Antimitotic activity of diaryl compounds with structural features resembling combretastatin A-4.

2.50
Hdl Handle:
http://hdl.handle.net/10541/93072
Title:
Antimitotic activity of diaryl compounds with structural features resembling combretastatin A-4.
Authors:
Aleksandrzak, Krzysztof; McGown, Alan T; Hadfield, John A
Abstract:
Series of diaryl ethers, amines and amides have been synthesized and tested for antitumor activity. These diaryl compounds possess some of the structural features of combretastatin A-4 (a potent antimitotic agent). They were designed to discover whether transferring these structural motifs from stilbenes to heterosubstituted diaryl compounds would enhance their biochemical activities. Molecular modeling studies suggested that these diaryl compounds could adopt conformations similar to combretastatin A-4. However, although some agents (5-7) were cytotoxic and others (10 and 12) could interact with tubulin, none were as potent as combretastatin A-4.
Affiliation:
Cancer Research Campaign Section of Drug Development and Imaging, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, UK.
Citation:
Antimitotic activity of diaryl compounds with structural features resembling combretastatin A-4. 1998, 9 (6):545-50 Anticancer Drugs
Journal:
Anti-Cancer Drugs
Issue Date:
Jul-1998
URI:
http://hdl.handle.net/10541/93072
PubMed ID:
9877243
Type:
Article
Language:
en
ISSN:
0959-4973
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorAleksandrzak, Krzysztofen
dc.contributor.authorMcGown, Alan Ten
dc.contributor.authorHadfield, John Aen
dc.date.accessioned2010-02-25T15:01:00Z-
dc.date.available2010-02-25T15:01:00Z-
dc.date.issued1998-07-
dc.identifier.citationAntimitotic activity of diaryl compounds with structural features resembling combretastatin A-4. 1998, 9 (6):545-50 Anticancer Drugsen
dc.identifier.issn0959-4973-
dc.identifier.pmid9877243-
dc.identifier.urihttp://hdl.handle.net/10541/93072-
dc.description.abstractSeries of diaryl ethers, amines and amides have been synthesized and tested for antitumor activity. These diaryl compounds possess some of the structural features of combretastatin A-4 (a potent antimitotic agent). They were designed to discover whether transferring these structural motifs from stilbenes to heterosubstituted diaryl compounds would enhance their biochemical activities. Molecular modeling studies suggested that these diaryl compounds could adopt conformations similar to combretastatin A-4. However, although some agents (5-7) were cytotoxic and others (10 and 12) could interact with tubulin, none were as potent as combretastatin A-4.en
dc.language.isoenen
dc.subjectAntitumour Drug Screening Assaysen
dc.subjectLeukaemia P388en
dc.subjectCultured Tumour Cellsen
dc.subject.meshAnimals-
dc.subject.meshAntineoplastic Agents, Phytogenic-
dc.subject.meshBibenzyls-
dc.subject.meshDrug Screening Assays, Antitumor-
dc.subject.meshLeukemia P388-
dc.subject.meshMice-
dc.subject.meshStilbenes-
dc.subject.meshStructure-Activity Relationship-
dc.subject.meshTumor Cells, Cultured-
dc.titleAntimitotic activity of diaryl compounds with structural features resembling combretastatin A-4.en
dc.typeArticleen
dc.contributor.departmentCancer Research Campaign Section of Drug Development and Imaging, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, UK.en
dc.identifier.journalAnti-Cancer Drugsen

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