Predictive value of clinical examination, transrectal ultrasound and magnetic resonance imaging prior to radiotherapy in carcinoma of the cervix.

2.50
Hdl Handle:
http://hdl.handle.net/10541/91995
Title:
Predictive value of clinical examination, transrectal ultrasound and magnetic resonance imaging prior to radiotherapy in carcinoma of the cervix.
Authors:
Hawnaur, J M; Johnson, Richard J; Carrington, Bernadette M; Hunter, Robin D
Abstract:
The objectives of this study were to compare tumour staging and volume assessment by examination under anaesthesia (EUA), transrectal ultrasound (TRU) and magnetic resonance imaging (MRI) in patients with invasive carcinoma of the cervix, and to correlate findings with long-term outcome following treatment by radiotherapy. Tumour staging was performed on 60 patients immediately before starting radiotherapy. Clinicians and radiologists performing EUA, TRU or MRI were blinded to the results of other investigations. Tumour stage and dimensions were recorded prospectively for each technique, and analysed for concordance. The relationship between pre-treatment stage, size of tumour and patient outcome after radiotherapy was assessed, using clinical status 5 years after treatment as the truth measure. EUA, TRU and MRI assigned the same tumour stage in only 30% of patients and EUA and MRI agreed tumour stage in a further 27%. In cases of disagreement, the MRI stage correlated better with outcome than the TRU or EUA stage. There was a significant difference between tumour volume obtained from measurements made on MRI and those from TRU. 62% of patients with enlarged lymph nodes on pre-treatment MRI either died, or developed tumour recurrence or metastases. The ability of MRI to assess the full extent of bulky tumours and the presence of lymph node enlargement was an advantage over both EUA and TRU in identifying patients with a poor prognosis.
Affiliation:
Department of Diagnostic Radiology, Victoria University of Manchester Medical School, UK.
Citation:
Predictive value of clinical examination, transrectal ultrasound and magnetic resonance imaging prior to radiotherapy in carcinoma of the cervix. 1998, 71 (848):819-27 Br J Radiol
Journal:
British Journal of Radiology
Issue Date:
Aug-1998
URI:
http://hdl.handle.net/10541/91995
PubMed ID:
9828793
Type:
Article
Language:
en
ISSN:
0007-1285
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorHawnaur, J Men
dc.contributor.authorJohnson, Richard Jen
dc.contributor.authorCarrington, Bernadette Men
dc.contributor.authorHunter, Robin Den
dc.date.accessioned2010-02-12T12:31:37Z-
dc.date.available2010-02-12T12:31:37Z-
dc.date.issued1998-08-
dc.identifier.citationPredictive value of clinical examination, transrectal ultrasound and magnetic resonance imaging prior to radiotherapy in carcinoma of the cervix. 1998, 71 (848):819-27 Br J Radiolen
dc.identifier.issn0007-1285-
dc.identifier.pmid9828793-
dc.identifier.urihttp://hdl.handle.net/10541/91995-
dc.description.abstractThe objectives of this study were to compare tumour staging and volume assessment by examination under anaesthesia (EUA), transrectal ultrasound (TRU) and magnetic resonance imaging (MRI) in patients with invasive carcinoma of the cervix, and to correlate findings with long-term outcome following treatment by radiotherapy. Tumour staging was performed on 60 patients immediately before starting radiotherapy. Clinicians and radiologists performing EUA, TRU or MRI were blinded to the results of other investigations. Tumour stage and dimensions were recorded prospectively for each technique, and analysed for concordance. The relationship between pre-treatment stage, size of tumour and patient outcome after radiotherapy was assessed, using clinical status 5 years after treatment as the truth measure. EUA, TRU and MRI assigned the same tumour stage in only 30% of patients and EUA and MRI agreed tumour stage in a further 27%. In cases of disagreement, the MRI stage correlated better with outcome than the TRU or EUA stage. There was a significant difference between tumour volume obtained from measurements made on MRI and those from TRU. 62% of patients with enlarged lymph nodes on pre-treatment MRI either died, or developed tumour recurrence or metastases. The ability of MRI to assess the full extent of bulky tumours and the presence of lymph node enlargement was an advantage over both EUA and TRU in identifying patients with a poor prognosis.en
dc.language.isoenen
dc.subjectCancer Invasivenessen
dc.subjectCancer Stagingen
dc.subjectUterine Cervical Canceren
dc.subject.meshFemale-
dc.subject.meshFollow-Up Studies-
dc.subject.meshHumans-
dc.subject.meshLymphatic Metastasis-
dc.subject.meshMagnetic Resonance Imaging-
dc.subject.meshNeoplasm Invasiveness-
dc.subject.meshNeoplasm Staging-
dc.subject.meshPrognosis-
dc.subject.meshProspective Studies-
dc.subject.meshSingle-Blind Method-
dc.subject.meshSurvival Rate-
dc.subject.meshTreatment Outcome-
dc.subject.meshUterine Cervical Neoplasms-
dc.titlePredictive value of clinical examination, transrectal ultrasound and magnetic resonance imaging prior to radiotherapy in carcinoma of the cervix.en
dc.typeArticleen
dc.contributor.departmentDepartment of Diagnostic Radiology, Victoria University of Manchester Medical School, UK.en
dc.identifier.journalBritish Journal of Radiologyen

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