in the prevalence of the Apo E4 allele in both Alzheimer's disease (chi 2 = 3.82, p < 0.05) and multi-infarct dementia (chi 2 = 1.93, p < 0. = 0.16) by Wald tests compared to individuals without dementia. The increased prevalence of the E4 Allele in multi-infarct dementia was not related to serum lipid levels. CONCLUSION: The hypothesis that the onset of multi-infarct dementia may be precipitated by E4's mediation of higher serum cholesterol levels is not supported by the present study.en
dc.language.isoenen
dc.subject.meshAged-
dc.subject.meshAged, 80 and over-
dc.subject.meshAlleles-
dc.subject.meshAlzheimer Disease-
dc.subject.meshApolipoprotein E4-
dc.subject.meshApolipoproteins E-
dc.subject.meshCholesterol-
dc.subject.meshCholesterol, HDL-
dc.subject.meshCholesterol, LDL-
dc.subject.meshDementia, Multi-Infarct-
dc.subject.meshGenotype-
dc.subject.meshHumans-
dc.subject.meshLipids-
dc.subject.meshMiddle Aged-
dc.subject.meshTriglycerides-
dc.titleApolipoprotein E genotypes and serum lipid levels in Alzheimer's disease and multi-infarct dementia.en
dc.typeArticleen
dc.contributor.departmentDepartment of Biochemistry, Christie Hospital NHS Trust, Manchester, UK.en
dc.identifier.journalInternational Journal of Geriatric Psychiatryen

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