Relationships between different measurements of vascularity and clinico-pathological parameters in breast cancer.

2.50
Hdl Handle:
http://hdl.handle.net/10541/92010
Title:
Relationships between different measurements of vascularity and clinico-pathological parameters in breast cancer.
Authors:
Pendleton, N; Pazouki, S; Heerkens, E; Smither, Rachel L; Chisholm, D M; Moore, James V; Howell, Anthony ( 0000-0002-3879-5991 ) ; Horan, M A; Schor, Ana M
Abstract:
Microvascular density has been put forward as an independent prognostic factor in breast cancer, with high levels indicating poorer prognosis. However, various studies have failed to confirm its prognostic value. The reasons for the contradictory results are not known, but it is believed that methodological differences are responsible. To test this hypothesis, we have used four different methods of assessing vascularity (average and highest microvascular density, microvascular volume and image analysis of vascular area) and related them to known prognostic factors in 51 cases of breast cancer NOS. All four methods showed a significant correlation with each other, with the exception of image analysis vs microvascular volume. The average microvascular density was significantly lower in p53 positive compared to negative tumours (median 38.4 and 66.2; IQR 31.1 and 49.4, respectively, p < 0.05). Vascularity, measured by the four methods, was not associated with nodal status or any other parameter examined.
Affiliation:
University Department of Geriatric Medicine, Hope Hospital, Salford, U.K.
Citation:
Relationships between different measurements of vascularity and clinico-pathological parameters in breast cancer., 18 (6B):4565-8 Anticancer Res.
Journal:
Anticancer Research
Issue Date:
1998
URI:
http://hdl.handle.net/10541/92010
PubMed ID:
9891519
Type:
Article
Language:
en
ISSN:
0250-7005
Appears in Collections:
All Christie Publications ; All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorPendleton, Nen
dc.contributor.authorPazouki, Sen
dc.contributor.authorHeerkens, Een
dc.contributor.authorSmither, Rachel Len
dc.contributor.authorChisholm, D Men
dc.contributor.authorMoore, James Ven
dc.contributor.authorHowell, Anthonyen
dc.contributor.authorHoran, M Aen
dc.contributor.authorSchor, Ana Men
dc.date.accessioned2010-02-12T15:57:18Z-
dc.date.available2010-02-12T15:57:18Z-
dc.date.issued1998-
dc.identifier.citationRelationships between different measurements of vascularity and clinico-pathological parameters in breast cancer., 18 (6B):4565-8 Anticancer Res.en
dc.identifier.issn0250-7005-
dc.identifier.pmid9891519-
dc.identifier.urihttp://hdl.handle.net/10541/92010-
dc.description.abstractMicrovascular density has been put forward as an independent prognostic factor in breast cancer, with high levels indicating poorer prognosis. However, various studies have failed to confirm its prognostic value. The reasons for the contradictory results are not known, but it is believed that methodological differences are responsible. To test this hypothesis, we have used four different methods of assessing vascularity (average and highest microvascular density, microvascular volume and image analysis of vascular area) and related them to known prognostic factors in 51 cases of breast cancer NOS. All four methods showed a significant correlation with each other, with the exception of image analysis vs microvascular volume. The average microvascular density was significantly lower in p53 positive compared to negative tumours (median 38.4 and 66.2; IQR 31.1 and 49.4, respectively, p < 0.05). Vascularity, measured by the four methods, was not associated with nodal status or any other parameter examined.en
dc.language.isoenen
dc.subjectBreast Canceren
dc.subjectCancer Invasivenessen
dc.subjectCancer Stagingen
dc.subjectOestrogen Receptorsen
dc.subjectTumour Suppressor Protein p53en
dc.subject.meshAged-
dc.subject.meshBreast Neoplasms-
dc.subject.meshCarcinoma, Intraductal, Noninfiltrating-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshImage Processing, Computer-Assisted-
dc.subject.meshLymphatic Metastasis-
dc.subject.meshMicrocirculation-
dc.subject.meshMicroscopy, Fluorescence-
dc.subject.meshMiddle Aged-
dc.subject.meshNeoplasm Invasiveness-
dc.subject.meshNeoplasm Staging-
dc.subject.meshPrognosis-
dc.subject.meshReceptor, erbB-2-
dc.subject.meshReceptors, Estrogen-
dc.subject.meshReceptors, Progesterone-
dc.subject.meshTumor Suppressor Protein p53-
dc.titleRelationships between different measurements of vascularity and clinico-pathological parameters in breast cancer.en
dc.typeArticleen
dc.contributor.departmentUniversity Department of Geriatric Medicine, Hope Hospital, Salford, U.K.en
dc.identifier.journalAnticancer Researchen

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