Late tissue effects following radiotherapy and neoadjuvant hormone therapy of the prostate measured with quantitative magnetic resonance imaging.

2.50
Hdl Handle:
http://hdl.handle.net/10541/94298
Title:
Late tissue effects following radiotherapy and neoadjuvant hormone therapy of the prostate measured with quantitative magnetic resonance imaging.
Authors:
Kershaw, Lucy E; Logue, John P; Hutchinson, Charles E; Clarke, Noel W ( 0000-0001-7776-8059 ) ; Buckley, David L
Abstract:
BACKGROUND AND PURPOSE: To use quantitative MRI to detect changes in the vascular and MR relaxation characteristics of the prostate gland 1 year after external beam radiotherapy. MATERIALS AND METHODS: Twenty-one patients underwent MRI before and after external beam radiotherapy for prostatic adenocarcinoma. Tracer kinetics analysis was applied to data from regions of interest in prostate tumour, normal prostate peripheral zone and muscle to obtain estimates of blood flow, extravascular-extracellular volume, blood volume and capillary permeability surface area product. T(1) and T(2) were also measured in these regions. RESULTS: Significant changes (p<0.05) after radiotherapy were found in all three tissues examined. Tumour blood flow was 0.34 and 0.14 ml (ml tissue)(-1) min(-1) before and after treatment, respectively, and T(1) increased from 922 to 1,070 ms. In normal peripheral zone, extravascular-extracellular volume increased from 0.21 to 0.52 ml (ml tissue)(-1), and T(2) decreased from 126 to 106 ms. In muscle, both permeability surface area product and T(2) rose, from 0.02 to 0.06 ml (ml tissue)(-1) min(-1) and from 50 to 56 ms, respectively. CONCLUSIONS: Quantitative MRI can be used to measure significant changes in both vascular and MR relaxation properties of the prostate and nearby muscle following treatment for prostate cancer using external beam radiotherapy.
Affiliation:
Imaging Science and Biomedical Engineering, University of Manchester, UK.
Citation:
Late tissue effects following radiotherapy and neoadjuvant hormone therapy of the prostate measured with quantitative magnetic resonance imaging. 2008, 88 (1):127-34 Radiother Oncol
Journal:
Radiotherapy and Oncology
Issue Date:
Jul-2008
URI:
http://hdl.handle.net/10541/94298
DOI:
10.1016/j.radonc.2008.02.018
PubMed ID:
18342969
Type:
Article
Language:
en
ISSN:
0167-8140
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorKershaw, Lucy Een
dc.contributor.authorLogue, John Pen
dc.contributor.authorHutchinson, Charles Een
dc.contributor.authorClarke, Noel Wen
dc.contributor.authorBuckley, David Len
dc.date.accessioned2010-03-15T16:58:21Z-
dc.date.available2010-03-15T16:58:21Z-
dc.date.issued2008-07-
dc.identifier.citationLate tissue effects following radiotherapy and neoadjuvant hormone therapy of the prostate measured with quantitative magnetic resonance imaging. 2008, 88 (1):127-34 Radiother Oncolen
dc.identifier.issn0167-8140-
dc.identifier.pmid18342969-
dc.identifier.doi10.1016/j.radonc.2008.02.018-
dc.identifier.urihttp://hdl.handle.net/10541/94298-
dc.description.abstractBACKGROUND AND PURPOSE: To use quantitative MRI to detect changes in the vascular and MR relaxation characteristics of the prostate gland 1 year after external beam radiotherapy. MATERIALS AND METHODS: Twenty-one patients underwent MRI before and after external beam radiotherapy for prostatic adenocarcinoma. Tracer kinetics analysis was applied to data from regions of interest in prostate tumour, normal prostate peripheral zone and muscle to obtain estimates of blood flow, extravascular-extracellular volume, blood volume and capillary permeability surface area product. T(1) and T(2) were also measured in these regions. RESULTS: Significant changes (p<0.05) after radiotherapy were found in all three tissues examined. Tumour blood flow was 0.34 and 0.14 ml (ml tissue)(-1) min(-1) before and after treatment, respectively, and T(1) increased from 922 to 1,070 ms. In normal peripheral zone, extravascular-extracellular volume increased from 0.21 to 0.52 ml (ml tissue)(-1), and T(2) decreased from 126 to 106 ms. In muscle, both permeability surface area product and T(2) rose, from 0.02 to 0.06 ml (ml tissue)(-1) min(-1) and from 50 to 56 ms, respectively. CONCLUSIONS: Quantitative MRI can be used to measure significant changes in both vascular and MR relaxation properties of the prostate and nearby muscle following treatment for prostate cancer using external beam radiotherapy.en
dc.language.isoenen
dc.subjectProstatic Canceren
dc.subject.meshAdenocarcinoma-
dc.subject.meshAged-
dc.subject.meshAntineoplastic Agents, Hormonal-
dc.subject.meshChemotherapy, Adjuvant-
dc.subject.meshCombined Modality Therapy-
dc.subject.meshContrast Media-
dc.subject.meshHumans-
dc.subject.meshMagnetic Resonance Imaging-
dc.subject.meshMale-
dc.subject.meshMicrocirculation-
dc.subject.meshMiddle Aged-
dc.subject.meshProspective Studies-
dc.subject.meshProstate-
dc.subject.meshProstatic Neoplasms-
dc.subject.meshTreatment Outcome-
dc.titleLate tissue effects following radiotherapy and neoadjuvant hormone therapy of the prostate measured with quantitative magnetic resonance imaging.en
dc.typeArticleen
dc.contributor.departmentImaging Science and Biomedical Engineering, University of Manchester, UK.en
dc.identifier.journalRadiotherapy and Oncologyen

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