Photodynamic therapy of ovarian tumours and normal cells using 5,10,15,20-tetra-(3-carboxymethoxyphenyl)-chlorin.

2.50
Hdl Handle:
http://hdl.handle.net/10541/93063
Title:
Photodynamic therapy of ovarian tumours and normal cells using 5,10,15,20-tetra-(3-carboxymethoxyphenyl)-chlorin.
Authors:
Griffiths, S J; Heelis, P F; Haylett, Ann K; Moore, James V
Abstract:
The photosensitizing ability of the second generation photosensitizer 5,10,15,20-tetra-(3-carboxymethoxyphenyl)-chlorin (m-TCMPC), a derivative of m-THPC, was tested on both three-dimensional multicellular spheroids of varying sizes and on monolayer cultures. These experiments were carried out on two spheroid-forming cell lines, A2780 (a human ovarian adenocarcinoma) and CHO (Chinese hamster ovarian cells). For both cell lines, photodynamic therapy (sensitizer plus visible light) treatments were carried out. The chlorin m-TCMPC was shown to have considerable promise as a photosensitizing agent. Cell kill was achieved for all situations tested, i.e. monolayer, 100, 500 and 750 microm spheroids. In addition no significant dark toxicity was observed.
Affiliation:
School of Science and Technology, North East Wales Institute, Wrexham, UK.
Citation:
Photodynamic therapy of ovarian tumours and normal cells using 5,10,15,20-tetra-(3-carboxymethoxyphenyl)-chlorin. 1998, 125 (1-2):177-84 Cancer Lett.
Journal:
Cancer Letters
Issue Date:
13-Mar-1998
URI:
http://hdl.handle.net/10541/93063
PubMed ID:
9566713
Type:
Article
Language:
en
ISSN:
0304-3835
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorGriffiths, S Jen
dc.contributor.authorHeelis, P Fen
dc.contributor.authorHaylett, Ann Ken
dc.contributor.authorMoore, James Ven
dc.date.accessioned2010-02-25T14:54:25Z-
dc.date.available2010-02-25T14:54:25Z-
dc.date.issued1998-03-13-
dc.identifier.citationPhotodynamic therapy of ovarian tumours and normal cells using 5,10,15,20-tetra-(3-carboxymethoxyphenyl)-chlorin. 1998, 125 (1-2):177-84 Cancer Lett.en
dc.identifier.issn0304-3835-
dc.identifier.pmid9566713-
dc.identifier.urihttp://hdl.handle.net/10541/93063-
dc.description.abstractThe photosensitizing ability of the second generation photosensitizer 5,10,15,20-tetra-(3-carboxymethoxyphenyl)-chlorin (m-TCMPC), a derivative of m-THPC, was tested on both three-dimensional multicellular spheroids of varying sizes and on monolayer cultures. These experiments were carried out on two spheroid-forming cell lines, A2780 (a human ovarian adenocarcinoma) and CHO (Chinese hamster ovarian cells). For both cell lines, photodynamic therapy (sensitizer plus visible light) treatments were carried out. The chlorin m-TCMPC was shown to have considerable promise as a photosensitizing agent. Cell kill was achieved for all situations tested, i.e. monolayer, 100, 500 and 750 microm spheroids. In addition no significant dark toxicity was observed.en
dc.language.isoenen
dc.subjectCultured Tumour Cellsen
dc.subjectOvarian Canceren
dc.subject.meshAnimals-
dc.subject.meshCHO Cells-
dc.subject.meshCell Division-
dc.subject.meshCell Survival-
dc.subject.meshCricetinae-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshMesoporphyrins-
dc.subject.meshOvarian Neoplasms-
dc.subject.meshPhotochemotherapy-
dc.subject.meshPhotosensitizing Agents-
dc.subject.meshSpheroids, Cellular-
dc.subject.meshTumor Cells, Cultured-
dc.titlePhotodynamic therapy of ovarian tumours and normal cells using 5,10,15,20-tetra-(3-carboxymethoxyphenyl)-chlorin.en
dc.typeArticleen
dc.contributor.departmentSchool of Science and Technology, North East Wales Institute, Wrexham, UK.en
dc.identifier.journalCancer Lettersen

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