Incident cancer burden attributable to excess body mass index in 30 European countries.

2.50
Hdl Handle:
http://hdl.handle.net/10541/92837
Title:
Incident cancer burden attributable to excess body mass index in 30 European countries.
Authors:
Renehan, Andrew G; Soerjomataram, Isabelle; Tyson, Margaret; Egger, Matthias; Zwahlen, Marcel; Coebergh, Jan-Willem; Buchan, Iain
Abstract:
Excess adiposity is associated with increased risks of developing adult malignancies. To inform public health policy and guide further research, the incident cancer burden attributable to excess body mass index (BMI >or= 25 kg/m(2)) across 30 European countries were estimated. Population attributable risks (PARs) were calculated using European- and gender-specific risk estimates from a published meta-analysis and gender-specific mean BMI estimates from a World Health Organization Global Infobase. Country-specific numbers of new cancers were derived from Globocan2002. A ten-year lag-period between risk exposure and cancer incidence was assumed and 95% confidence intervals (CI) were estimated in Monte Carlo simulations. In 2002, there were 2,171,351 new all cancer diagnoses in the 30 countries of Europe. Estimated PARs were 2.5% (95% CI 1.5-3.6%) in men and 4.1% (2.3-5.9%) in women. These collectively corresponded to 70,288 (95% CI 40,069-100,668) new cases. Sensitivity analyses revealed estimates were most influenced by the assumed shape of the BMI distribution in the population and cancer-specific risk estimates. In a scenario analysis of a plausible contemporary (2008) population, the estimated PARs increased to 3.2% (2.1-4.3%) and 8.6% (5.6-11.5%), respectively, in men and women. Endometrial, post-menopausal breast and colorectal cancers accounted for 65% of these cancers. This analysis quantifies the burden of incident cancers attributable to excess BMI in Europe. The estimates reported here provide a baseline for future modelling, and underline the need for research into interventions to control weight in the context of endometrial, breast and colorectal cancer.
Affiliation:
Department of Surgery, School of Cancer, Enabling Sciences and Technology, University of Manchester, Manchester Academic Health Science Centre, The Christie NHS Foundation Trust, Manchester, United Kingdom. arenehan@picr.man.ac.uk
Citation:
Incident cancer burden attributable to excess body mass index in 30 European countries. 2010, 126 (3):692-702 Int. J. Cancer
Journal:
International Journal of Cancer
Issue Date:
1-Feb-2010
URI:
http://hdl.handle.net/10541/92837
DOI:
10.1002/ijc.24803
PubMed ID:
19645011
Type:
Article
Language:
en
ISSN:
1097-0215
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorRenehan, Andrew Gen
dc.contributor.authorSoerjomataram, Isabelleen
dc.contributor.authorTyson, Margareten
dc.contributor.authorEgger, Matthiasen
dc.contributor.authorZwahlen, Marcelen
dc.contributor.authorCoebergh, Jan-Willemen
dc.contributor.authorBuchan, Iainen
dc.date.accessioned2010-02-24T10:35:11Z-
dc.date.available2010-02-24T10:35:11Z-
dc.date.issued2010-02-01-
dc.identifier.citationIncident cancer burden attributable to excess body mass index in 30 European countries. 2010, 126 (3):692-702 Int. J. Canceren
dc.identifier.issn1097-0215-
dc.identifier.pmid19645011-
dc.identifier.doi10.1002/ijc.24803-
dc.identifier.urihttp://hdl.handle.net/10541/92837-
dc.description.abstractExcess adiposity is associated with increased risks of developing adult malignancies. To inform public health policy and guide further research, the incident cancer burden attributable to excess body mass index (BMI >or= 25 kg/m(2)) across 30 European countries were estimated. Population attributable risks (PARs) were calculated using European- and gender-specific risk estimates from a published meta-analysis and gender-specific mean BMI estimates from a World Health Organization Global Infobase. Country-specific numbers of new cancers were derived from Globocan2002. A ten-year lag-period between risk exposure and cancer incidence was assumed and 95% confidence intervals (CI) were estimated in Monte Carlo simulations. In 2002, there were 2,171,351 new all cancer diagnoses in the 30 countries of Europe. Estimated PARs were 2.5% (95% CI 1.5-3.6%) in men and 4.1% (2.3-5.9%) in women. These collectively corresponded to 70,288 (95% CI 40,069-100,668) new cases. Sensitivity analyses revealed estimates were most influenced by the assumed shape of the BMI distribution in the population and cancer-specific risk estimates. In a scenario analysis of a plausible contemporary (2008) population, the estimated PARs increased to 3.2% (2.1-4.3%) and 8.6% (5.6-11.5%), respectively, in men and women. Endometrial, post-menopausal breast and colorectal cancers accounted for 65% of these cancers. This analysis quantifies the burden of incident cancers attributable to excess BMI in Europe. The estimates reported here provide a baseline for future modelling, and underline the need for research into interventions to control weight in the context of endometrial, breast and colorectal cancer.en
dc.language.isoenen
dc.subjectCanceren
dc.subject.meshAdult-
dc.subject.meshBody Mass Index-
dc.subject.meshCausality-
dc.subject.meshComorbidity-
dc.subject.meshEurope-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshIncidence-
dc.subject.meshMale-
dc.subject.meshMeta-Analysis as Topic-
dc.subject.meshMonte Carlo Method-
dc.subject.meshNeoplasms-
dc.subject.meshObesity-
dc.subject.meshOverweight-
dc.subject.meshRisk-
dc.titleIncident cancer burden attributable to excess body mass index in 30 European countries.en
dc.typeArticleen
dc.contributor.departmentDepartment of Surgery, School of Cancer, Enabling Sciences and Technology, University of Manchester, Manchester Academic Health Science Centre, The Christie NHS Foundation Trust, Manchester, United Kingdom. arenehan@picr.man.ac.uken
dc.identifier.journalInternational Journal of Canceren

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