Potent antimitotic and cell growth inhibitory properties of substituted chalcones.

2.50
Hdl Handle:
http://hdl.handle.net/10541/93022
Title:
Potent antimitotic and cell growth inhibitory properties of substituted chalcones.
Authors:
Ducki, Sylvie W; Forrest, R; Hadfield, John A; Kendall, A; Lawrence, N J; McGown, Alan T; Rennison, David
Abstract:
A series of substituted chalcones was synthesised and screened for cytotoxic activity against the K562 human leukaemia cell line. (E)-3-(3"-Hydroxy-4"-methoxyphenyl)-2-methyl-1-(3',4',5'- trimethoxyphenyl)-prop-2-en-1-one [IC50 (K562) 0.21 nM] was found to be the most active. A relationship between the conformation and cytotoxicity of the chalcones is discussed.
Affiliation:
Dept. of Chemistry, University of Manchester Institute of Science and Technology, UK.
Citation:
Potent antimitotic and cell growth inhibitory properties of substituted chalcones. 1998, 8 (9):1051-6 Bioorg. Med. Chem. Lett.
Journal:
Bioorganic & Medicinal Chemistry Letters
Issue Date:
5-May-1998
URI:
http://hdl.handle.net/10541/93022
PubMed ID:
9871706
Type:
Article
Language:
en
ISSN:
0960-894X
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorDucki, Sylvie Wen
dc.contributor.authorForrest, Ren
dc.contributor.authorHadfield, John Aen
dc.contributor.authorKendall, Aen
dc.contributor.authorLawrence, N Jen
dc.contributor.authorMcGown, Alan Ten
dc.contributor.authorRennison, Daviden
dc.date.accessioned2010-02-25T11:19:18Z-
dc.date.available2010-02-25T11:19:18Z-
dc.date.issued1998-05-05-
dc.identifier.citationPotent antimitotic and cell growth inhibitory properties of substituted chalcones. 1998, 8 (9):1051-6 Bioorg. Med. Chem. Lett.en
dc.identifier.issn0960-894X-
dc.identifier.pmid9871706-
dc.identifier.urihttp://hdl.handle.net/10541/93022-
dc.description.abstractA series of substituted chalcones was synthesised and screened for cytotoxic activity against the K562 human leukaemia cell line. (E)-3-(3"-Hydroxy-4"-methoxyphenyl)-2-methyl-1-(3',4',5'- trimethoxyphenyl)-prop-2-en-1-one [IC50 (K562) 0.21 nM] was found to be the most active. A relationship between the conformation and cytotoxicity of the chalcones is discussed.en
dc.language.isoenen
dc.subject.meshAntineoplastic Agents-
dc.subject.meshCell Cycle-
dc.subject.meshCell Division-
dc.subject.meshCell Survival-
dc.subject.meshChalcone-
dc.subject.meshCrystallography, X-Ray-
dc.subject.meshDrug Design-
dc.subject.meshHumans-
dc.subject.meshK562 Cells-
dc.subject.meshModels, Molecular-
dc.subject.meshMolecular Conformation-
dc.subject.meshMolecular Structure-
dc.subject.meshStructure-Activity Relationship-
dc.titlePotent antimitotic and cell growth inhibitory properties of substituted chalcones.en
dc.typeArticleen
dc.contributor.departmentDept. of Chemistry, University of Manchester Institute of Science and Technology, UK.en
dc.identifier.journalBioorganic & Medicinal Chemistry Lettersen

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