A dynamic model of proliferation and differentiation in the intestinal crypt based on a hypothetical intraepithelial growth factor.

2.50
Hdl Handle:
http://hdl.handle.net/10541/93051
Title:
A dynamic model of proliferation and differentiation in the intestinal crypt based on a hypothetical intraepithelial growth factor.
Authors:
Gerike, T G; Paulus, U; Potten, Christopher S; Loeffler, M
Abstract:
A widely accepted model of the temporal and spatial organization of proliferation and differentiation in intestinal epithelial is based on a cellular pedigree with all cells descending from a few active stem cells and undergoing a sequence of transitory divisions until the non-proliferating maturing cell stages develop. Model simulations have shown that such a pedigree concept can explain a large variety of data. However, so far there is neither a direct experimental proof for the existence of an intrinsic age structure in the transitory proliferative cell stages nor for the distinction between stem and transitory cells. It is our objective to suggest an alternative model which is based on evidence for intercellular communications such as might be mediated through gap junctions. We consider the diffusion of a hypothetical intraepithelial growth factor in a chain of cells which are connected via gap junctions. Individual cells can divide if a critical growth factor concentration is exceeded. Simulation studies show that the model is consistent with many observed features of the small intestinal crypt in steady state and after perturbation.
Affiliation:
Institut für Medizinische Informatik, Statistik und Epidemiologie, Leipzig, Germany.
Citation:
A dynamic model of proliferation and differentiation in the intestinal crypt based on a hypothetical intraepithelial growth factor. 1998, 31 (2):93-110 Cell Prolif.
Journal:
Cell proliferation
Issue Date:
Apr-1998
URI:
http://hdl.handle.net/10541/93051
PubMed ID:
9745618
Type:
Article
Language:
en
ISSN:
0960-7722
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorGerike, T Gen
dc.contributor.authorPaulus, Uen
dc.contributor.authorPotten, Christopher Sen
dc.contributor.authorLoeffler, Men
dc.date.accessioned2010-02-25T14:55:09Z-
dc.date.available2010-02-25T14:55:09Z-
dc.date.issued1998-04-
dc.identifier.citationA dynamic model of proliferation and differentiation in the intestinal crypt based on a hypothetical intraepithelial growth factor. 1998, 31 (2):93-110 Cell Prolif.en
dc.identifier.issn0960-7722-
dc.identifier.pmid9745618-
dc.identifier.urihttp://hdl.handle.net/10541/93051-
dc.description.abstractA widely accepted model of the temporal and spatial organization of proliferation and differentiation in intestinal epithelial is based on a cellular pedigree with all cells descending from a few active stem cells and undergoing a sequence of transitory divisions until the non-proliferating maturing cell stages develop. Model simulations have shown that such a pedigree concept can explain a large variety of data. However, so far there is neither a direct experimental proof for the existence of an intrinsic age structure in the transitory proliferative cell stages nor for the distinction between stem and transitory cells. It is our objective to suggest an alternative model which is based on evidence for intercellular communications such as might be mediated through gap junctions. We consider the diffusion of a hypothetical intraepithelial growth factor in a chain of cells which are connected via gap junctions. Individual cells can divide if a critical growth factor concentration is exceeded. Simulation studies show that the model is consistent with many observed features of the small intestinal crypt in steady state and after perturbation.en
dc.language.isoenen
dc.subject.meshAnimals-
dc.subject.meshCell Communication-
dc.subject.meshCell Cycle-
dc.subject.meshCell Differentiation-
dc.subject.meshCell Division-
dc.subject.meshDNA Replication-
dc.subject.meshGrowth Substances-
dc.subject.meshIntestinal Mucosa-
dc.subject.meshKinetics-
dc.subject.meshModels, Biological-
dc.subject.meshTime Factors-
dc.titleA dynamic model of proliferation and differentiation in the intestinal crypt based on a hypothetical intraepithelial growth factor.en
dc.typeArticleen
dc.contributor.departmentInstitut für Medizinische Informatik, Statistik und Epidemiologie, Leipzig, Germany.en
dc.identifier.journalCell proliferationen
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