Bryostatin 1-tamoxifen combinations show synergistic effects on the inhibition of growth of P388 cells in vitro.

2.50
Hdl Handle:
http://hdl.handle.net/10541/92029
Title:
Bryostatin 1-tamoxifen combinations show synergistic effects on the inhibition of growth of P388 cells in vitro.
Authors:
McGown, Alan T; Jayson, Gordon C ( 0000-0002-8515-8944 ) ; Pettit, G R; Haran, M S; Ward, Timothy H; Crowther, Derek
Abstract:
This study shows that combinations of bryostatin 1, a novel modulator of protein kinase C currently under clinical evaluation, with the anti-oestrogenic agent tamoxifen caused a large synergistic enhancement of growth inhibition in P388 cells in vitro. The growth-inhibitory effects of bryostatin 1 in the presence of non-inhibitory concentrations of tamoxifen were increased by approximately 200-fold, whereas growth inhibition by tamoxifen in the presence of non-inhibitory concentrations of bryostatin 1 were increased over 30-fold. These data have been confirmed by isobologram analysis. The precise mechanism underlying this effect is unknown, although preliminary data implicating protein kinase C is presented. The magnitude of this synergistic effect, together with evidence of clinical responses seen when these agents were given sequentially in ovarian cancer, merits further study.
Affiliation:
Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, UK.
Citation:
Bryostatin 1-tamoxifen combinations show synergistic effects on the inhibition of growth of P388 cells in vitro. 1998, 77 (2):216-20 Br. J. Cancer
Journal:
British Journal of Cancer
Issue Date:
1998
URI:
http://hdl.handle.net/10541/92029
PubMed ID:
9460991
Type:
Article
Language:
en
ISSN:
0007-0920
Appears in Collections:
All Christie Publications ; All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorMcGown, Alan Ten
dc.contributor.authorJayson, Gordon Cen
dc.contributor.authorPettit, G Ren
dc.contributor.authorHaran, M Sen
dc.contributor.authorWard, Timothy Hen
dc.contributor.authorCrowther, Dereken
dc.date.accessioned2010-02-12T15:51:41Z-
dc.date.available2010-02-12T15:51:41Z-
dc.date.issued1998-
dc.identifier.citationBryostatin 1-tamoxifen combinations show synergistic effects on the inhibition of growth of P388 cells in vitro. 1998, 77 (2):216-20 Br. J. Canceren
dc.identifier.issn0007-0920-
dc.identifier.pmid9460991-
dc.identifier.urihttp://hdl.handle.net/10541/92029-
dc.description.abstractThis study shows that combinations of bryostatin 1, a novel modulator of protein kinase C currently under clinical evaluation, with the anti-oestrogenic agent tamoxifen caused a large synergistic enhancement of growth inhibition in P388 cells in vitro. The growth-inhibitory effects of bryostatin 1 in the presence of non-inhibitory concentrations of tamoxifen were increased by approximately 200-fold, whereas growth inhibition by tamoxifen in the presence of non-inhibitory concentrations of bryostatin 1 were increased over 30-fold. These data have been confirmed by isobologram analysis. The precise mechanism underlying this effect is unknown, although preliminary data implicating protein kinase C is presented. The magnitude of this synergistic effect, together with evidence of clinical responses seen when these agents were given sequentially in ovarian cancer, merits further study.en
dc.language.isoenen
dc.subjectLeukaemia P388en
dc.subject.meshAnimals-
dc.subject.meshBryostatins-
dc.subject.meshCell Division-
dc.subject.meshDrug Synergism-
dc.subject.meshEnzyme Activation-
dc.subject.meshGrowth Inhibitors-
dc.subject.meshLactones-
dc.subject.meshLeukemia P388-
dc.subject.meshMacrolides-
dc.subject.meshMice-
dc.subject.meshProtein Kinase C-
dc.subject.meshStaurosporine-
dc.subject.meshTamoxifen-
dc.subject.meshTetradecanoylphorbol Acetate-
dc.titleBryostatin 1-tamoxifen combinations show synergistic effects on the inhibition of growth of P388 cells in vitro.en
dc.typeArticleen
dc.contributor.departmentPaterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, UK.en
dc.identifier.journalBritish Journal of Canceren

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