2.50
Hdl Handle:
http://hdl.handle.net/10541/92733
Title:
5T4 oncofetal antigen in gastric carcinoma and its clinical significance.
Authors:
Starzynska, T; Wiechowska-Kozlowska, A; Marlicz, K; Bromley, Michael; Roberts, Stephen A; Lawniczak, M; Kolodziej, B; Zyluk, A; Stern, Peter L
Abstract:
OBJECTIVE: To evaluate the role of 5T4 antigen in gastric cancer progression and prognosis. DESIGN: A prospective study of 5T4 antigen expression in primary, secondary and recurrent gastric carcinoma, the relationship to selected prognostic parameters and the course of disease. PATIENTS: Eighty six patients operated on for gastric cancer. TISSUE: One hundred and twenty two gastric tumours were studied, including 86 primary carcinomas, 32 coexisting lymph node metastases and four recurrent carcinomas. METHODS: Immunohistochemistry using 5T4 monoclonal antibody on frozen sections. RESULTS: The 5T4 antigen was detected in 41% of primary gastric tumours including early gastric cancer. A strong relationship was found between 5T4 positivity and tumour histology. Thus, 52% of gastric carcinomas of intestinal type expressed 5T4 antigen compared with 28% of the diffuse type (P = 0.028). Among 16 sets of primary gastric carcinomas and regional lymph node metastases, coordinate 5T4 expression was seen in 14 cases; the other two showed acquisition of positivity on metastatic tumour cells (carcinomas of diffuse type). 5T4 antigen was detected more frequently in carcinomas with p53 accumulation compared with those with undetectable p53 levels (P = 0.015). The presence of 5T4 in cancer cells was correlated with poor short-term prognosis (24% vs 49% of 2 year survival for 5T4 positive and negative tumours respectively, P = 0.024). The effect on survival was evident in the p53 negative group, with patients 5T4 positive showing worse survival (28% vs 60% in 2 years). CONCLUSIONS: Our results suggest that the assessment of 5T4 expression in gastric carcinoma can be helpful in identifying patients with poor short-term prognosis.
Affiliation:
Department of Gastroenterology, Medical Pomeranian Academy, Szczecin, Poland.
Citation:
5T4 oncofetal antigen in gastric carcinoma and its clinical significance. 1998, 10 (6):479-84 Eur J Gastroenterol Hepatol
Journal:
European Journal of Gastroenterology & Hepatology
Issue Date:
Jun-1998
URI:
http://hdl.handle.net/10541/92733
PubMed ID:
9855063
Type:
Article
Language:
en
ISSN:
0954-691X
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorStarzynska, Ten
dc.contributor.authorWiechowska-Kozlowska, Aen
dc.contributor.authorMarlicz, Ken
dc.contributor.authorBromley, Michaelen
dc.contributor.authorRoberts, Stephen Aen
dc.contributor.authorLawniczak, Men
dc.contributor.authorKolodziej, Ben
dc.contributor.authorZyluk, Aen
dc.contributor.authorStern, Peter Len
dc.date.accessioned2010-02-23T11:04:18Z-
dc.date.available2010-02-23T11:04:18Z-
dc.date.issued1998-06-
dc.identifier.citation5T4 oncofetal antigen in gastric carcinoma and its clinical significance. 1998, 10 (6):479-84 Eur J Gastroenterol Hepatolen
dc.identifier.issn0954-691X-
dc.identifier.pmid9855063-
dc.identifier.urihttp://hdl.handle.net/10541/92733-
dc.description.abstractOBJECTIVE: To evaluate the role of 5T4 antigen in gastric cancer progression and prognosis. DESIGN: A prospective study of 5T4 antigen expression in primary, secondary and recurrent gastric carcinoma, the relationship to selected prognostic parameters and the course of disease. PATIENTS: Eighty six patients operated on for gastric cancer. TISSUE: One hundred and twenty two gastric tumours were studied, including 86 primary carcinomas, 32 coexisting lymph node metastases and four recurrent carcinomas. METHODS: Immunohistochemistry using 5T4 monoclonal antibody on frozen sections. RESULTS: The 5T4 antigen was detected in 41% of primary gastric tumours including early gastric cancer. A strong relationship was found between 5T4 positivity and tumour histology. Thus, 52% of gastric carcinomas of intestinal type expressed 5T4 antigen compared with 28% of the diffuse type (P = 0.028). Among 16 sets of primary gastric carcinomas and regional lymph node metastases, coordinate 5T4 expression was seen in 14 cases; the other two showed acquisition of positivity on metastatic tumour cells (carcinomas of diffuse type). 5T4 antigen was detected more frequently in carcinomas with p53 accumulation compared with those with undetectable p53 levels (P = 0.015). The presence of 5T4 in cancer cells was correlated with poor short-term prognosis (24% vs 49% of 2 year survival for 5T4 positive and negative tumours respectively, P = 0.024). The effect on survival was evident in the p53 negative group, with patients 5T4 positive showing worse survival (28% vs 60% in 2 years). CONCLUSIONS: Our results suggest that the assessment of 5T4 expression in gastric carcinoma can be helpful in identifying patients with poor short-term prognosis.en
dc.language.isoenen
dc.subjectCancer Antigensen
dc.subjectCancer Recurrenceen
dc.subjectCancer Stagingen
dc.subjectStomach Canceren
dc.subjectBiological Tumour Markersen
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshAged, 80 and over-
dc.subject.meshAntigens, Neoplasm-
dc.subject.meshDisease Progression-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshImmunoenzyme Techniques-
dc.subject.meshLymphatic Metastasis-
dc.subject.meshMale-
dc.subject.meshMembrane Glycoproteins-
dc.subject.meshMiddle Aged-
dc.subject.meshNeoplasm Recurrence, Local-
dc.subject.meshNeoplasm Staging-
dc.subject.meshPredictive Value of Tests-
dc.subject.meshPrognosis-
dc.subject.meshProspective Studies-
dc.subject.meshStomach Neoplasms-
dc.subject.meshSurvival Analysis-
dc.subject.meshTumor Markers, Biological-
dc.title5T4 oncofetal antigen in gastric carcinoma and its clinical significance.en
dc.typeArticleen
dc.contributor.departmentDepartment of Gastroenterology, Medical Pomeranian Academy, Szczecin, Poland.en
dc.identifier.journalEuropean Journal of Gastroenterology & Hepatologyen

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