2.50
Hdl Handle:
http://hdl.handle.net/10541/93048
Title:
Colonic cell proliferation in normal mucosa of patients with colon cancer.
Authors:
Becciolini, A; Balzi, M; Faraoni, P; Tisti, E; Zappoli Thyrion, G; Giachè, V; Bandettini, L; Potten, Christopher S
Abstract:
Cell kinetics parameters have been analysed in colonic mucosa at different distances from a tumour in patients with colon carcinoma. Total cell number (TCN), 3H thymidine labelling index (TLI), mitotic index (MI), Goblet cell index (GCI) and the distribution of labelled cells along the crypt column (cell position frequency plot) were determined in well-aligned crypts. Total cell number, GCI and the labelled cell position frequency plots were similar in different samples from the same individual. A negative linear correlation between TCN and TLI was observed. The analysis of the cell position plots showed two patterns 1) with a high concentration in the bottom fifth of the crypt and 2) with frequent labelled cells at high positions. Whereas a negative correlation between overall TLI and the percent contribution to the TLI of the lowermost fifth was seen, the correlation was positive for the next 3 fifths and labelling was absent in the last part of the crypt.
Affiliation:
Department of Clinical Physiopathology, University of Florence, Italy.
Citation:
Colonic cell proliferation in normal mucosa of patients with colon cancer. 1998, 37 (1):65-71 Acta Oncol
Journal:
Acta Oncologica
Issue Date:
1998
URI:
http://hdl.handle.net/10541/93048
PubMed ID:
9572656
Type:
Article
Language:
en
ISSN:
0284-186X
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorBecciolini, Aen
dc.contributor.authorBalzi, Men
dc.contributor.authorFaraoni, Pen
dc.contributor.authorTisti, Een
dc.contributor.authorZappoli Thyrion, Gen
dc.contributor.authorGiachè, Ven
dc.contributor.authorBandettini, Len
dc.contributor.authorPotten, Christopher Sen
dc.date.accessioned2010-02-25T14:53:27Z-
dc.date.available2010-02-25T14:53:27Z-
dc.date.issued1998-
dc.identifier.citationColonic cell proliferation in normal mucosa of patients with colon cancer. 1998, 37 (1):65-71 Acta Oncolen
dc.identifier.issn0284-186X-
dc.identifier.pmid9572656-
dc.identifier.urihttp://hdl.handle.net/10541/93048-
dc.description.abstractCell kinetics parameters have been analysed in colonic mucosa at different distances from a tumour in patients with colon carcinoma. Total cell number (TCN), 3H thymidine labelling index (TLI), mitotic index (MI), Goblet cell index (GCI) and the distribution of labelled cells along the crypt column (cell position frequency plot) were determined in well-aligned crypts. Total cell number, GCI and the labelled cell position frequency plots were similar in different samples from the same individual. A negative linear correlation between TCN and TLI was observed. The analysis of the cell position plots showed two patterns 1) with a high concentration in the bottom fifth of the crypt and 2) with frequent labelled cells at high positions. Whereas a negative correlation between overall TLI and the percent contribution to the TLI of the lowermost fifth was seen, the correlation was positive for the next 3 fifths and labelling was absent in the last part of the crypt.en
dc.language.isoenen
dc.subjectColonic Canceren
dc.subject.meshAged-
dc.subject.meshAged, 80 and over-
dc.subject.meshCarcinoma-
dc.subject.meshCell Count-
dc.subject.meshCell Division-
dc.subject.meshColonic Neoplasms-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshIntestinal Mucosa-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshMitotic Index-
dc.subject.meshRegression Analysis-
dc.titleColonic cell proliferation in normal mucosa of patients with colon cancer.en
dc.typeArticleen
dc.contributor.departmentDepartment of Clinical Physiopathology, University of Florence, Italy.en
dc.identifier.journalActa Oncologicaen

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