Loss of heterozygosity at chromosome 9p in ductal carcinoma in situ and invasive carcinoma of the breast.

2.50
Hdl Handle:
http://hdl.handle.net/10541/92916
Title:
Loss of heterozygosity at chromosome 9p in ductal carcinoma in situ and invasive carcinoma of the breast.
Authors:
Marsh, K L; Varley, Jennifer
Abstract:
Twenty-three cases of ductal carcinoma in situ (DCIS), ten of which had an associated invasive component, were studied for loss of heterozygosity (LOH) of microsatellite markers on chromosome 9p and the results compared with a panel of 20 invasive breast carcinomas. In addition to the gene encoding p16, chromosome 9p is also thought to contain other putative tumour-suppressor genes. If the three panels of breast tumours showed LOH of markers in this region this would suggest that such putative genes were important in breast carcinogenesis. By studying both preinvasive and invasive breast tumours, it should also be possible to gain further information about the relationship between lesions of a different stage and to determine whether DCIS is indeed a precursor of invasive ductal carcinoma. Levels of LOH were low in the invasive-only set of tumours. Surprisingly, considerably higher levels of loss were observed in the tumours with an in situ component. Also, much heterogeneity was observed between different DCIS ducts or invasive tumour and DCIS from the same case.
Affiliation:
CRC Department of Cancer Genetics, Paterson Institute for Cancer Research, Christie Hospital, Manchester, UK.
Citation:
Loss of heterozygosity at chromosome 9p in ductal carcinoma in situ and invasive carcinoma of the breast. 1998, 77 (9):1439-47 Br. J. Cancer
Journal:
British Journal of Cancer
Issue Date:
May-1998
URI:
http://hdl.handle.net/10541/92916
PubMed ID:
9652759
Type:
Article
Language:
en
ISSN:
0007-0920
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorMarsh, K Len
dc.contributor.authorVarley, Jenniferen
dc.date.accessioned2010-02-24T13:17:41Z-
dc.date.available2010-02-24T13:17:41Z-
dc.date.issued1998-05-
dc.identifier.citationLoss of heterozygosity at chromosome 9p in ductal carcinoma in situ and invasive carcinoma of the breast. 1998, 77 (9):1439-47 Br. J. Canceren
dc.identifier.issn0007-0920-
dc.identifier.pmid9652759-
dc.identifier.urihttp://hdl.handle.net/10541/92916-
dc.description.abstractTwenty-three cases of ductal carcinoma in situ (DCIS), ten of which had an associated invasive component, were studied for loss of heterozygosity (LOH) of microsatellite markers on chromosome 9p and the results compared with a panel of 20 invasive breast carcinomas. In addition to the gene encoding p16, chromosome 9p is also thought to contain other putative tumour-suppressor genes. If the three panels of breast tumours showed LOH of markers in this region this would suggest that such putative genes were important in breast carcinogenesis. By studying both preinvasive and invasive breast tumours, it should also be possible to gain further information about the relationship between lesions of a different stage and to determine whether DCIS is indeed a precursor of invasive ductal carcinoma. Levels of LOH were low in the invasive-only set of tumours. Surprisingly, considerably higher levels of loss were observed in the tumours with an in situ component. Also, much heterogeneity was observed between different DCIS ducts or invasive tumour and DCIS from the same case.en
dc.language.isoenen
dc.subjectBreast Canceren
dc.subjectCancer DNAen
dc.subjectCancer Invasivenessen
dc.subject.meshBreast Neoplasms-
dc.subject.meshCarcinoma in Situ-
dc.subject.meshCarcinoma, Ductal, Breast-
dc.subject.meshChromosomes, Human, Pair 9-
dc.subject.meshDNA, Neoplasm-
dc.subject.meshFemale-
dc.subject.meshGenetic Markers-
dc.subject.meshHumans-
dc.subject.meshLoss of Heterozygosity-
dc.subject.meshNeoplasm Invasiveness-
dc.titleLoss of heterozygosity at chromosome 9p in ductal carcinoma in situ and invasive carcinoma of the breast.en
dc.typeArticleen
dc.contributor.departmentCRC Department of Cancer Genetics, Paterson Institute for Cancer Research, Christie Hospital, Manchester, UK.en
dc.identifier.journalBritish Journal of Canceren

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