2.50
Hdl Handle:
http://hdl.handle.net/10541/92757
Title:
Id helix-loop-helix proteins in cell growth and differentiation.
Authors:
Norton, John D; Deed, Richard W; Craggs, Graham; Sablitzky, F
Abstract:
Id helix-loop-helix proteins function at a general level as positive regulators of cell growth and as negative regulators of cell differentiation. They act as dominant-negative antagonists of other helix-loop-helix transcription factors, which drive cell lineage commitment and differentiation in diverse cell types of higher eukaryotes. In addition, the functions of Id proteins are integrated with cell-cycle-regulatory pathways orchestrated by cyclin-dependent kinases and the retinoblastoma protein. Here, some of the recent advances that highlight the importance of Id proteins as regulatory intermediates for coordinating differentiation-linked gene expression with cell-cycle control in response to extracellular signalling are reviewed.
Affiliation:
Cancer Research Campaign Dept of Gene Regulation, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, UK. JNorton@picr.man.ac.uk
Citation:
Id helix-loop-helix proteins in cell growth and differentiation. 1998, 8 (2):58-65 Trends Cell Biol.
Journal:
Trends in Cell Biology
Issue Date:
Feb-1998
URI:
http://hdl.handle.net/10541/92757
PubMed ID:
9695810
Type:
Article
Language:
en
ISSN:
0962-8924
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorNorton, John Den
dc.contributor.authorDeed, Richard Wen
dc.contributor.authorCraggs, Grahamen
dc.contributor.authorSablitzky, Fen
dc.date.accessioned2010-02-23T13:19:46Z-
dc.date.available2010-02-23T13:19:46Z-
dc.date.issued1998-02-
dc.identifier.citationId helix-loop-helix proteins in cell growth and differentiation. 1998, 8 (2):58-65 Trends Cell Biol.en
dc.identifier.issn0962-8924-
dc.identifier.pmid9695810-
dc.identifier.urihttp://hdl.handle.net/10541/92757-
dc.description.abstractId helix-loop-helix proteins function at a general level as positive regulators of cell growth and as negative regulators of cell differentiation. They act as dominant-negative antagonists of other helix-loop-helix transcription factors, which drive cell lineage commitment and differentiation in diverse cell types of higher eukaryotes. In addition, the functions of Id proteins are integrated with cell-cycle-regulatory pathways orchestrated by cyclin-dependent kinases and the retinoblastoma protein. Here, some of the recent advances that highlight the importance of Id proteins as regulatory intermediates for coordinating differentiation-linked gene expression with cell-cycle control in response to extracellular signalling are reviewed.en
dc.language.isoenen
dc.subject.meshAnimals-
dc.subject.meshCell Differentiation-
dc.subject.meshCell Division-
dc.subject.meshEukaryotic Cells-
dc.subject.meshHelix-Loop-Helix Motifs-
dc.subject.meshInhibitor of Differentiation Protein 1-
dc.subject.meshMolecular Sequence Data-
dc.subject.meshRepressor Proteins-
dc.subject.meshSequence Homology, Amino Acid-
dc.subject.meshTranscription Factors-
dc.titleId helix-loop-helix proteins in cell growth and differentiation.en
dc.typeArticleen
dc.contributor.departmentCancer Research Campaign Dept of Gene Regulation, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, UK. JNorton@picr.man.ac.uken
dc.identifier.journalTrends in Cell Biologyen
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