Experience of external beam radiotherapy given adjuvantly or at relapse following surgery for craniopharyngioma.

2.50
Hdl Handle:
http://hdl.handle.net/10541/94301
Title:
Experience of external beam radiotherapy given adjuvantly or at relapse following surgery for craniopharyngioma.
Authors:
Pemberton, Laura S; Dougal, Mark; Magee, Brian; Gattamaneni, Rao
Abstract:
BACKGROUND AND PURPOSE: Evaluation of effect of timing of external beam radiation therapy (EBRT) following surgery for craniopharyngioma. MATERIALS AND METHODS: Between 1976 and 2002, 87 patients (28 children) received EBRT in a regional referral centre. Forty-four patients received EBRT adjuvantly and 43 on relapse. The median total dose was 42.5Gy (range 34.7-52.5Gy) in 2.25-2.83Gy fractions over a median of 20 days (range 17-32). Effect of EBRT timing, type of original surgery, age on survival, progression-free survival (PFS) and quality of life (QOL) was studied. RESULTS: Survival from diagnosis was 86 and 76% and PFS was 78 and 66% at 10 and 20 years, respectively, with no significant difference seen between those treated adjuvantly or at relapse or according to age. QOL deteriorated significantly from diagnosis to last follow-up. Excluding patients who relapsed following EBRT, QOL did not deteriorate significantly overall (P=0.35). Children had worse QOL and greater morbidity at all timepoints compared to adults. CONCLUSIONS: EBRT is effective both adjuvantly and at relapse. QOL deteriorates over time-relapse following EBRT was the only significant factor. Children have greater morbidity compared to adults, but no evidence for greater EBRT-induced toxicity was seen.
Affiliation:
Department of Clinical Oncology, Christie Hospital, Withington, UK.
Citation:
Experience of external beam radiotherapy given adjuvantly or at relapse following surgery for craniopharyngioma. 2005, 77 (1):99-104 Radiother Oncol
Journal:
Radiotherapy and Oncology
Issue Date:
Oct-2005
URI:
http://hdl.handle.net/10541/94301
DOI:
10.1016/j.radonc.2005.04.015
PubMed ID:
16216361
Type:
Article
Language:
en
ISSN:
0167-8140
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorPemberton, Laura Sen
dc.contributor.authorDougal, Marken
dc.contributor.authorMagee, Brianen
dc.contributor.authorGattamaneni, Raoen
dc.date.accessioned2010-03-15T17:01:57Z-
dc.date.available2010-03-15T17:01:57Z-
dc.date.issued2005-10-
dc.identifier.citationExperience of external beam radiotherapy given adjuvantly or at relapse following surgery for craniopharyngioma. 2005, 77 (1):99-104 Radiother Oncolen
dc.identifier.issn0167-8140-
dc.identifier.pmid16216361-
dc.identifier.doi10.1016/j.radonc.2005.04.015-
dc.identifier.urihttp://hdl.handle.net/10541/94301-
dc.description.abstractBACKGROUND AND PURPOSE: Evaluation of effect of timing of external beam radiation therapy (EBRT) following surgery for craniopharyngioma. MATERIALS AND METHODS: Between 1976 and 2002, 87 patients (28 children) received EBRT in a regional referral centre. Forty-four patients received EBRT adjuvantly and 43 on relapse. The median total dose was 42.5Gy (range 34.7-52.5Gy) in 2.25-2.83Gy fractions over a median of 20 days (range 17-32). Effect of EBRT timing, type of original surgery, age on survival, progression-free survival (PFS) and quality of life (QOL) was studied. RESULTS: Survival from diagnosis was 86 and 76% and PFS was 78 and 66% at 10 and 20 years, respectively, with no significant difference seen between those treated adjuvantly or at relapse or according to age. QOL deteriorated significantly from diagnosis to last follow-up. Excluding patients who relapsed following EBRT, QOL did not deteriorate significantly overall (P=0.35). Children had worse QOL and greater morbidity at all timepoints compared to adults. CONCLUSIONS: EBRT is effective both adjuvantly and at relapse. QOL deteriorates over time-relapse following EBRT was the only significant factor. Children have greater morbidity compared to adults, but no evidence for greater EBRT-induced toxicity was seen.en
dc.language.isoenen
dc.subjectCancer Recurrenceen
dc.subjectPituitary Canceren
dc.subject.meshAdolescent-
dc.subject.meshAdult-
dc.subject.meshAge Factors-
dc.subject.meshAged-
dc.subject.meshChild-
dc.subject.meshChild, Preschool-
dc.subject.meshCombined Modality Therapy-
dc.subject.meshCraniopharyngioma-
dc.subject.meshDisease-Free Survival-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshInfant-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshMorbidity-
dc.subject.meshNeoplasm Recurrence, Local-
dc.subject.meshPituitary Neoplasms-
dc.subject.meshRadiotherapy, Adjuvant-
dc.subject.meshRetrospective Studies-
dc.subject.meshTime Factors-
dc.titleExperience of external beam radiotherapy given adjuvantly or at relapse following surgery for craniopharyngioma.en
dc.typeArticleen
dc.contributor.departmentDepartment of Clinical Oncology, Christie Hospital, Withington, UK.en
dc.identifier.journalRadiotherapy and Oncologyen

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