Incidence of hereditary non-polyposis colorectal cancer in a population-based study of 1137 consecutive cases of colorectal cancer.

2.50
Hdl Handle:
http://hdl.handle.net/10541/94678
Title:
Incidence of hereditary non-polyposis colorectal cancer in a population-based study of 1137 consecutive cases of colorectal cancer.
Authors:
Evans, D Gareth R; Walsh, S; Jeacock, J; Robinson, C; Hadfield, L; Davies, D R; Kingston, R
Abstract:
BACKGROUND: Previous reports have indicated that 5-13 per cent of colorectal cancer is hereditary. However, the proportion of cases arising as a result of mutations in the hereditary non-polyposis colorectal cancer (HNPCC) genes remains to be determined. METHODS: This study is a part prospective, part retrospective review of all cases of colorectal cancer from a district hospital over 14 years. Some 1137 consecutive patients with colorectal cancer were questioned about their family history of cancer and details were logged on a database. For the past 4 years each case has been re-evaluated where possible. RESULTS: Some 118 patients indicated initially that they had a first-degree relative with colorectal cancer, but on re-evaluation there were significant discrepancies. Only three cases (0.3 per cent) occurred in families which strictly fulfilled the criteria for HNPCC and there were no cases of familial adenomatous polyposis. A total of 16 patients (1.4 per cent) fulfilled looser criteria for HNPCC. CONCLUSION: This population-based study has shown a lower frequency of familial bowel cancer than previous studies and may reflect a lower incidence of inherited mutations in the HNPCC DNA mismatch repair genes than is currently accepted.
Affiliation:
Department of Medical Genetics, St Mary's Hospital, Manchester, UK.
Citation:
Incidence of hereditary non-polyposis colorectal cancer in a population-based study of 1137 consecutive cases of colorectal cancer. 1997, 84 (9):1281-5 Br J Surg
Journal:
British Journal of Surgery
Issue Date:
Sep-1997
URI:
http://hdl.handle.net/10541/94678
DOI:
10.1046/j.1365-2168.1997.02781.x
PubMed ID:
9313714
Type:
Article
Language:
en
ISSN:
0007-1323
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorEvans, D Gareth Ren
dc.contributor.authorWalsh, Sen
dc.contributor.authorJeacock, Jen
dc.contributor.authorRobinson, Cen
dc.contributor.authorHadfield, Len
dc.contributor.authorDavies, D Ren
dc.contributor.authorKingston, Ren
dc.date.accessioned2010-03-23T12:09:57Z-
dc.date.available2010-03-23T12:09:57Z-
dc.date.issued1997-09-
dc.identifier.citationIncidence of hereditary non-polyposis colorectal cancer in a population-based study of 1137 consecutive cases of colorectal cancer. 1997, 84 (9):1281-5 Br J Surgen
dc.identifier.issn0007-1323-
dc.identifier.pmid9313714-
dc.identifier.doi10.1046/j.1365-2168.1997.02781.x-
dc.identifier.urihttp://hdl.handle.net/10541/94678-
dc.description.abstractBACKGROUND: Previous reports have indicated that 5-13 per cent of colorectal cancer is hereditary. However, the proportion of cases arising as a result of mutations in the hereditary non-polyposis colorectal cancer (HNPCC) genes remains to be determined. METHODS: This study is a part prospective, part retrospective review of all cases of colorectal cancer from a district hospital over 14 years. Some 1137 consecutive patients with colorectal cancer were questioned about their family history of cancer and details were logged on a database. For the past 4 years each case has been re-evaluated where possible. RESULTS: Some 118 patients indicated initially that they had a first-degree relative with colorectal cancer, but on re-evaluation there were significant discrepancies. Only three cases (0.3 per cent) occurred in families which strictly fulfilled the criteria for HNPCC and there were no cases of familial adenomatous polyposis. A total of 16 patients (1.4 per cent) fulfilled looser criteria for HNPCC. CONCLUSION: This population-based study has shown a lower frequency of familial bowel cancer than previous studies and may reflect a lower incidence of inherited mutations in the HNPCC DNA mismatch repair genes than is currently accepted.en
dc.language.isoenen
dc.subjectColorectal Canceren
dc.subject.meshAdult-
dc.subject.meshAge of Onset-
dc.subject.meshAged-
dc.subject.meshAged, 80 and over-
dc.subject.meshColorectal Neoplasms, Hereditary Nonpolyposis-
dc.subject.meshDisease Susceptibility-
dc.subject.meshEngland-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshIncidence-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshPedigree-
dc.subject.meshProspective Studies-
dc.subject.meshRetrospective Studies-
dc.titleIncidence of hereditary non-polyposis colorectal cancer in a population-based study of 1137 consecutive cases of colorectal cancer.en
dc.typeArticleen
dc.contributor.departmentDepartment of Medical Genetics, St Mary's Hospital, Manchester, UK.en
dc.identifier.journalBritish Journal of Surgeryen

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