High tumor angiogenesis is associated with poorer survival in carcinoma of the cervix treated with radiotherapy.

2.50
Hdl Handle:
http://hdl.handle.net/10541/92041
Title:
High tumor angiogenesis is associated with poorer survival in carcinoma of the cervix treated with radiotherapy.
Authors:
Cooper, Rachel A; Wilks, Deepti P; Logue, John P; Davidson, Susan E; Hunter, Robin D; Roberts, Stephen A; West, Catharine M L
Abstract:
The purpose of this study was to examine the relationship between tumor angiogenesis and prognosis in carcinoma of the cervix treated with radiotherapy with a median follow-up time of 55 months. A retrospective study was carried out on 111 patients. Formalin-fixed, paraffin-embedded tumor biopsies were stained with anti-factor VIII using immunohistochemistry. Tumor angiogenesis was assessed by scoring the distance to the closest microvessel from random points within the tumor and the intratumor microvessel density (IMD) in the areas of highest neovascularization. High vascularity, as measured by both methods, was associated with a poor prognosis but was only significant for IMD. The 5-year survival rates for tumors with high versus low values were 50 and 65%, respectively. IMD was a significant prognostic factor within a Cox multivariate analysis. Higher tumor vascularity was associated with lower overall survival and locoregional control, but this association was not significant in the case of metastasis-free survival. The method used to assess tumor vascularity is important. The level of angiogenesis in carcinoma of the cervix is an independent prognostic parameter.
Affiliation:
Cancer Research Campaign Section of Genome Damage and Repair, Paterson Institute for Cancer Research, Manchester, United Kingdom.
Citation:
High tumor angiogenesis is associated with poorer survival in carcinoma of the cervix treated with radiotherapy. 1998, 4 (11):2795-800 Clin. Cancer Res.
Journal:
Clinical Cancer Research
Issue Date:
Nov-1998
URI:
http://hdl.handle.net/10541/92041
PubMed ID:
9829744
Type:
Article
Language:
en
ISSN:
1078-0432
Appears in Collections:
All Christie Publications ; All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorCooper, Rachel Aen
dc.contributor.authorWilks, Deepti Pen
dc.contributor.authorLogue, John Pen
dc.contributor.authorDavidson, Susan Een
dc.contributor.authorHunter, Robin Den
dc.contributor.authorRoberts, Stephen Aen
dc.contributor.authorWest, Catharine M Len
dc.date.accessioned2010-02-12T16:27:01Z-
dc.date.available2010-02-12T16:27:01Z-
dc.date.issued1998-11-
dc.identifier.citationHigh tumor angiogenesis is associated with poorer survival in carcinoma of the cervix treated with radiotherapy. 1998, 4 (11):2795-800 Clin. Cancer Res.en
dc.identifier.issn1078-0432-
dc.identifier.pmid9829744-
dc.identifier.urihttp://hdl.handle.net/10541/92041-
dc.description.abstractThe purpose of this study was to examine the relationship between tumor angiogenesis and prognosis in carcinoma of the cervix treated with radiotherapy with a median follow-up time of 55 months. A retrospective study was carried out on 111 patients. Formalin-fixed, paraffin-embedded tumor biopsies were stained with anti-factor VIII using immunohistochemistry. Tumor angiogenesis was assessed by scoring the distance to the closest microvessel from random points within the tumor and the intratumor microvessel density (IMD) in the areas of highest neovascularization. High vascularity, as measured by both methods, was associated with a poor prognosis but was only significant for IMD. The 5-year survival rates for tumors with high versus low values were 50 and 65%, respectively. IMD was a significant prognostic factor within a Cox multivariate analysis. Higher tumor vascularity was associated with lower overall survival and locoregional control, but this association was not significant in the case of metastasis-free survival. The method used to assess tumor vascularity is important. The level of angiogenesis in carcinoma of the cervix is an independent prognostic parameter.en
dc.language.isoenen
dc.subjectUterine Cervical Canceren
dc.subject.meshAdenocarcinoma-
dc.subject.meshAnalysis of Variance-
dc.subject.meshCarcinoma, Squamous Cell-
dc.subject.meshFemale-
dc.subject.meshFollow-Up Studies-
dc.subject.meshHumans-
dc.subject.meshMultivariate Analysis-
dc.subject.meshNeovascularization, Pathologic-
dc.subject.meshOutcome Assessment (Health Care)-
dc.subject.meshPrognosis-
dc.subject.meshReproducibility of Results-
dc.subject.meshSurvival Analysis-
dc.subject.meshUterine Cervical Neoplasms-
dc.titleHigh tumor angiogenesis is associated with poorer survival in carcinoma of the cervix treated with radiotherapy.en
dc.typeArticleen
dc.contributor.departmentCancer Research Campaign Section of Genome Damage and Repair, Paterson Institute for Cancer Research, Manchester, United Kingdom.en
dc.identifier.journalClinical Cancer Researchen

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