Loss of CD44 variant 6 expression differentiates small cell carcinoma of urinary bladder from urothelial (transitional cell) carcinoma.

2.50
Hdl Handle:
http://hdl.handle.net/10541/92017
Title:
Loss of CD44 variant 6 expression differentiates small cell carcinoma of urinary bladder from urothelial (transitional cell) carcinoma.
Authors:
Iczkowski, K A; Shanks, Jonathan H; Bostwick, D G
Abstract:
AIMS: Small cell carcinoma of the urinary bladder has a more aggressive biological potential than urothelial carcinoma, but its morphology may overlap with poorly differentiated urothelial carcinoma. The CD44 family of glycoproteins mediates cell-cell and cell-matrix adhesion. Aberrant regulation of expression of CD44, and particularly its v6 variant exon, has been correlated with aggressive or metastatic phenotype of some cancers. We measured the degree of protein expression of CD44v6 in small cell and urothelial bladder carcinoma. METHOD AND RESULTS: Immunohistochemical staining was performed with monoclonal antibodies against CD44v6. Immunoreactivity was absent in 25 of 27 cases of small cell carcinoma, with two showing only weak staining of fewer than 10% of cells. In contrast, all 12 cases of moderately or poorly differentiated urothelial carcinoma displayed moderately intense reactivity in 50% to 100% of cells. CONCLUSIONS: CD44v6 immunostaining discriminates cases of poorly differentiated urothelial carcinoma from small cell carcinoma. It also highlights the presence of mixed small cell urothelial differentiation when present.
Affiliation:
Department of Pathology, Mayo Clinic, Rochester, Minnesota, USA.
Citation:
Loss of CD44 variant 6 expression differentiates small cell carcinoma of urinary bladder from urothelial (transitional cell) carcinoma. 1998, 32 (4):322-7 Histopathology
Journal:
Histopathology
Issue Date:
Apr-1998
URI:
http://hdl.handle.net/10541/92017
DOI:
10.1046/j.1365-2559.1998.00398.x
PubMed ID:
9602328
Type:
Article
Language:
en
ISSN:
0309-0167
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorIczkowski, K Aen
dc.contributor.authorShanks, Jonathan Hen
dc.contributor.authorBostwick, D Gen
dc.date.accessioned2010-02-12T15:10:51Z-
dc.date.available2010-02-12T15:10:51Z-
dc.date.issued1998-04-
dc.identifier.citationLoss of CD44 variant 6 expression differentiates small cell carcinoma of urinary bladder from urothelial (transitional cell) carcinoma. 1998, 32 (4):322-7 Histopathologyen
dc.identifier.issn0309-0167-
dc.identifier.pmid9602328-
dc.identifier.doi10.1046/j.1365-2559.1998.00398.x-
dc.identifier.urihttp://hdl.handle.net/10541/92017-
dc.description.abstractAIMS: Small cell carcinoma of the urinary bladder has a more aggressive biological potential than urothelial carcinoma, but its morphology may overlap with poorly differentiated urothelial carcinoma. The CD44 family of glycoproteins mediates cell-cell and cell-matrix adhesion. Aberrant regulation of expression of CD44, and particularly its v6 variant exon, has been correlated with aggressive or metastatic phenotype of some cancers. We measured the degree of protein expression of CD44v6 in small cell and urothelial bladder carcinoma. METHOD AND RESULTS: Immunohistochemical staining was performed with monoclonal antibodies against CD44v6. Immunoreactivity was absent in 25 of 27 cases of small cell carcinoma, with two showing only weak staining of fewer than 10% of cells. In contrast, all 12 cases of moderately or poorly differentiated urothelial carcinoma displayed moderately intense reactivity in 50% to 100% of cells. CONCLUSIONS: CD44v6 immunostaining discriminates cases of poorly differentiated urothelial carcinoma from small cell carcinoma. It also highlights the presence of mixed small cell urothelial differentiation when present.en
dc.language.isoenen
dc.subjectUrinary Bladder Canceren
dc.subject.meshAged-
dc.subject.meshAntigens, CD44-
dc.subject.meshCarcinoma, Small Cell-
dc.subject.meshCarcinoma, Transitional Cell-
dc.subject.meshDiagnosis, Differential-
dc.subject.meshFemale-
dc.subject.meshGlycoproteins-
dc.subject.meshHumans-
dc.subject.meshImmunohistochemistry-
dc.subject.meshMale-
dc.subject.meshUrinary Bladder Neoplasms-
dc.subject.meshUrothelium-
dc.titleLoss of CD44 variant 6 expression differentiates small cell carcinoma of urinary bladder from urothelial (transitional cell) carcinoma.en
dc.typeArticleen
dc.contributor.departmentDepartment of Pathology, Mayo Clinic, Rochester, Minnesota, USA.en
dc.identifier.journalHistopathologyen
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