Tubulin as a target for anticancer drugs: agents which interact with the mitotic spindle.

2.50
Hdl Handle:
http://hdl.handle.net/10541/93081
Title:
Tubulin as a target for anticancer drugs: agents which interact with the mitotic spindle.
Authors:
Jordan, Allan M; Hadfield, John A; Lawrence, N J; McGown, Alan T
Abstract:
Tubulin is the biochemical target for several clinically used anticancer drugs, including paclitaxel and the vinca alkaloids vincristine and vinblastine. This review describes both the natural and synthetic agents which are known to interact with tubulin. Syntheses of the more complex agents are referenced and the potential clinical use of the compounds is discussed. This review describes the biochemistry of tubulin, microtubules, and the mitotic spindle. The agents are discussed in relation to the type of binding site on the protein with which they interact. These are the colchicine, vinca alkaloid, rhizoxin/maytansine, and tubulin sulfhydryl binding sites. Also included are the agents which either bind at other sites or unknown sites on tubulin. The literature is reviewed up to October 1997.
Affiliation:
Department of Chemistry, University of Manchester Institute of Science and Technology, UK.
Citation:
Tubulin as a target for anticancer drugs: agents which interact with the mitotic spindle. 1998, 18 (4):259-96 Med Res Rev
Journal:
Medicinal Research Reviews
Issue Date:
Jul-1998
URI:
http://hdl.handle.net/10541/93081
PubMed ID:
9664292
Type:
Article
Language:
en
ISSN:
0198-6325
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorJordan, Allan Men
dc.contributor.authorHadfield, John Aen
dc.contributor.authorLawrence, N Jen
dc.contributor.authorMcGown, Alan Ten
dc.date.accessioned2010-02-25T15:11:37Z-
dc.date.available2010-02-25T15:11:37Z-
dc.date.issued1998-07-
dc.identifier.citationTubulin as a target for anticancer drugs: agents which interact with the mitotic spindle. 1998, 18 (4):259-96 Med Res Reven
dc.identifier.issn0198-6325-
dc.identifier.pmid9664292-
dc.identifier.urihttp://hdl.handle.net/10541/93081-
dc.description.abstractTubulin is the biochemical target for several clinically used anticancer drugs, including paclitaxel and the vinca alkaloids vincristine and vinblastine. This review describes both the natural and synthetic agents which are known to interact with tubulin. Syntheses of the more complex agents are referenced and the potential clinical use of the compounds is discussed. This review describes the biochemistry of tubulin, microtubules, and the mitotic spindle. The agents are discussed in relation to the type of binding site on the protein with which they interact. These are the colchicine, vinca alkaloid, rhizoxin/maytansine, and tubulin sulfhydryl binding sites. Also included are the agents which either bind at other sites or unknown sites on tubulin. The literature is reviewed up to October 1997.en
dc.language.isoenen
dc.subject.meshAntibiotics, Antineoplastic-
dc.subject.meshAntineoplastic Agents-
dc.subject.meshAntineoplastic Agents, Phytogenic-
dc.subject.meshBinding Sites-
dc.subject.meshColchicine-
dc.subject.meshDrug Design-
dc.subject.meshHumans-
dc.subject.meshLactones-
dc.subject.meshMacrolides-
dc.subject.meshMaytansine-
dc.subject.meshMicrotubules-
dc.subject.meshMitotic Spindle Apparatus-
dc.subject.meshPaclitaxel-
dc.subject.meshProtein Binding-
dc.subject.meshSulfhydryl Reagents-
dc.subject.meshTubulin-
dc.subject.meshTubulin Modulators-
dc.subject.meshVinblastine-
dc.subject.meshVincristine-
dc.titleTubulin as a target for anticancer drugs: agents which interact with the mitotic spindle.en
dc.typeArticleen
dc.contributor.departmentDepartment of Chemistry, University of Manchester Institute of Science and Technology, UK.en
dc.identifier.journalMedicinal Research Reviewsen

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