Enhancing fraction measured using dynamic contrast-enhanced MRI predicts disease-free survival in patients with carcinoma of the cervix.

2.50
Hdl Handle:
http://hdl.handle.net/10541/94294
Title:
Enhancing fraction measured using dynamic contrast-enhanced MRI predicts disease-free survival in patients with carcinoma of the cervix.
Authors:
Donaldson, S B; Buckley, David L; O'Connor, James P B; Davidson, Susan E; Carrington, Bernadette M; Jones, Andrew P; West, Catharine M L
Abstract:
Background:There is a need for simple imaging parameters capable of predicting therapeutic outcome.Methods:This retrospective study analysed 50 patients with locally advanced carcinoma of the cervix who underwent dynamic contrast-enhanced MRI before receiving potentially curative radiotherapy. The proportion of enhancing pixels (E(F)) in the whole-tumour volume post-contrast agent injection was calculated and assessed in relation to disease-free survival (DFS).Results:Tumours with high E(F) had a significantly poorer probability of DFS than those with low E(F) (P=0.011).Interpretation:E(F) is a simple imaging biomarker that should be studied further in a multi-centre setting.
Affiliation:
North Western Medical Physics, The Christie, Wilmslow Road, Withington, Manchester M20 4BX, UK. Stephanie.donaldson@physics.cr.man.ac.uk
Citation:
Enhancing fraction measured using dynamic contrast-enhanced MRI predicts disease-free survival in patients with carcinoma of the cervix. 2010, 102 (1):23-6 Br. J. Cancer
Journal:
British Journal of Cancer
Issue Date:
5-Jan-2010
URI:
http://hdl.handle.net/10541/94294
DOI:
10.1038/sj.bjc.6605415
PubMed ID:
19920831
Type:
Article
Language:
en
ISSN:
1532-1827
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorDonaldson, S Ben
dc.contributor.authorBuckley, David Len
dc.contributor.authorO'Connor, James P Ben
dc.contributor.authorDavidson, Susan Een
dc.contributor.authorCarrington, Bernadette Men
dc.contributor.authorJones, Andrew Pen
dc.contributor.authorWest, Catharine M Len
dc.date.accessioned2010-03-15T16:49:52Z-
dc.date.available2010-03-15T16:49:52Z-
dc.date.issued2010-01-05-
dc.identifier.citationEnhancing fraction measured using dynamic contrast-enhanced MRI predicts disease-free survival in patients with carcinoma of the cervix. 2010, 102 (1):23-6 Br. J. Canceren
dc.identifier.issn1532-1827-
dc.identifier.pmid19920831-
dc.identifier.doi10.1038/sj.bjc.6605415-
dc.identifier.urihttp://hdl.handle.net/10541/94294-
dc.description.abstractBackground:There is a need for simple imaging parameters capable of predicting therapeutic outcome.Methods:This retrospective study analysed 50 patients with locally advanced carcinoma of the cervix who underwent dynamic contrast-enhanced MRI before receiving potentially curative radiotherapy. The proportion of enhancing pixels (E(F)) in the whole-tumour volume post-contrast agent injection was calculated and assessed in relation to disease-free survival (DFS).Results:Tumours with high E(F) had a significantly poorer probability of DFS than those with low E(F) (P=0.011).Interpretation:E(F) is a simple imaging biomarker that should be studied further in a multi-centre setting.en
dc.language.isoenen
dc.subjectCancer Metastasisen
dc.subjectCancer Recurrenceen
dc.subjectResidual Canceren
dc.subjectUterine Cervical Canceren
dc.subject.meshAdenocarcinoma-
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshAged, 80 and over-
dc.subject.meshCarcinoma, Adenosquamous-
dc.subject.meshCarcinoma, Squamous Cell-
dc.subject.meshContrast Media-
dc.subject.meshDisease-Free Survival-
dc.subject.meshFemale-
dc.subject.meshFollow-Up Studies-
dc.subject.meshGadolinium DTPA-
dc.subject.meshHumans-
dc.subject.meshImage Processing, Computer-Assisted-
dc.subject.meshKaplan-Meiers Estimate-
dc.subject.meshMagnetic Resonance Imaging-
dc.subject.meshMiddle Aged-
dc.subject.meshNeoplasm Metastasis-
dc.subject.meshNeoplasm Recurrence, Local-
dc.subject.meshNeoplasm, Residual-
dc.subject.meshNeovascularization, Pathologic-
dc.subject.meshRetrospective Studies-
dc.subject.meshUterine Cervical Neoplasms-
dc.titleEnhancing fraction measured using dynamic contrast-enhanced MRI predicts disease-free survival in patients with carcinoma of the cervix.en
dc.typeArticleen
dc.contributor.departmentNorth Western Medical Physics, The Christie, Wilmslow Road, Withington, Manchester M20 4BX, UK. Stephanie.donaldson@physics.cr.man.ac.uken
dc.identifier.journalBritish Journal of Canceren

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