Immunization of common marmosets with Epstein-Barr virus (EBV) envelope glycoprotein gp340: effect on viral shedding following EBV challenge.

2.50
Hdl Handle:
http://hdl.handle.net/10541/93002
Title:
Immunization of common marmosets with Epstein-Barr virus (EBV) envelope glycoprotein gp340: effect on viral shedding following EBV challenge.
Authors:
Cox, C; Naylor, B A; Mackett, Mike; Arrand, John R; Griffin, B E; Wedderburn, N
Abstract:
Epstein-Barr virus (EBV), the cause of infectious mononucleosis, is involved in the pathogenesis of several human cancers, the highest frequency of association being found in undifferentiated nasopharyngeal carcinoma and endemic Burkitt's lymphoma. The development of animal models in which potential vaccines can be tested is important. EBV infection of the common marmoset, using the M81 strain originally derived from a patient with nasopharyngeal carcinoma, induces a carrier state in this animal. Persistent infection is characterized by the production of antibodies to viral antigens, and the secretion of EBV DNA into buccal fluids. Following immunization with envelope glycoprotein gp340 derived from a bovine papilloma virus expression vector, prior to EBV infection, viral DNA was detected significantly less frequently in the buccal fluids of immunized, than of nonimmunized, infected animals, indicating that although the carrier state had not been abolished, it had been altered. A reduction in virus load was also observed when offspring of seronegative, and on occasion seropositive, parents were immunized neonatally, before EBV challenge.
Affiliation:
Department of Pathology, Royal College of Surgeons of England, London, England, UK.
Citation:
Immunization of common marmosets with Epstein-Barr virus (EBV) envelope glycoprotein gp340: effect on viral shedding following EBV challenge. 1998, 55 (4):255-61 J. Med. Virol.
Journal:
Journal of Medical Virology
Issue Date:
Aug-1998
URI:
http://hdl.handle.net/10541/93002
PubMed ID:
9661832
Type:
Article
Language:
en
ISSN:
0146-6615
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorCox, Cen
dc.contributor.authorNaylor, B Aen
dc.contributor.authorMackett, Mikeen
dc.contributor.authorArrand, John Ren
dc.contributor.authorGriffin, B Een
dc.contributor.authorWedderburn, Nen
dc.date.accessioned2010-02-25T11:24:30Z-
dc.date.available2010-02-25T11:24:30Z-
dc.date.issued1998-08-
dc.identifier.citationImmunization of common marmosets with Epstein-Barr virus (EBV) envelope glycoprotein gp340: effect on viral shedding following EBV challenge. 1998, 55 (4):255-61 J. Med. Virol.en
dc.identifier.issn0146-6615-
dc.identifier.pmid9661832-
dc.identifier.urihttp://hdl.handle.net/10541/93002-
dc.description.abstractEpstein-Barr virus (EBV), the cause of infectious mononucleosis, is involved in the pathogenesis of several human cancers, the highest frequency of association being found in undifferentiated nasopharyngeal carcinoma and endemic Burkitt's lymphoma. The development of animal models in which potential vaccines can be tested is important. EBV infection of the common marmoset, using the M81 strain originally derived from a patient with nasopharyngeal carcinoma, induces a carrier state in this animal. Persistent infection is characterized by the production of antibodies to viral antigens, and the secretion of EBV DNA into buccal fluids. Following immunization with envelope glycoprotein gp340 derived from a bovine papilloma virus expression vector, prior to EBV infection, viral DNA was detected significantly less frequently in the buccal fluids of immunized, than of nonimmunized, infected animals, indicating that although the carrier state had not been abolished, it had been altered. A reduction in virus load was also observed when offspring of seronegative, and on occasion seropositive, parents were immunized neonatally, before EBV challenge.en
dc.language.isoenen
dc.subjectTumour Virus Infectionsen
dc.subject.meshAnimals-
dc.subject.meshAntibodies, Viral-
dc.subject.meshAntigens, Viral-
dc.subject.meshCallithrix-
dc.subject.meshCapsid Proteins-
dc.subject.meshDNA, Viral-
dc.subject.meshFemale-
dc.subject.meshHerpesviridae Infections-
dc.subject.meshHerpesvirus 4, Human-
dc.subject.meshImmunization-
dc.subject.meshMale-
dc.subject.meshTumor Virus Infections-
dc.subject.meshViral Load-
dc.subject.meshViral Matrix Proteins-
dc.subject.meshViral Vaccines-
dc.subject.meshVirus Shedding-
dc.titleImmunization of common marmosets with Epstein-Barr virus (EBV) envelope glycoprotein gp340: effect on viral shedding following EBV challenge.en
dc.typeArticleen
dc.contributor.departmentDepartment of Pathology, Royal College of Surgeons of England, London, England, UK.en
dc.identifier.journalJournal of Medical Virologyen

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