A comparison of tracer kinetic models for T1-weighted dynamic contrast-enhanced MRI: application in carcinoma of the cervix.

2.50
Hdl Handle:
http://hdl.handle.net/10541/94293
Title:
A comparison of tracer kinetic models for T1-weighted dynamic contrast-enhanced MRI: application in carcinoma of the cervix.
Authors:
Donaldson, Stephanie B; West, Catharine M L; Davidson, Susan E; Carrington, Bernadette M; Hutchison, Gillian J; Jones, Andrew P; Sourbron, Steven P; Buckley, David L
Abstract:
The Tofts tracer kinetic models are often used to analyze dynamic contrast-enhanced MRI data. They are derived from a general two-compartment exchange model (2CXM) but assume negligible plasma mean transit time. The 2CXM estimates tissue plasma perfusion and capillary permeability-surface area; the Tofts models estimate the transfer constant K(trans), which reflects a combination of these two parameters. The aims of this study were to compare the 2CXM and Tofts models and report microvascular parameters in patients with cervical cancer. Thirty patients were scanned pretreatment using a dynamic contrast-enhanced MRI protocol with a 3 sec temporal resolution and a total scan duration of 4 min. Whole-tumor parameters were estimated with both models. The 2CXM provided superior fits to the data for all patients (all 30 P values < 0.005), and significantly different parameter estimates were obtained (P < 0.01). K(trans) (mean = 0.35 +/- 0.26 min(-1)) did not equal absolute values of tissue plasma perfusion (mean = 0.65 +/- 0.56 mL/mL/min) or permeability-surface area (mean = 0.14 +/- 0.09 mL/mL/min) but correlated strongly with tissue plasma perfusion (r = 0.944; P = 0.01). Average plasma mean transit time, calculated with the 2CXM, was 22 +/- 16 sec, suggesting the assumption of negligible plasma mean transit time is not appropriate in this dataset and the 2CXM is better suited for its analysis than the Tofts models. The results demonstrate the importance of selecting an appropriate tracer kinetic model in dynamic contrast-enhanced MRI.
Affiliation:
Imaging Science and Biomedical Engineering, University of Manchester, Manchester, United Kingdom.
Citation:
A comparison of tracer kinetic models for T1-weighted dynamic contrast-enhanced MRI: application in carcinoma of the cervix. 2010, 63 (3):691-700 Magn Reson Med
Journal:
Magnetic Resonance in Medicine
Issue Date:
Mar-2010
URI:
http://hdl.handle.net/10541/94293
DOI:
10.1002/mrm.22217
PubMed ID:
20187179
Type:
Article
Language:
en
ISSN:
1522-2594
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorDonaldson, Stephanie Ben
dc.contributor.authorWest, Catharine M Len
dc.contributor.authorDavidson, Susan Een
dc.contributor.authorCarrington, Bernadette Men
dc.contributor.authorHutchison, Gillian Jen
dc.contributor.authorJones, Andrew Pen
dc.contributor.authorSourbron, Steven Pen
dc.contributor.authorBuckley, David Len
dc.date.accessioned2010-03-15T16:48:02Z-
dc.date.available2010-03-15T16:48:02Z-
dc.date.issued2010-03-
dc.identifier.citationA comparison of tracer kinetic models for T1-weighted dynamic contrast-enhanced MRI: application in carcinoma of the cervix. 2010, 63 (3):691-700 Magn Reson Meden
dc.identifier.issn1522-2594-
dc.identifier.pmid20187179-
dc.identifier.doi10.1002/mrm.22217-
dc.identifier.urihttp://hdl.handle.net/10541/94293-
dc.description.abstractThe Tofts tracer kinetic models are often used to analyze dynamic contrast-enhanced MRI data. They are derived from a general two-compartment exchange model (2CXM) but assume negligible plasma mean transit time. The 2CXM estimates tissue plasma perfusion and capillary permeability-surface area; the Tofts models estimate the transfer constant K(trans), which reflects a combination of these two parameters. The aims of this study were to compare the 2CXM and Tofts models and report microvascular parameters in patients with cervical cancer. Thirty patients were scanned pretreatment using a dynamic contrast-enhanced MRI protocol with a 3 sec temporal resolution and a total scan duration of 4 min. Whole-tumor parameters were estimated with both models. The 2CXM provided superior fits to the data for all patients (all 30 P values < 0.005), and significantly different parameter estimates were obtained (P < 0.01). K(trans) (mean = 0.35 +/- 0.26 min(-1)) did not equal absolute values of tissue plasma perfusion (mean = 0.65 +/- 0.56 mL/mL/min) or permeability-surface area (mean = 0.14 +/- 0.09 mL/mL/min) but correlated strongly with tissue plasma perfusion (r = 0.944; P = 0.01). Average plasma mean transit time, calculated with the 2CXM, was 22 +/- 16 sec, suggesting the assumption of negligible plasma mean transit time is not appropriate in this dataset and the 2CXM is better suited for its analysis than the Tofts models. The results demonstrate the importance of selecting an appropriate tracer kinetic model in dynamic contrast-enhanced MRI.en
dc.language.isoenen
dc.subjectDynamic Contrast-Enhanced Magnetic Resonance Imagingen
dc.subjectTracer Kinetic Modelen
dc.subjectCervical Canceren
dc.subjectCapillary Permeabilityen
dc.titleA comparison of tracer kinetic models for T1-weighted dynamic contrast-enhanced MRI: application in carcinoma of the cervix.en
dc.typeArticleen
dc.contributor.departmentImaging Science and Biomedical Engineering, University of Manchester, Manchester, United Kingdom.en
dc.identifier.journalMagnetic Resonance in Medicineen

Related articles on PubMed

All Items in Christie are protected by copyright, with all rights reserved, unless otherwise indicated.