Polymorphism within the cyclin D1 gene is associated with prognosis in patients with squamous cell carcinoma of the head and neck.

2.50
Hdl Handle:
http://hdl.handle.net/10541/93433
Title:
Polymorphism within the cyclin D1 gene is associated with prognosis in patients with squamous cell carcinoma of the head and neck.
Authors:
Matthias, C; Branigan, K; Jahnke, V; Leder, K; Haas, J; Heighway, Jim; Jones, P W; Strange, R C; Fryer, A A; Hoban, Paul R
Abstract:
We have examined the correlation of a frequent A/G polymorphism within exon 4 of the cyclin D1 gene (CCND1) with genetic susceptibility and clinical outcome in 384 patients with squamous cell carcinoma (SCC) of the head and neck. CCND1 genotype frequencies were similar in the cases and 191 controls. Furthermore, the CCND1 genotype was not associated with susceptibility to SCC of the larynx, pharynx, or oral cavity. The influence of the CCND1 genotype on clinical outcome was also assessed. We found no correlation between genotype and tumor size (T1-T4), the involvement of nodes at presentation, or patient age and gender. However, the distribution of CCND1 genotypes in cases with poorly differentiated tumors was significantly different to that in patients with well-/moderately differentiated tumors (P = 0.016; chi2(2) = 8.71). Homozygosity for CCND1*G (GG genotype) was associated with poorly differentiated tumors (G3). We used Cox's proportional hazards model to investigate the influence of the CCND1 genotype on disease-free interval. CCND1 GG was associated with reduced disease-free interval [P = 0.001; hazard ratio (HR) = 2.95; 95% confidence interval (CI) = 1.54-5.63]. This remained significant after correction for tumor differentiation (P = 0.013; HR = 2.34; 95% CI = 1.2-4.6) and tumor stage (P = 0.005; HR = 2.64; 95% CI = 1.34-5.19). Analysis of the data from patients with tumors at different sites showed that the CCND1 GG genotype was associated with reduced disease-free interval in laryngeal (P = 0.004; HR = 3.63; 95% CI = 1.44-8.83) and pharyngeal (P = 0.006; HR = 3.48; 95% CI = 1.43-8.46) tumors. This is the first report of an association between CCND1 polymorphism and prognosis in SCC of the head and neck. These data show that the CCND1 GG genotype is an independent prognostic indicator of disease-free interval and supports initial observations in non-small cell lung cancer, that polymorphism within CCND1 influences tumor behavior.
Affiliation:
Department of Otorhinolaryngology, Charite-Hospital, Humboldt-University, Berlin, Germany.
Citation:
Polymorphism within the cyclin D1 gene is associated with prognosis in patients with squamous cell carcinoma of the head and neck. 1998, 4 (10):2411-8 Clin. Cancer Res.
Journal:
Clinical Cancer Research
Issue Date:
Oct-1998
URI:
http://hdl.handle.net/10541/93433
PubMed ID:
9796972
Type:
Article
Language:
en
ISSN:
1078-0432
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorMatthias, Cen
dc.contributor.authorBranigan, Ken
dc.contributor.authorJahnke, Ven
dc.contributor.authorLeder, Ken
dc.contributor.authorHaas, Jen
dc.contributor.authorHeighway, Jimen
dc.contributor.authorJones, P Wen
dc.contributor.authorStrange, R Cen
dc.contributor.authorFryer, A Aen
dc.contributor.authorHoban, Paul Ren
dc.date.accessioned2010-03-02T17:21:18Z-
dc.date.available2010-03-02T17:21:18Z-
dc.date.issued1998-10-
dc.identifier.citationPolymorphism within the cyclin D1 gene is associated with prognosis in patients with squamous cell carcinoma of the head and neck. 1998, 4 (10):2411-8 Clin. Cancer Res.en
dc.identifier.issn1078-0432-
dc.identifier.pmid9796972-
dc.identifier.urihttp://hdl.handle.net/10541/93433-
dc.description.abstractWe have examined the correlation of a frequent A/G polymorphism within exon 4 of the cyclin D1 gene (CCND1) with genetic susceptibility and clinical outcome in 384 patients with squamous cell carcinoma (SCC) of the head and neck. CCND1 genotype frequencies were similar in the cases and 191 controls. Furthermore, the CCND1 genotype was not associated with susceptibility to SCC of the larynx, pharynx, or oral cavity. The influence of the CCND1 genotype on clinical outcome was also assessed. We found no correlation between genotype and tumor size (T1-T4), the involvement of nodes at presentation, or patient age and gender. However, the distribution of CCND1 genotypes in cases with poorly differentiated tumors was significantly different to that in patients with well-/moderately differentiated tumors (P = 0.016; chi2(2) = 8.71). Homozygosity for CCND1*G (GG genotype) was associated with poorly differentiated tumors (G3). We used Cox's proportional hazards model to investigate the influence of the CCND1 genotype on disease-free interval. CCND1 GG was associated with reduced disease-free interval [P = 0.001; hazard ratio (HR) = 2.95; 95% confidence interval (CI) = 1.54-5.63]. This remained significant after correction for tumor differentiation (P = 0.013; HR = 2.34; 95% CI = 1.2-4.6) and tumor stage (P = 0.005; HR = 2.64; 95% CI = 1.34-5.19). Analysis of the data from patients with tumors at different sites showed that the CCND1 GG genotype was associated with reduced disease-free interval in laryngeal (P = 0.004; HR = 3.63; 95% CI = 1.44-8.83) and pharyngeal (P = 0.006; HR = 3.48; 95% CI = 1.43-8.46) tumors. This is the first report of an association between CCND1 polymorphism and prognosis in SCC of the head and neck. These data show that the CCND1 GG genotype is an independent prognostic indicator of disease-free interval and supports initial observations in non-small cell lung cancer, that polymorphism within CCND1 influences tumor behavior.en
dc.language.isoenen
dc.subjectHead and Neck Canceren
dc.subjectCancer Recurrenceen
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshCarcinoma, Squamous Cell-
dc.subject.meshCyclin D1-
dc.subject.meshFemale-
dc.subject.meshGenotype-
dc.subject.meshHead and Neck Neoplasms-
dc.subject.meshHumans-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshNeoplasm Recurrence, Local-
dc.subject.meshPolymorphism, Genetic-
dc.subject.meshPrognosis-
dc.titlePolymorphism within the cyclin D1 gene is associated with prognosis in patients with squamous cell carcinoma of the head and neck.en
dc.typeArticleen
dc.contributor.departmentDepartment of Otorhinolaryngology, Charite-Hospital, Humboldt-University, Berlin, Germany.en
dc.identifier.journalClinical Cancer Researchen

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