Tanning in human skin types II and III offers modest photoprotection against erythema.

2.50
Hdl Handle:
http://hdl.handle.net/10541/92735
Title:
Tanning in human skin types II and III offers modest photoprotection against erythema.
Authors:
Sheehan, J M; Potten, Christopher S; Young, A R
Abstract:
We have investigated the photoprotective properties of tanning using erythema as an endpoint. Previously unexposed buttock skin sites of 16 young, healthy adults (8 skin type II, and 8 skin type III) were exposed daily (Mon-Fri) for 2 weeks to 0.5 and 0.75 minimal erythema doses (MED) of solar-simulated radiation (SSR). Erythema and melanin levels were assessed daily both visually and quantitatively using a reflectance device. One week after the last tanning treatment, MED reassessments were made on pretreated sites and on adjacent nontreated sites, including sites from which stratum corneum was removed by tape stripping. Compared to skin type II, similar daily SSR treatments produced less erythema and more evident tanning in skin types III. Independent of skin type, all volunteers showed an increased MED value when assessed on the 0.75 MED- and 0.5 MED-treated sites compared to the MED value assessed on adjacent untreated sites. We express any increase in MED as an induced protection factor (IPF), i.e. (MED post-tan/MED pre-tan). Our data show mean IPF of 1.4 and of 2.1 in the 0.5 and 0.75 MED-treated sites respectively, in skin types II. Similar values were obtained in skin types III with IPF of 1.5 and 2.3 for the 0.5 and 0.75 MED-treated sites, respectively. In all cases, removal of the stratum corneum lowered the IPF by about 20%. Our results show that SSR-induced melanogenesis, whether in skin type II or III, offers only moderate protection against erythema and suggest that SSR-induced stratum corneum thickening affords less photoprotection than tanning.
Affiliation:
Department of Photobiology, St John's Institute of Dermatology, St Thomas's Hospital, London, UK. j.sheehan@umds.ac.uk
Citation:
Tanning in human skin types II and III offers modest photoprotection against erythema. 1998, 68 (4):588-92 Photochem. Photobiol.
Journal:
Photochemistry and Photobiology
Issue Date:
Oct-1998
URI:
http://hdl.handle.net/10541/92735
PubMed ID:
9796443
Type:
Article
Language:
en
ISSN:
0031-8655
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorSheehan, J Men
dc.contributor.authorPotten, Christopher Sen
dc.contributor.authorYoung, A Ren
dc.date.accessioned2010-02-23T11:09:15Z-
dc.date.available2010-02-23T11:09:15Z-
dc.date.issued1998-10-
dc.identifier.citationTanning in human skin types II and III offers modest photoprotection against erythema. 1998, 68 (4):588-92 Photochem. Photobiol.en
dc.identifier.issn0031-8655-
dc.identifier.pmid9796443-
dc.identifier.urihttp://hdl.handle.net/10541/92735-
dc.description.abstractWe have investigated the photoprotective properties of tanning using erythema as an endpoint. Previously unexposed buttock skin sites of 16 young, healthy adults (8 skin type II, and 8 skin type III) were exposed daily (Mon-Fri) for 2 weeks to 0.5 and 0.75 minimal erythema doses (MED) of solar-simulated radiation (SSR). Erythema and melanin levels were assessed daily both visually and quantitatively using a reflectance device. One week after the last tanning treatment, MED reassessments were made on pretreated sites and on adjacent nontreated sites, including sites from which stratum corneum was removed by tape stripping. Compared to skin type II, similar daily SSR treatments produced less erythema and more evident tanning in skin types III. Independent of skin type, all volunteers showed an increased MED value when assessed on the 0.75 MED- and 0.5 MED-treated sites compared to the MED value assessed on adjacent untreated sites. We express any increase in MED as an induced protection factor (IPF), i.e. (MED post-tan/MED pre-tan). Our data show mean IPF of 1.4 and of 2.1 in the 0.5 and 0.75 MED-treated sites respectively, in skin types II. Similar values were obtained in skin types III with IPF of 1.5 and 2.3 for the 0.5 and 0.75 MED-treated sites, respectively. In all cases, removal of the stratum corneum lowered the IPF by about 20%. Our results show that SSR-induced melanogenesis, whether in skin type II or III, offers only moderate protection against erythema and suggest that SSR-induced stratum corneum thickening affords less photoprotection than tanning.en
dc.language.isoenen
dc.subject.meshAdult-
dc.subject.meshDose-Response Relationship, Radiation-
dc.subject.meshErythema-
dc.subject.meshHumans-
dc.subject.meshSkin-
dc.subject.meshSunlight-
dc.subject.meshTime Factors-
dc.subject.meshUltraviolet Rays-
dc.titleTanning in human skin types II and III offers modest photoprotection against erythema.en
dc.typeArticleen
dc.contributor.departmentDepartment of Photobiology, St John's Institute of Dermatology, St Thomas's Hospital, London, UK. j.sheehan@umds.ac.uken
dc.identifier.journalPhotochemistry and Photobiologyen

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