Nodular erythema elevatum diutinum mimicking cutaneous neoplasms.

2.50
Hdl Handle:
http://hdl.handle.net/10541/94723
Title:
Nodular erythema elevatum diutinum mimicking cutaneous neoplasms.
Authors:
Shanks, Jonathan H; Banerjee, Saumitra S; Bishop, P W; Pearson, J M; Eyden, Brian P
Abstract:
AIMS: We describe the cutaneous pseudoneoplastic lesions in two patients with nodular erythema elevatum diutinum, a rare chronic disorder in which polymorph nuclear fragmentation (leukocytoclasis) is present within dermal nodules showing spindle cells and fibrosis. In both cases diagnostic difficulty was encountered clinically and pathologically and various benign and malignant neoplasms were considered in the differential diagnosis. METHODS AND RESULTS: Immunohistochemically the spindle cells were negative for CAM5.2, AE1/3, S100 protein and desmin (D33). They were positive for vimentin and focally positive for CD34 and alpha-smooth muscle actin. Some of the spindle cells were positive for Mac 387 and KP1(CD68). By electron microscopy, the lesions were shown to consist of fibroblasts/myofibroblasts and fusiform macrophages. CONCLUSIONS: Increased awareness of the features described will help to avoid misdiagnosis as a neoplastic process.
Affiliation:
Department of Histopathology, Christie Hospital NHS Trust, UK.
Citation:
Nodular erythema elevatum diutinum mimicking cutaneous neoplasms. 1997, 31 (1):91-6 Histopathology
Journal:
Histopathology
Issue Date:
Jul-1997
URI:
http://hdl.handle.net/10541/94723
DOI:
10.1046/j.1365-2559.1997.5840815.x
PubMed ID:
9253631
Type:
Article
Language:
en
ISSN:
0309-0167
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorShanks, Jonathan Hen
dc.contributor.authorBanerjee, Saumitra Sen
dc.contributor.authorBishop, P Wen
dc.contributor.authorPearson, J Men
dc.contributor.authorEyden, Brian Pen
dc.date.accessioned2010-03-23T16:04:02Z-
dc.date.available2010-03-23T16:04:02Z-
dc.date.issued1997-07-
dc.identifier.citationNodular erythema elevatum diutinum mimicking cutaneous neoplasms. 1997, 31 (1):91-6 Histopathologyen
dc.identifier.issn0309-0167-
dc.identifier.pmid9253631-
dc.identifier.doi10.1046/j.1365-2559.1997.5840815.x-
dc.identifier.urihttp://hdl.handle.net/10541/94723-
dc.description.abstractAIMS: We describe the cutaneous pseudoneoplastic lesions in two patients with nodular erythema elevatum diutinum, a rare chronic disorder in which polymorph nuclear fragmentation (leukocytoclasis) is present within dermal nodules showing spindle cells and fibrosis. In both cases diagnostic difficulty was encountered clinically and pathologically and various benign and malignant neoplasms were considered in the differential diagnosis. METHODS AND RESULTS: Immunohistochemically the spindle cells were negative for CAM5.2, AE1/3, S100 protein and desmin (D33). They were positive for vimentin and focally positive for CD34 and alpha-smooth muscle actin. Some of the spindle cells were positive for Mac 387 and KP1(CD68). By electron microscopy, the lesions were shown to consist of fibroblasts/myofibroblasts and fusiform macrophages. CONCLUSIONS: Increased awareness of the features described will help to avoid misdiagnosis as a neoplastic process.en
dc.language.isoenen
dc.subjectSkin Canceren
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshDiagnosis, Differential-
dc.subject.meshErythema Induratum-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshMale-
dc.subject.meshSkin Diseases-
dc.subject.meshSkin Neoplasms-
dc.titleNodular erythema elevatum diutinum mimicking cutaneous neoplasms.en
dc.typeArticleen
dc.contributor.departmentDepartment of Histopathology, Christie Hospital NHS Trust, UK.en
dc.identifier.journalHistopathologyen

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