Epithelial proliferation and hormone receptor status in the normal post-menopausal breast and the effects of hormone replacement therapy.

2.50
Hdl Handle:
http://hdl.handle.net/10541/92036
Title:
Epithelial proliferation and hormone receptor status in the normal post-menopausal breast and the effects of hormone replacement therapy.
Authors:
Hargreaves, Danielle F; Knox, W Fiona; Swindell, Ric; Potten, Christopher S; Bundred, Nigel J
Abstract:
The proliferation rate (as assessed by Ki67 expression) and expression of oestrogen-regulated progesterone receptor (PR) was studied in normal post-menopausal breast epithelium. Normal breast epithelium from patients receiving hormone replacement therapy (HRT) at the time of surgery containing either oestrogen alone (E2) or oestrogen and progesterone combined activities (E2 + P) was also studied, as HRT has been linked to an increased breast cancer risk. Samples of breast tissue, containing normal epithelium, from 185 patients undergoing surgery for benign or malignant disease were immunocytochemically stained for PR and Ki67. The percentage of labelled cells was expressed as the labelling index (LI). The median Ki67 LI in normal post-menopausal breast epithelium was 0.19 and median PR LI was 4.75, and both were unaffected by patient age, duration of menopause or if the tissue sample originated from a breast with benign or malignant disease. Proliferation did not alter significantly in patients taking HRT (P = 0.61); however, PR expression was up-regulated in both E2 and E2 + P users (P = 0.01). The dose and duration of HRT had no effect on either parameter. A possible attenuation of sensitivity to oestradiol-induced proliferation but not to PR expression occurs in the post-menopausal breast.
Affiliation:
Department of Epithelial Biology, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, UK.
Citation:
Epithelial proliferation and hormone receptor status in the normal post-menopausal breast and the effects of hormone replacement therapy. 1998, 78 (7):945-9 Br. J. Cancer
Journal:
British Journal of Cancer
Issue Date:
Oct-1998
URI:
http://hdl.handle.net/10541/92036
PubMed ID:
9764588
Type:
Article
Language:
en
ISSN:
0007-0920
Appears in Collections:
All Christie Publications ; All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorHargreaves, Danielle Fen
dc.contributor.authorKnox, W Fionaen
dc.contributor.authorSwindell, Ricen
dc.contributor.authorPotten, Christopher Sen
dc.contributor.authorBundred, Nigel Jen
dc.date.accessioned2010-02-12T16:13:41Z-
dc.date.available2010-02-12T16:13:41Z-
dc.date.issued1998-10-
dc.identifier.citationEpithelial proliferation and hormone receptor status in the normal post-menopausal breast and the effects of hormone replacement therapy. 1998, 78 (7):945-9 Br. J. Canceren
dc.identifier.issn0007-0920-
dc.identifier.pmid9764588-
dc.identifier.urihttp://hdl.handle.net/10541/92036-
dc.description.abstractThe proliferation rate (as assessed by Ki67 expression) and expression of oestrogen-regulated progesterone receptor (PR) was studied in normal post-menopausal breast epithelium. Normal breast epithelium from patients receiving hormone replacement therapy (HRT) at the time of surgery containing either oestrogen alone (E2) or oestrogen and progesterone combined activities (E2 + P) was also studied, as HRT has been linked to an increased breast cancer risk. Samples of breast tissue, containing normal epithelium, from 185 patients undergoing surgery for benign or malignant disease were immunocytochemically stained for PR and Ki67. The percentage of labelled cells was expressed as the labelling index (LI). The median Ki67 LI in normal post-menopausal breast epithelium was 0.19 and median PR LI was 4.75, and both were unaffected by patient age, duration of menopause or if the tissue sample originated from a breast with benign or malignant disease. Proliferation did not alter significantly in patients taking HRT (P = 0.61); however, PR expression was up-regulated in both E2 and E2 + P users (P = 0.01). The dose and duration of HRT had no effect on either parameter. A possible attenuation of sensitivity to oestradiol-induced proliferation but not to PR expression occurs in the post-menopausal breast.en
dc.language.isoenen
dc.subjectOestrogen Replacement Therapyen
dc.subject.meshAged-
dc.subject.meshBiological Markers-
dc.subject.meshBreast-
dc.subject.meshCell Division-
dc.subject.meshEpithelial Cells-
dc.subject.meshEstradiol-
dc.subject.meshEstrogen Replacement Therapy-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshKi-67 Antigen-
dc.subject.meshMiddle Aged-
dc.subject.meshPostmenopause-
dc.subject.meshProgesterone-
dc.subject.meshReceptors, Progesterone-
dc.subject.meshRetrospective Studies-
dc.titleEpithelial proliferation and hormone receptor status in the normal post-menopausal breast and the effects of hormone replacement therapy.en
dc.typeArticleen
dc.contributor.departmentDepartment of Epithelial Biology, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, UK.en
dc.identifier.journalBritish Journal of Canceren

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